Cell type atlas - KXD1 - The Human Protein Atlas

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KXD1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	KXD1
Gene descriptionⁱ Full gene name according to HGNC.	KxDL motif containing 1
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	15

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	18 NX
Lung	18 NX

Alveolar cells type 2	34 NX
Lung	34 NX

B-cells	41 NX
Kidney	54 NX
Liver	38 NX
Colon	28 NX

Basal glandular cells	62 NX
Prostate	62 NX

Basal keratinocytes	31 NX
Skin	31 NX

Bipolar cells	20 NX
Eye	20 NX

Cardiomyocytes	4 NX
Heart muscle	4 NX

Cholangiocytes	28 NX
Liver	28 NX

Ciliated cells	19 NX
Lung	19 NX

Club cells	25 NX
Lung	25 NX

Collecting duct cells	16 NX
Kidney	16 NX

Cone photoreceptor cells	12 NX
Eye	12 NX

Cytotrophoblasts	92 NX
Placenta	92 NX

Distal tubular cells	68 NX
Kidney	68 NX

Ductal cells	74 NX
Pancreas	74 NX

Early spermatids	156 NX
Testis	156 NX

Endothelial cells	50 NX
Placenta	97 NX
Prostate	90 NX
Pancreas	79 NX
Skin	60 NX
Liver	59 NX
Testis	50 NX
Eye	39 NX
Lung	29 NX
Heart muscle	5 NX

Enterocytes	49 NX
Small intestine	57 NX
Colon	49 NX
Rectum	33 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	99 NX
Pancreas	99 NX

Extravillous trophoblasts	104 NX
Placenta	104 NX

Fibroblasts	58 NX
Prostate	78 NX
Placenta	77 NX
Skin	52 NX
Lung	27 NX
Heart muscle	4 NX

Glandular cells	68 NX
Prostate	68 NX

Granulocytes	43 NX
Colon	46 NX
Lung	40 NX

Hepatocytes	31 NX
Liver	31 NX

Hofbauer cells	109 NX
Placenta	109 NX

Horizontal cells	16 NX
Eye	16 NX

Intestinal endocrine cells	41 NX
Colon	48 NX
Rectum	35 NX

Ito cells	45 NX
Liver	45 NX

Kupffer cells	51 NX
Liver	51 NX

Late spermatids	26 NX
Testis	26 NX

Leydig cells	31 NX
Testis	31 NX

Macrophages	51 NX
Pancreas	94 NX
Kidney	59 NX
Prostate	52 NX
Testis	50 NX
Skin	49 NX
Lung	31 NX

Melanocytes	56 NX
Skin	56 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	152 NX
Pancreas	152 NX

Mucus-secreting cells	43 NX
Colon	54 NX
Small intestine	50 NX
Rectum	37 NX

Muller glia cells	23 NX
Eye	23 NX

Pancreatic endocrine cells	81 NX
Pancreas	81 NX

Paneth cells	41 NX
Colon	58 NX
Rectum	41 NX
Small intestine	28 NX

Peritubular cells	28 NX
Testis	28 NX

Proximal tubular cells	43 NX
Kidney	43 NX

Rod photoreceptor cells	16 NX
Eye	16 NX

Sertoli cells	39 NX
Testis	39 NX

Smooth muscle cells	56 NX
Pancreas	108 NX
Prostate	65 NX
Skin	49 NX
Heart muscle	6 NX

Spermatocytes	29 NX
Testis	29 NX

Spermatogonia	20 NX
Testis	20 NX

Suprabasal keratinocytes	36 NX
Skin	36 NX

Syncytiotrophoblasts	93 NX
Placenta	93 NX

T-cells	49 NX
Kidney	64 NX
Liver	51 NX
Colon	49 NX
Skin	31 NX
Prostate	31 NX
Lung	29 NX

Undifferentiated cells	44 NX
Small intestine	53 NX
Colon	44 NX
Rectum	36 NX

Urothelial cells	59 NX
Prostate	59 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.