Cell type atlas - COA1 - The Human Protein Atlas

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COA1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	COA1
Gene descriptionⁱ Full gene name according to HGNC.	Cytochrome c oxidase assembly factor 1 homolog
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	27 NX
Lung	27 NX

Alveolar cells type 2	35 NX
Lung	35 NX

B-cells	59 NX
Liver	64 NX
Kidney	62 NX
Colon	48 NX

Basal glandular cells	59 NX
Prostate	59 NX

Basal keratinocytes	12 NX
Skin	12 NX

Bipolar cells	43 NX
Eye	43 NX

Cardiomyocytes	56 NX
Heart muscle	56 NX

Cholangiocytes	18 NX
Liver	18 NX

Ciliated cells	29 NX
Lung	29 NX

Club cells	24 NX
Lung	24 NX

Collecting duct cells	33 NX
Kidney	33 NX

Cone photoreceptor cells	43 NX
Eye	43 NX

Cytotrophoblasts	28 NX
Placenta	28 NX

Distal tubular cells	100 NX
Kidney	100 NX

Ductal cells	49 NX
Pancreas	49 NX

Early spermatids	5 NX
Testis	5 NX

Endothelial cells	26 NX
Pancreas	61 NX
Placenta	43 NX
Eye	37 NX
Testis	36 NX
Prostate	29 NX
Liver	25 NX
Lung	23 NX
Heart muscle	22 NX
Skin	21 NX

Enterocytes	17 NX
Small intestine	34 NX
Rectum	14 NX
Colon	10 NX

Erythroid cells	47 NX
Liver	47 NX

Exocrine glandular cells	37 NX
Pancreas	37 NX

Extravillous trophoblasts	43 NX
Placenta	43 NX

Fibroblasts	26 NX
Placenta	37 NX
Prostate	26 NX
Skin	21 NX
Lung	18 NX
Heart muscle	13 NX

Glandular cells	44 NX
Prostate	44 NX

Granulocytes	25 NX
Colon	28 NX
Lung	23 NX

Hepatocytes	19 NX
Liver	19 NX

Hofbauer cells	50 NX
Placenta	50 NX

Horizontal cells	32 NX
Eye	32 NX

Intestinal endocrine cells	27 NX
Rectum	33 NX
Colon	20 NX

Ito cells	18 NX
Liver	18 NX

Kupffer cells	34 NX
Liver	34 NX

Late spermatids	7 NX
Testis	7 NX

Leydig cells	27 NX
Testis	27 NX

Macrophages	35 NX
Kidney	44 NX
Pancreas	40 NX
Testis	40 NX
Prostate	38 NX
Lung	28 NX
Skin	19 NX

Melanocytes	35 NX
Skin	35 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	49 NX
Pancreas	49 NX

Mucus-secreting cells	21 NX
Rectum	22 NX
Colon	19 NX
Small intestine	18 NX

Muller glia cells	22 NX
Eye	22 NX

Pancreatic endocrine cells	39 NX
Pancreas	39 NX

Paneth cells	11 NX
Rectum	24 NX
Small intestine	11 NX
Colon	9 NX

Peritubular cells	18 NX
Testis	18 NX

Proximal tubular cells	100 NX
Kidney	100 NX

Rod photoreceptor cells	53 NX
Eye	53 NX

Sertoli cells	13 NX
Testis	13 NX

Smooth muscle cells	23 NX
Pancreas	60 NX
Prostate	24 NX
Skin	19 NX
Heart muscle	14 NX

Spermatocytes	54 NX
Testis	54 NX

Spermatogonia	85 NX
Testis	85 NX

Suprabasal keratinocytes	15 NX
Skin	15 NX

Syncytiotrophoblasts	15 NX
Placenta	15 NX

T-cells	52 NX
Colon	55 NX
Liver	55 NX
Kidney	54 NX
Lung	39 NX
Prostate	35 NX
Skin	20 NX

Undifferentiated cells	25 NX
Small intestine	28 NX
Rectum	23 NX
Colon	22 NX

Urothelial cells	38 NX
Prostate	38 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.