Cell type atlas - TMEM106B - The Human Protein Atlas

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TMEM106B

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TMEM106B
Gene descriptionⁱ Full gene name according to HGNC.	Transmembrane protein 106B
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Potential drug targets Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	69 NX
Lung	69 NX

Alveolar cells type 2	32 NX
Lung	32 NX

B-cells	22 NX
Colon	27 NX
Liver	21 NX
Kidney	18 NX

Basal glandular cells	35 NX
Prostate	35 NX

Basal keratinocytes	33 NX
Skin	33 NX

Bipolar cells	52 NX
Eye	52 NX

Cardiomyocytes	35 NX
Heart muscle	35 NX

Cholangiocytes	41 NX
Liver	41 NX

Ciliated cells	36 NX
Lung	36 NX

Club cells	27 NX
Lung	27 NX

Collecting duct cells	63 NX
Kidney	63 NX

Cone photoreceptor cells	43 NX
Eye	43 NX

Cytotrophoblasts	48 NX
Placenta	48 NX

Distal tubular cells	15 NX
Kidney	15 NX

Ductal cells	97 NX
Pancreas	97 NX

Early spermatids	3 NX
Testis	3 NX

Endothelial cells	30 NX
Skin	40 NX
Testis	39 NX
Liver	34 NX
Heart muscle	31 NX
Lung	26 NX
Placenta	25 NX
Prostate	24 NX
Eye	23 NX
Pancreas	4 NX

Enterocytes	46 NX
Rectum	55 NX
Small intestine	46 NX
Colon	45 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	51 NX
Pancreas	51 NX

Extravillous trophoblasts	30 NX
Placenta	30 NX

Fibroblasts	53 NX
Placenta	123 NX
Skin	51 NX
Prostate	37 NX
Lung	35 NX
Heart muscle	16 NX

Glandular cells	60 NX
Prostate	60 NX

Granulocytes	14 NX
Lung	19 NX
Colon	9 NX

Hepatocytes	61 NX
Liver	61 NX

Hofbauer cells	29 NX
Placenta	29 NX

Horizontal cells	62 NX
Eye	62 NX

Intestinal endocrine cells	55 NX
Rectum	56 NX
Colon	54 NX

Ito cells	37 NX
Liver	37 NX

Kupffer cells	27 NX
Liver	27 NX

Late spermatids	4 NX
Testis	4 NX

Leydig cells	46 NX
Testis	46 NX

Macrophages	21 NX
Lung	25 NX
Skin	25 NX
Kidney	24 NX
Prostate	20 NX
Pancreas	19 NX
Testis	14 NX

Melanocytes	35 NX
Skin	35 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	12 NX
Pancreas	12 NX

Mucus-secreting cells	41 NX
Rectum	41 NX
Small intestine	36 NX
Colon	26 NX

Muller glia cells	88 NX
Eye	88 NX

Pancreatic endocrine cells	61 NX
Pancreas	61 NX

Paneth cells	52 NX
Small intestine	60 NX
Rectum	52 NX
Colon	35 NX

Peritubular cells	57 NX
Testis	57 NX

Proximal tubular cells	53 NX
Kidney	53 NX

Rod photoreceptor cells	45 NX
Eye	45 NX

Sertoli cells	32 NX
Testis	32 NX

Smooth muscle cells	32 NX
Prostate	41 NX
Skin	34 NX
Heart muscle	32 NX
Pancreas	25 NX

Spermatocytes	42 NX
Testis	42 NX

Spermatogonia	28 NX
Testis	28 NX

Suprabasal keratinocytes	38 NX
Skin	38 NX

Syncytiotrophoblasts	113 NX
Placenta	113 NX

T-cells	30 NX
Kidney	46 NX
Skin	33 NX
Lung	33 NX
Colon	30 NX
Prostate	26 NX
Liver	24 NX

Undifferentiated cells	42 NX
Rectum	44 NX
Small intestine	36 NX
Colon	33 NX

Urothelial cells	40 NX
Prostate	40 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.