Cell type atlas - POLD2 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

POLD2

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	POLD2
Gene descriptionⁱ Full gene name according to HGNC.	DNA polymerase delta 2, accessory subunit
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	9

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Late spermatids)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Late spermatids)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	6 NX
Lung	6 NX

Alveolar cells type 2	35 NX
Lung	35 NX

B-cells	22 NX
Liver	31 NX
Kidney	27 NX
Colon	18 NX

Basal glandular cells	62 NX
Prostate	62 NX

Basal keratinocytes	44 NX
Skin	44 NX

Bipolar cells	39 NX
Eye	39 NX

Cardiomyocytes	57 NX
Heart muscle	57 NX

Cholangiocytes	38 NX
Liver	38 NX

Ciliated cells	60 NX
Lung	60 NX

Club cells	38 NX
Lung	38 NX

Collecting duct cells	28 NX
Kidney	28 NX

Cone photoreceptor cells	30 NX
Eye	30 NX

Cytotrophoblasts	62 NX
Placenta	62 NX

Distal tubular cells	88 NX
Kidney	88 NX

Ductal cells	57 NX
Pancreas	57 NX

Early spermatids	89 NX
Testis	89 NX

Endothelial cells	29 NX
Placenta	57 NX
Pancreas	47 NX
Prostate	45 NX
Skin	39 NX
Lung	32 NX
Liver	27 NX
Testis	23 NX
Heart muscle	18 NX
Eye	17 NX

Enterocytes	12 NX
Colon	12 NX
Rectum	10 NX
Small intestine	10 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	52 NX
Pancreas	52 NX

Extravillous trophoblasts	70 NX
Placenta	70 NX

Fibroblasts	44 NX
Placenta	98 NX
Skin	43 NX
Prostate	40 NX
Heart muscle	31 NX
Lung	24 NX

Glandular cells	51 NX
Prostate	51 NX

Granulocytes	26 NX
Lung	33 NX
Colon	18 NX

Hepatocytes	85 NX
Liver	85 NX

Hofbauer cells	41 NX
Placenta	41 NX

Horizontal cells	51 NX
Eye	51 NX

Intestinal endocrine cells	40 NX
Colon	41 NX
Rectum	40 NX

Ito cells	20 NX
Liver	20 NX

Kupffer cells	12 NX
Liver	12 NX

Late spermatids	218 NX
Testis	218 NX

Leydig cells	39 NX
Testis	39 NX

Macrophages	16 NX
Skin	24 NX
Kidney	18 NX
Lung	15 NX
Testis	14 NX
Prostate	13 NX
Pancreas	12 NX

Melanocytes	47 NX
Skin	47 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	10 NX
Pancreas	10 NX

Mucus-secreting cells	53 NX
Rectum	53 NX
Colon	53 NX
Small intestine	37 NX

Muller glia cells	38 NX
Eye	38 NX

Pancreatic endocrine cells	40 NX
Pancreas	39 NX

Paneth cells	14 NX
Rectum	43 NX
Small intestine	14 NX
Colon	12 NX

Peritubular cells	50 NX
Testis	50 NX

Proximal tubular cells	79 NX
Kidney	79 NX

Rod photoreceptor cells	48 NX
Eye	48 NX

Sertoli cells	19 NX
Testis	19 NX

Smooth muscle cells	68 NX
Pancreas	93 NX
Prostate	68 NX
Skin	60 NX
Heart muscle	44 NX

Spermatocytes	59 NX
Testis	59 NX

Spermatogonia	65 NX
Testis	65 NX

Suprabasal keratinocytes	53 NX
Skin	53 NX

Syncytiotrophoblasts	30 NX
Placenta	30 NX

T-cells	23 NX
Lung	37 NX
Kidney	33 NX
Colon	25 NX
Skin	23 NX
Prostate	22 NX
Liver	20 NX

Undifferentiated cells	72 NX
Colon	111 NX
Small intestine	74 NX
Rectum	56 NX

Urothelial cells	63 NX
Prostate	63 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.