Expression of HSPB1 in testis cancer - The Human Protein Atlas

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HSPB1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

TESTIS CANCER - Interactive survival scatter plotⁱ

The Survival Scatter plot shows the clinical status (i.e. dead or alive) for all individuals in the patient cohort, based on the same data that underlies the corresponding Kaplan-Meier plots. Patients that are alive at last time for follow-up are shown in blue and patients who have died during the study are shown in red.

The x-axis shows the expression levels (FPKM) of the investigated gene in the tumor tissue at the time of diagnosis. The y-axis shows the follow-up time after diagnosis (years). Both axes are complimented with kernel density curves demonstrating the data density over the axes. The top density plot shows the expression levels (FPKM) distribution among dead (red) and alive patients (blue). The right density plot shows the data density of the survived years of dead patients with high and low expression levels respectively, stratified using the cutoff indicated by the vertical dashed line through the Survival Scatter plot. This cutoff is automatically defined based on the FPKM cutoff that minimizes the p-score. The cutoff can be changed by dragging the vertical line or by entering a cutoff value in the square labeled "Current cut-off".

Under the Survival Scatter plot the p-score landscape (black curve; left axis) is shown together with dead median separation (red curve; right axis). Dead median separation is the difference in median mRNA expression between patients who have died with high and low expression, respectively. It is calculated as follows: median FPKM expression of dead patients with high expression - median FPKM expression of dead patients with low expression. This is intended to aid the user in visually exploring custom cutoffs and the associated p-scores and dead median separation.

Individual patient data is displayed and can be filtered by clicking on one or more of the category buttons on the top of the page. Categories describing expression level and patient information include: high, low, alive, dead, female, male and tumor stages. The scale of the x-axis can be toggled between linear and log-scale by clicking on the "x log" button. Mouse-over function shows TCGA ID, patient information and mRNA expression (FPKM) for each patient.

& Survival analysisⁱ

HSPB1 is not prognostic in testis cancer

Stage:

Survival analysis

Current cut offⁱ:
Best expression cut offⁱ: 264.67
Median expressionⁱ: N/A
Median follow up timeⁱ: N/A
P scoreⁱ N/A
5-year survival highⁱ N/A
5-year survival lowⁱ N/A

TCGA RNA samplesⁱ

Average FPKM

202.6

Number of samples

134

Samples

Sample	Description	FPKM
TCGA-2G-AAGW-01A	38 years, male, white, stage:is, alive, 4899 days	845.6
TCGA-SN-A84X-01A	21 years, male, white, stage:is, alive, 312 days	830.1
TCGA-2G-AAFN-01A	26 years, male, white, stage:iiib, alive, 773 days	752.1
TCGA-2G-AAFM-01A	31 years, male, white, stage:iia, alive, 503 days	647.6
TCGA-2G-AAGV-01A	23 years, male, white, alive, 4527 days	641.5
TCGA-2G-AAG8-01A	21 years, male, white, stage:ib, alive, 2289 days	556.9
TCGA-ZM-AA0N-01A	44 years, male, white, stage:ib, alive, 634 days	533.4
TCGA-2G-AAGN-01A	41 years, male, white, stage:iiib, alive, 3656 days	467.6
TCGA-VF-A8AD-01A	36 years, male, white, stage:ib, alive, 1006 days	458.6
TCGA-2G-AAL7-01A	32 years, male, white, stage:is, alive, 3991 days	449.7
TCGA-2G-AAKD-01A	18 years, male, white, stage:iii, alive, 6340 days	423.7
TCGA-VF-A8A9-01A	31 years, male, white, stage:ia, alive, 1119 days	411.4
TCGA-2G-AAKL-01A	26 years, male, white, stage:ii, alive, 7023 days	393.3
TCGA-2G-AALP-01A	43 years, male, white, stage:iiib, alive, 2645 days	388.4
TCGA-2G-AAG0-01A	23 years, male, white, stage:is, alive, 1529 days	364.5
TCGA-XY-A8S3-01B	24 years, male, white, stage:is, alive, 843 days	350.6
TCGA-2G-AAGE-01A	21 years, male, white, stage:is, alive, 2478 days	347.2
TCGA-2G-AAFI-01A	41 years, male, white, stage:ib, alive, 675 days	323.8
TCGA-2G-AAFO-01A	33 years, male, white, stage:iia, alive, 685 days	323.7
TCGA-2G-AAGO-01A	41 years, male, white, stage:is, alive, 4026 days	315.2
TCGA-SN-A84Y-01A	18 years, male, white, stage:is, alive, 524 days	297.1
TCGA-ZM-AA0H-01A	50 years, male, white, stage:is, alive, 1736 days	297.0
TCGA-2G-AAG6-01A	24 years, male, white, stage:is, alive, 2231 days	296.2
TCGA-2X-A9D5-01A	49 years, male, white, stage:i, alive, 435 days	292.3
TCGA-2G-AAFL-01A	35 years, male, white, stage:ib, alive, 750 days	279.4
TCGA-2G-AAKG-01A	22 years, male, white, stage:i, alive, 6598 days	270.1
TCGA-2G-AAGJ-01A	28 years, male, black or african american, stage:ia, alive, 2938 days	267.0
TCGA-2G-AAH0-01A	30 years, male, white, stage:is, alive, 5477 days	266.6
TCGA-2G-AAF8-01A	33 years, male, white, stage:ia, alive, 3911 days	266.3
TCGA-2G-AAKM-01A	14 years, male, white, stage:ii, dead, 6972 days	263.1
TCGA-XY-A8S2-01A	67 years, male, white, stage:i, alive, 672 days	261.9
TCGA-YU-A94D-01A	28 years, male, stage:iiib, alive, 2167 days	251.7
TCGA-2G-AAGA-01A	38 years, male, white, stage:iia, alive, 2439 days	251.4
TCGA-2G-AAFY-01A	24 years, male, white, stage:iia, alive, 1099 days	249.4
TCGA-VF-A8AE-01A	39 years, male, white, stage:ia, alive, 727 days	246.1
TCGA-2G-AAFZ-01A	32 years, male, white, stage:iii, alive, 1353 days	236.6
TCGA-XE-A8H1-01A	24 years, male, white, stage:is, alive, 209 days	234.3
TCGA-2G-AAGZ-01A	27 years, male, white, stage:iiia, alive, 5233 days	233.5
TCGA-ZM-AA0B-01A	32 years, male, white, stage:ia, alive, 838 days	226.8
TCGA-2G-AAG7-01A	33 years, male, white, stage:is, alive, 2475 days	221.8
TCGA-W4-A7U4-01A	23 years, male, white, alive, 738 days	221.7
TCGA-2G-AAGP-01A	33 years, male, white, stage:iia, alive, 4018 days	219.5
TCGA-XE-AAOD-01A	39 years, male, white, stage:ib, alive, 2058 days	216.2
TCGA-X3-A8G4-01A	33 years, male, white, stage:is, alive, 856 days	215.3
TCGA-YU-A90Y-01A	23 years, male, black or african american, stage:iiic, dead, 17 days	211.9
TCGA-2G-AAGF-01A	28 years, male, white, stage:is, alive, 2734 days	208.5
TCGA-2G-AAG5-01A	36 years, male, white, stage:is, alive, 2299 days	203.1
TCGA-WZ-A7V3-01A	20 years, male, white, stage:i, alive, 753 days	201.4
TCGA-2G-AAH4-01A	34 years, male, white, stage:ii, alive, 6210 days	199.4
TCGA-XE-AAOL-01A	38 years, male, black or african american, stage:i, alive, 13 days	193.3
TCGA-2G-AAHG-01A	25 years, male, white, stage:i, alive, 1819 days	192.5
TCGA-2G-AAFE-01A	37 years, male, white, stage:iia, alive, 4702 days	192.1
TCGA-2G-AAGX-01A	22 years, male, white, stage:ia, alive, 5514 days	190.7
TCGA-2G-AAGC-01A	28 years, male, white, stage:is, alive, 2585 days	190.0
TCGA-4K-AAAL-01A	31 years, male, white, stage:is, alive, 483 days	188.0
TCGA-2G-AAHP-01A	31 years, male, white, stage:is, alive, 5667 days	185.4
TCGA-2G-AAGK-01A	20 years, male, white, stage:is, alive, 3621 days	185.3
TCGA-4K-AA1I-01A	26 years, male, white, stage:ia, alive, 3 days	184.9
TCGA-2G-AAH8-01A	45 years, male, white, stage:iiic, alive, 2248 days	183.1
TCGA-SO-A8JP-01A	29 years, male, white, stage:i, alive, 540 days	177.7
TCGA-ZM-AA0E-01A	39 years, male, white, stage:ia, alive, 811 days	177.6
TCGA-2G-AAL5-01A	31 years, male, white, stage:i, alive, 7437 days	173.4
TCGA-2G-AAGS-01A	39 years, male, white, stage:iiib, alive, 4816 days	168.2
TCGA-2G-AAGT-01A	30 years, male, white, stage:is, alive, 4406 days	167.9
TCGA-2G-AAHL-01A	26 years, male, white, stage:i, alive, 7081 days	164.6
TCGA-2G-AAGY-01A	28 years, male, white, stage:is, alive, 5329 days	162.2
TCGA-ZM-AA05-01A	36 years, male, white, stage:iic, alive, 1126 days	161.5
TCGA-2G-AAHT-01A	32 years, male, white, stage:is, alive, 542 days	160.3
TCGA-XE-AANJ-01A	39 years, male, white, stage:is, alive, 2007 days	155.8
TCGA-XE-AAOC-01A	31 years, male, white, stage:ia, alive, 270 days	155.3
TCGA-VF-A8A8-01A	18 years, male, white, stage:ia, alive, 1131 days	154.8
TCGA-SN-A6IS-01A	26 years, male, white, stage:is, alive, 496 days	150.6
TCGA-YU-A90S-01A	26 years, male, white, stage:ia, alive, 971 days	150.2
TCGA-XE-AANI-01A	37 years, male, white, stage:is, alive, 1041 days	149.8
TCGA-XE-AAOB-01A	27 years, male, white, stage:is, dead, 513 days	149.1
TCGA-ZM-AA0D-01A	34 years, male, white, stage:ia, alive, 848 days	146.6
TCGA-S6-A8JY-01A	27 years, male, white, stage:is, alive, 278 days	142.1
TCGA-2G-AAGG-01A	20 years, male, white, stage:iiic, alive, 2611 days	141.3
TCGA-2G-AAHN-01A	32 years, male, white, stage:i, alive, 6445 days	137.3
TCGA-XE-AAO6-01A	47 years, male, white, stage:ia, alive, 240 days	136.7
TCGA-2G-AAG3-01A	53 years, male, white, stage:is, alive, 1593 days	136.1
TCGA-2G-AAFG-01A	30 years, male, white, stage:is, alive, 6183 days	135.5
TCGA-YU-A912-01A	34 years, male, black or african american, stage:iiic, alive, 866 days	134.6
TCGA-2G-AAHC-01A	33 years, male, white, stage:is, alive, 5539 days	134.4
TCGA-SN-A84W-01A	30 years, male, white, stage:is, alive, 293 days	133.8
TCGA-XE-A8H4-01A	23 years, male, white, stage:ia, alive, 559 days	133.7
TCGA-2G-AAGI-01A	33 years, male, white, stage:is, alive, 3137 days	132.7
TCGA-2G-AAH2-01A	20 years, male, white, stage:is, alive, 6060 days	128.4
TCGA-2G-AAFV-01A	31 years, male, white, stage:is, alive, 1389 days	126.6
TCGA-XE-AAO4-01A	40 years, male, white, stage:ia, alive, 367 days	122.2
TCGA-2G-AAEX-01A	38 years, male, white, stage:is, alive, 1259 days	118.8
TCGA-4K-AA1H-01A	26 years, male, white, stage:ia, alive, 518 days	118.5
TCGA-XE-A8H5-01A	29 years, male, stage:is, alive, 1217 days	116.6
TCGA-ZM-AA0F-01A	35 years, male, white, stage:ia, alive, 681 days	116.3
TCGA-2G-AAFJ-01A	23 years, male, asian, alive, 792 days	115.1
TCGA-VF-A8AB-01A	31 years, male, black or african american, stage:ia, alive, 760 days	114.7
TCGA-XY-A9T9-01A	37 years, male, white, stage:is, alive, 281 days	113.2
TCGA-2G-AAKH-01A	19 years, male, white, stage:ii, alive, 6862 days	111.2
TCGA-SB-A76C-01A	38 years, male, white, alive, 42 days	108.4
TCGA-2G-AAG9-01A	25 years, male, white, stage:iiib, alive, 2234 days	106.2
TCGA-XE-AAOF-01A	50 years, male, asian, stage:ia, alive, 1268 days	106.0
TCGA-ZM-AA06-01A	45 years, male, white, stage:ib, alive, 1498 days	105.7
TCGA-XE-AAOJ-01A	24 years, male, white, stage:is, alive, 1550 days	103.1
TCGA-W4-A7U3-01A	26 years, male, white, alive, 149 days	103.0
TCGA-WZ-A7V4-01A	28 years, male, white, stage:i, alive, 894 days	102.4
TCGA-SB-A6J6-01A	22 years, male, white, stage:ia, alive, 413 days	101.0
TCGA-S6-A8JX-01A	27 years, male, white, stage:ib, alive, 552 days	100.8
TCGA-YU-AA4L-01A	27 years, male, black or african american, stage:iiic, alive, 1573 days	99.7
TCGA-2G-AAEW-01A	31 years, male, white, stage:is, dead, 618 days	95.4
TCGA-YU-AA61-01A	29 years, male, white, stage:is, alive, 864 days	95.1
TCGA-2G-AAGM-01A	51 years, male, white, stage:is, alive, 3891 days	90.4
TCGA-YU-A90P-01A	25 years, male, white, stage:ia, alive, 2069 days	87.0
TCGA-YU-A90W-01A	45 years, male, white, stage:ia, alive, 1113 days	83.7
TCGA-2G-AAF4-01A	30 years, male, white, stage:i, alive, 2315 days	77.3
TCGA-2G-AAF6-01A	28 years, male, white, stage:is, alive, 3491 days	77.2
TCGA-WZ-A7V5-01A	27 years, male, white, stage:i, alive, 1061 days	74.3
TCGA-XE-AANR-01A	24 years, male, white, stage:i, alive, 14 days	74.1
TCGA-XE-A9SE-01A	35 years, male, white, stage:ia, alive, 708 days	74.1
TCGA-VF-A8AC-01A	29 years, male, white, stage:ia, alive, 1083 days	74.0
TCGA-YU-A94I-01A	66 years, male, stage:ia, alive, 536 days	72.0
TCGA-2G-AAHA-01A	48 years, male, white, stage:ib, alive, 3349 days	69.2
TCGA-XE-AANV-01A	52 years, male, stage:ib, alive, 1701 days	67.4
TCGA-2G-AAF1-01A	28 years, male, asian, stage:is, alive, 1403 days	65.5
TCGA-WZ-A8D5-01A	38 years, male, white, alive, 774 days	64.4
TCGA-W4-A7U2-01A	26 years, male, white, alive, 1263 days	62.4
TCGA-4K-AA1G-01A	34 years, male, white, stage:is, alive, 436 days	61.3
TCGA-XE-AAO3-01A	33 years, male, asian, stage:i, alive, 2857 days	57.1
TCGA-VF-A8AA-01A	51 years, male, white, stage:i, alive, 1146 days	56.5
TCGA-XY-A89B-01A	35 years, male, white, stage:ia, alive, 471 days	56.1
TCGA-S6-A8JW-01A	37 years, male, white, stage:is, alive, 698 days	54.1
TCGA-2G-AAFH-01A	38 years, male, white, stage:iib, alive, 1375 days	54.0
TCGA-YU-A90Q-01A	21 years, male, stage:ib, alive, 1964 days	53.8
TCGA-2G-AAH3-01A	20 years, male, white, stage:i, alive, 1822 days	47.9
TCGA-2X-A9D6-01A	42 years, male, white, stage:i, alive, 607 days	34.4
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TESTIS CANCER - Protein expressionⁱ A mouse-over function shows sample information and annotation data. Click on an image to view it in a full screen mode. Samples can be filtered based on level of antibody staining by selecting one or several of the following categories: high, medium, low and not detected. The assay and annotation is described here. Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset.

Antibody stainingⁱ Antibody staining in the annotated cell types in the current human tissue is reported as not detected, low, medium, or high. This score is based on the staining intensity and fraction of stained cells. Read more	Antibody HPA000497	Antibody CAB004439	Antibody CAB047331
Staining
High
Medium
Low
Not detected
Intensity
Strong
Moderate
Weak
Negative
Quantity
>75%
75%-25%
<25%
None
Location
Nuclear
Cytoplasmic/membranous
Cytoplasmic/membranous,nuclear
None
Click images for details

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.