Cell type atlas - GTPBP4 - The Human Protein Atlas

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GTPBP4

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	GTPBP4
Gene descriptionⁱ Full gene name according to HGNC.	GTP binding protein 4
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	54 NX
Lung	54 NX

Alveolar cells type 2	70 NX
Lung	69 NX

B-cells	33 NX
Colon	34 NX
Liver	32 NX
Kidney	31 NX

Basal glandular cells	58 NX
Prostate	58 NX

Basal keratinocytes	56 NX
Skin	56 NX

Bipolar cells	26 NX
Eye	25 NX

Cardiomyocytes	30 NX
Heart muscle	30 NX

Cholangiocytes	23 NX
Liver	23 NX

Ciliated cells	67 NX
Lung	67 NX

Club cells	108 NX
Lung	108 NX

Collecting duct cells	28 NX
Kidney	28 NX

Cone photoreceptor cells	18 NX
Eye	18 NX

Cytotrophoblasts	42 NX
Placenta	42 NX

Distal tubular cells	28 NX
Kidney	28 NX

Ductal cells	54 NX
Pancreas	54 NX

Early spermatids	49 NX
Testis	49 NX

Endothelial cells	31 NX
Lung	166 NX
Pancreas	79 NX
Prostate	59 NX
Placenta	38 NX
Liver	32 NX
Eye	31 NX
Testis	29 NX
Skin	23 NX
Heart muscle	16 NX

Enterocytes	10 NX
Colon	11 NX
Rectum	10 NX
Small intestine	10 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	38 NX
Pancreas	38 NX

Extravillous trophoblasts	46 NX
Placenta	46 NX

Fibroblasts	31 NX
Lung	170 NX
Prostate	68 NX
Placenta	34 NX
Skin	25 NX
Heart muscle	11 NX

Glandular cells	41 NX
Prostate	41 NX

Granulocytes	63 NX
Lung	107 NX
Colon	18 NX

Hepatocytes	24 NX
Liver	24 NX

Hofbauer cells	31 NX
Placenta	31 NX

Horizontal cells	22 NX
Eye	22 NX

Intestinal endocrine cells	21 NX
Colon	24 NX
Rectum	19 NX

Ito cells	21 NX
Liver	21 NX

Kupffer cells	26 NX
Liver	26 NX

Late spermatids	14 NX
Testis	14 NX

Leydig cells	23 NX
Testis	23 NX

Macrophages	29 NX
Lung	88 NX
Testis	32 NX
Prostate	30 NX
Kidney	29 NX
Skin	23 NX
Pancreas	23 NX

Melanocytes	22 NX
Skin	22 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	39 NX
Pancreas	39 NX

Mucus-secreting cells	25 NX
Colon	37 NX
Rectum	25 NX
Small intestine	17 NX

Muller glia cells	27 NX
Eye	27 NX

Pancreatic endocrine cells	52 NX
Pancreas	52 NX

Paneth cells	18 NX
Rectum	21 NX
Small intestine	18 NX
Colon	9 NX

Peritubular cells	28 NX
Testis	28 NX

Proximal tubular cells	24 NX
Kidney	24 NX

Rod photoreceptor cells	32 NX
Eye	32 NX

Sertoli cells	19 NX
Testis	19 NX

Smooth muscle cells	26 NX
Pancreas	95 NX
Prostate	47 NX
Heart muscle	26 NX
Skin	24 NX

Spermatocytes	87 NX
Testis	87 NX

Spermatogonia	85 NX
Testis	85 NX

Suprabasal keratinocytes	59 NX
Skin	59 NX

Syncytiotrophoblasts	80 NX
Placenta	80 NX

T-cells	25 NX
Lung	91 NX
Colon	43 NX
Kidney	27 NX
Skin	23 NX
Prostate	22 NX
Liver	20 NX

Undifferentiated cells	29 NX
Colon	40 NX
Small intestine	29 NX
Rectum	25 NX

Urothelial cells	77 NX
Prostate	77 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.