Cell type atlas - HIBADH - The Human Protein Atlas

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HIBADH

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	HIBADH
Gene descriptionⁱ Full gene name according to HGNC.	3-hydroxyisobutyrate dehydrogenase
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Distal tubular cells, Proximal tubular cells, Syncytiotrophoblasts)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Distal tubular cells, Proximal tubular cells, Syncytiotrophoblasts)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	9 NX
Lung	9 NX

Alveolar cells type 2	5 NX
Lung	5 NX

B-cells	12 NX
Kidney	18 NX
Colon	15 NX
Liver	5 NX

Basal glandular cells	31 NX
Prostate	31 NX

Basal keratinocytes	19 NX
Skin	19 NX

Bipolar cells	15 NX
Eye	15 NX

Cardiomyocytes	94 NX
Heart muscle	94 NX

Cholangiocytes	38 NX
Liver	38 NX

Ciliated cells	32 NX
Lung	32 NX

Club cells	13 NX
Lung	13 NX

Collecting duct cells	45 NX
Kidney	45 NX

Cone photoreceptor cells	4 NX
Eye	4 NX

Cytotrophoblasts	135 NX
Placenta	134 NX

Distal tubular cells	461 NX
Kidney	461 NX

Ductal cells	27 NX
Pancreas	27 NX

Early spermatids	47 NX
Testis	47 NX

Endothelial cells	20 NX
Placenta	45 NX
Heart muscle	37 NX
Testis	24 NX
Liver	20 NX
Skin	20 NX
Prostate	12 NX
Eye	12 NX
Pancreas	11 NX
Lung	9 NX

Enterocytes	28 NX
Small intestine	51 NX
Rectum	30 NX
Colon	12 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	26 NX
Pancreas	26 NX

Extravillous trophoblasts	108 NX
Placenta	108 NX

Fibroblasts	50 NX
Placenta	63 NX
Heart muscle	47 NX
Skin	46 NX
Prostate	28 NX
Lung	16 NX

Glandular cells	41 NX
Prostate	41 NX

Granulocytes	2 NX
Lung	5 NX
Colon	0 NX

Hepatocytes	140 NX
Liver	140 NX

Hofbauer cells	46 NX
Placenta	46 NX

Horizontal cells	22 NX
Eye	22 NX

Intestinal endocrine cells	15 NX
Rectum	16 NX
Colon	14 NX

Ito cells	22 NX
Liver	22 NX

Kupffer cells	27 NX
Liver	27 NX

Late spermatids	46 NX
Testis	46 NX

Leydig cells	41 NX
Testis	41 NX

Macrophages	17 NX
Kidney	35 NX
Pancreas	19 NX
Prostate	17 NX
Testis	16 NX
Skin	12 NX
Lung	10 NX

Melanocytes	62 NX
Skin	62 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	11 NX
Pancreas	11 NX

Mucus-secreting cells	27 NX
Rectum	34 NX
Small intestine	27 NX
Colon	16 NX

Muller glia cells	30 NX
Eye	30 NX

Pancreatic endocrine cells	26 NX
Pancreas	26 NX

Paneth cells	25 NX
Rectum	27 NX
Small intestine	25 NX
Colon	14 NX

Peritubular cells	35 NX
Testis	35 NX

Proximal tubular cells	261 NX
Kidney	261 NX

Rod photoreceptor cells	9 NX
Eye	9 NX

Sertoli cells	45 NX
Testis	45 NX

Smooth muscle cells	38 NX
Skin	53 NX
Heart muscle	38 NX
Prostate	34 NX
Pancreas	26 NX

Spermatocytes	28 NX
Testis	28 NX

Spermatogonia	48 NX
Testis	48 NX

Suprabasal keratinocytes	14 NX
Skin	14 NX

Syncytiotrophoblasts	228 NX
Placenta	228 NX

T-cells	12 NX
Kidney	34 NX
Colon	16 NX
Liver	15 NX
Skin	12 NX
Prostate	9 NX
Lung	9 NX

Undifferentiated cells	40 NX
Small intestine	44 NX
Rectum	38 NX
Colon	26 NX

Urothelial cells	44 NX
Prostate	44 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.