Cell type atlas - RPA3 - The Human Protein Atlas

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RPA3

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	RPA3
Gene descriptionⁱ Full gene name according to HGNC.	Replication protein A3
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Erythroid cells, Proximal tubular cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Erythroid cells, Proximal tubular cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	36 NX
Lung	36 NX

Alveolar cells type 2	43 NX
Lung	43 NX

B-cells	119 NX
Liver	140 NX
Kidney	125 NX
Colon	114 NX

Basal glandular cells	50 NX
Prostate	50 NX

Basal keratinocytes	36 NX
Skin	36 NX

Bipolar cells	22 NX
Eye	22 NX

Cardiomyocytes	35 NX
Heart muscle	35 NX

Cholangiocytes	61 NX
Liver	61 NX

Ciliated cells	155 NX
Lung	155 NX

Club cells	50 NX
Lung	50 NX

Collecting duct cells	68 NX
Kidney	68 NX

Cone photoreceptor cells	10 NX
Eye	10 NX

Cytotrophoblasts	107 NX
Placenta	107 NX

Distal tubular cells	232 NX
Kidney	232 NX

Ductal cells	76 NX
Pancreas	76 NX

Early spermatids	69 NX
Testis	69 NX

Endothelial cells	30 NX
Placenta	55 NX
Lung	38 NX
Pancreas	36 NX
Testis	35 NX
Heart muscle	32 NX
Skin	30 NX
Liver	25 NX
Eye	23 NX
Prostate	20 NX

Enterocytes	55 NX
Small intestine	64 NX
Rectum	53 NX
Colon	42 NX

Erythroid cells	491 NX
Liver	491 NX

Exocrine glandular cells	92 NX
Pancreas	92 NX

Extravillous trophoblasts	213 NX
Placenta	213 NX

Fibroblasts	34 NX
Placenta	87 NX
Lung	48 NX
Skin	31 NX
Heart muscle	23 NX
Prostate	13 NX

Glandular cells	34 NX
Prostate	34 NX

Granulocytes	53 NX
Colon	64 NX
Lung	42 NX

Hepatocytes	145 NX
Liver	145 NX

Hofbauer cells	112 NX
Placenta	112 NX

Horizontal cells	16 NX
Eye	16 NX

Intestinal endocrine cells	24 NX
Rectum	35 NX
Colon	14 NX

Ito cells	36 NX
Liver	36 NX

Kupffer cells	46 NX
Liver	46 NX

Late spermatids	15 NX
Testis	15 NX

Leydig cells	36 NX
Testis	36 NX

Macrophages	65 NX
Kidney	89 NX
Pancreas	87 NX
Prostate	68 NX
Skin	55 NX
Lung	54 NX
Testis	37 NX

Melanocytes	54 NX
Skin	54 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	79 NX
Pancreas	79 NX

Mucus-secreting cells	59 NX
Colon	70 NX
Small intestine	68 NX
Rectum	58 NX

Muller glia cells	42 NX
Eye	42 NX

Pancreatic endocrine cells	65 NX
Pancreas	65 NX

Paneth cells	52 NX
Colon	98 NX
Rectum	52 NX
Small intestine	39 NX

Peritubular cells	23 NX
Testis	23 NX

Proximal tubular cells	305 NX
Kidney	305 NX

Rod photoreceptor cells	32 NX
Eye	32 NX

Sertoli cells	7 NX
Testis	7 NX

Smooth muscle cells	33 NX
Pancreas	92 NX
Skin	34 NX
Heart muscle	31 NX
Prostate	23 NX

Spermatocytes	86 NX
Testis	86 NX

Spermatogonia	74 NX
Testis	74 NX

Suprabasal keratinocytes	30 NX
Skin	30 NX

Syncytiotrophoblasts	55 NX
Placenta	55 NX

T-cells	61 NX
Kidney	114 NX
Skin	77 NX
Colon	72 NX
Prostate	61 NX
Lung	60 NX
Liver	45 NX

Undifferentiated cells	68 NX
Small intestine	90 NX
Rectum	61 NX
Colon	59 NX

Urothelial cells	48 NX
Prostate	48 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.