Cell type atlas - AHR - The Human Protein Atlas

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AHR

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	AHR
Gene descriptionⁱ Full gene name according to HGNC.	Aryl hydrocarbon receptor
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Transcription factors
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Alveolar cells type 1, granulocytes)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (hTCEpi, hTERT-HME1, RT4)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Alveolar cells type 1, granulocytes)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	140 NX
Lung	140 NX

Alveolar cells type 2	73 NX
Lung	73 NX

B-cells	9 NX
Colon	36 NX
Liver	9 NX
Kidney	0 NX

Basal glandular cells	40 NX
Prostate	40 NX

Basal keratinocytes	67 NX
Skin	67 NX

Bipolar cells	35 NX
Eye	35 NX

Cardiomyocytes	13 NX
Heart muscle	13 NX

Cholangiocytes	43 NX
Liver	43 NX

Ciliated cells	43 NX
Lung	43 NX

Club cells	75 NX
Lung	75 NX

Collecting duct cells	7 NX
Kidney	7 NX

Cone photoreceptor cells	8 NX
Eye	8 NX

Cytotrophoblasts	3 NX
Placenta	3 NX

Distal tubular cells	0 NX
Kidney	0 NX

Ductal cells	16 NX
Pancreas	16 NX

Early spermatids	5 NX
Testis	5 NX

Endothelial cells	55 NX
Skin	113 NX
Prostate	102 NX
Heart muscle	75 NX
Liver	56 NX
Testis	55 NX
Lung	55 NX
Placenta	37 NX
Eye	20 NX
Pancreas	18 NX

Enterocytes	14 NX
Colon	21 NX
Rectum	19 NX
Small intestine	9 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	13 NX
Pancreas	13 NX

Extravillous trophoblasts	1 NX
Placenta	1 NX

Fibroblasts	31 NX
Skin	133 NX
Prostate	61 NX
Heart muscle	55 NX
Lung	30 NX
Placenta	8 NX

Glandular cells	43 NX
Prostate	43 NX

Granulocytes	130 NX
Colon	147 NX
Lung	114 NX

Hepatocytes	40 NX
Liver	40 NX

Hofbauer cells	24 NX
Placenta	24 NX

Horizontal cells	41 NX
Eye	41 NX

Intestinal endocrine cells	5 NX
Rectum	7 NX
Colon	3 NX

Ito cells	44 NX
Liver	44 NX

Kupffer cells	75 NX
Liver	75 NX

Late spermatids	2 NX
Testis	2 NX

Leydig cells	3 NX
Testis	3 NX

Macrophages	73 NX
Skin	194 NX
Prostate	182 NX
Testis	75 NX
Lung	56 NX
Kidney	34 NX
Pancreas	16 NX

Melanocytes	67 NX
Skin	67 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	37 NX
Pancreas	37 NX

Mucus-secreting cells	11 NX
Colon	17 NX
Rectum	12 NX
Small intestine	7 NX

Muller glia cells	1 NX
Eye	1 NX

Pancreatic endocrine cells	25 NX
Pancreas	25 NX

Paneth cells	17 NX
Colon	26 NX
Rectum	17 NX
Small intestine	11 NX

Peritubular cells	3 NX
Testis	3 NX

Proximal tubular cells	6 NX
Kidney	6 NX

Rod photoreceptor cells	6 NX
Eye	6 NX

Sertoli cells	7 NX
Testis	7 NX

Smooth muscle cells	41 NX
Skin	116 NX
Prostate	41 NX
Heart muscle	23 NX
Pancreas	8 NX

Spermatocytes	2 NX
Testis	2 NX

Spermatogonia	2 NX
Testis	2 NX

Suprabasal keratinocytes	78 NX
Skin	78 NX

Syncytiotrophoblasts	18 NX
Placenta	18 NX

T-cells	8 NX
Skin	195 NX
Prostate	96 NX
Colon	84 NX
Lung	17 NX
Liver	7 NX
Kidney	5 NX

Undifferentiated cells	13 NX
Colon	24 NX
Rectum	13 NX
Small intestine	11 NX

Urothelial cells	90 NX
Prostate	90 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.