Cell type atlas - LIPA - The Human Protein Atlas

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LIPA

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	LIPA
Gene descriptionⁱ Full gene name according to HGNC.	Lipase A, lysosomal acid type
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (Kupffer cells, Hofbauer cells, Macrophages)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (intermediate monocyte, non-classical monocyte, classical monocyte, myeloid DC)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (AN3-CA, ASC TERT1)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Group enriched (Kupffer cells, Hofbauer cells, Macrophages)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	39 NX
Lung	39 NX

Alveolar cells type 2	42 NX
Lung	42 NX

B-cells	51 NX
Colon	52 NX
Kidney	49 NX
Liver	41 NX

Basal glandular cells	22 NX
Prostate	22 NX

Basal keratinocytes	16 NX
Skin	16 NX

Bipolar cells	5 NX
Eye	5 NX

Cardiomyocytes	9 NX
Heart muscle	9 NX

Cholangiocytes	46 NX
Liver	46 NX

Ciliated cells	15 NX
Lung	15 NX

Club cells	14 NX
Lung	14 NX

Collecting duct cells	31 NX
Kidney	31 NX

Cone photoreceptor cells	0 NX
Eye	0 NX

Cytotrophoblasts	28 NX
Placenta	28 NX

Distal tubular cells	18 NX
Kidney	18 NX

Ductal cells	30 NX
Pancreas	30 NX

Early spermatids	4 NX
Testis	4 NX

Endothelial cells	53 NX
Placenta	82 NX
Skin	68 NX
Eye	59 NX
Lung	55 NX
Heart muscle	50 NX
Testis	36 NX
Pancreas	32 NX
Prostate	31 NX
Liver	27 NX

Enterocytes	4 NX
Small intestine	136 NX
Colon	3 NX
Rectum	3 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	32 NX
Pancreas	32 NX

Extravillous trophoblasts	28 NX
Placenta	28 NX

Fibroblasts	35 NX
Skin	39 NX
Placenta	32 NX
Heart muscle	22 NX
Lung	16 NX
Prostate	13 NX

Glandular cells	15 NX
Prostate	15 NX

Granulocytes	28 NX
Lung	28 NX
Colon	28 NX

Hepatocytes	47 NX
Liver	47 NX

Hofbauer cells	503 NX
Placenta	503 NX

Horizontal cells	16 NX
Eye	16 NX

Intestinal endocrine cells	21 NX
Rectum	35 NX
Colon	7 NX

Ito cells	53 NX
Liver	53 NX

Kupffer cells	514 NX
Liver	514 NX

Late spermatids	2 NX
Testis	2 NX

Leydig cells	11 NX
Testis	11 NX

Macrophages	167 NX
Pancreas	461 NX
Prostate	401 NX
Kidney	260 NX
Lung	155 NX
Skin	84 NX
Testis	67 NX

Melanocytes	46 NX
Skin	46 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	28 NX
Pancreas	28 NX

Mucus-secreting cells	9 NX
Small intestine	10 NX
Rectum	9 NX
Colon	4 NX

Muller glia cells	29 NX
Eye	29 NX

Pancreatic endocrine cells	18 NX
Pancreas	18 NX

Paneth cells	6 NX
Small intestine	25 NX
Rectum	6 NX
Colon	3 NX

Peritubular cells	21 NX
Testis	21 NX

Proximal tubular cells	15 NX
Kidney	15 NX

Rod photoreceptor cells	1 NX
Eye	1 NX

Sertoli cells	7 NX
Testis	7 NX

Smooth muscle cells	22 NX
Skin	27 NX
Pancreas	22 NX
Prostate	16 NX
Heart muscle	7 NX

Spermatocytes	5 NX
Testis	5 NX

Spermatogonia	11 NX
Testis	11 NX

Suprabasal keratinocytes	11 NX
Skin	11 NX

Syncytiotrophoblasts	17 NX
Placenta	17 NX

T-cells	33 NX
Kidney	55 NX
Lung	39 NX
Prostate	35 NX
Skin	30 NX
Liver	23 NX
Colon	19 NX

Undifferentiated cells	9 NX
Small intestine	12 NX
Rectum	9 NX
Colon	5 NX

Urothelial cells	20 NX
Prostate	20 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.