Cell type atlas - PLD3 - The Human Protein Atlas

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PLD3

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PLD3
Gene descriptionⁱ Full gene name according to HGNC.	Phospholipase D family member 3
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	14

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Hofbauer cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enriched (basophil)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Hofbauer cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	30 NX
Lung	30 NX

Alveolar cells type 2	63 NX
Lung	63 NX

B-cells	34 NX
Liver	43 NX
Kidney	27 NX
Colon	22 NX

Basal glandular cells	71 NX
Prostate	71 NX

Basal keratinocytes	32 NX
Skin	32 NX

Bipolar cells	99 NX
Eye	99 NX

Cardiomyocytes	19 NX
Heart muscle	19 NX

Cholangiocytes	26 NX
Liver	26 NX

Ciliated cells	12 NX
Lung	12 NX

Club cells	28 NX
Lung	28 NX

Collecting duct cells	54 NX
Kidney	54 NX

Cone photoreceptor cells	31 NX
Eye	31 NX

Cytotrophoblasts	138 NX
Placenta	138 NX

Distal tubular cells	18 NX
Kidney	18 NX

Ductal cells	51 NX
Pancreas	51 NX

Early spermatids	6 NX
Testis	6 NX

Endothelial cells	47 NX
Placenta	94 NX
Eye	65 NX
Liver	63 NX
Skin	52 NX
Testis	50 NX
Pancreas	39 NX
Prostate	29 NX
Lung	20 NX
Heart muscle	16 NX

Enterocytes	53 NX
Small intestine	62 NX
Colon	46 NX
Rectum	34 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	51 NX
Pancreas	51 NX

Extravillous trophoblasts	95 NX
Placenta	95 NX

Fibroblasts	142 NX
Placenta	247 NX
Skin	133 NX
Prostate	103 NX
Heart muscle	39 NX
Lung	16 NX

Glandular cells	49 NX
Prostate	49 NX

Granulocytes	60 NX
Colon	83 NX
Lung	37 NX

Hepatocytes	36 NX
Liver	36 NX

Hofbauer cells	638 NX
Placenta	638 NX

Horizontal cells	114 NX
Eye	114 NX

Intestinal endocrine cells	70 NX
Rectum	89 NX
Colon	51 NX

Ito cells	91 NX
Liver	91 NX

Kupffer cells	220 NX
Liver	220 NX

Late spermatids	9 NX
Testis	9 NX

Leydig cells	140 NX
Testis	140 NX

Macrophages	84 NX
Pancreas	763 NX
Prostate	167 NX
Testis	114 NX
Kidney	84 NX
Skin	67 NX
Lung	55 NX

Melanocytes	88 NX
Skin	88 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	44 NX
Pancreas	44 NX

Mucus-secreting cells	37 NX
Colon	38 NX
Small intestine	37 NX
Rectum	35 NX

Muller glia cells	100 NX
Eye	100 NX

Pancreatic endocrine cells	50 NX
Pancreas	50 NX

Paneth cells	41 NX
Small intestine	49 NX
Rectum	41 NX
Colon	26 NX

Peritubular cells	135 NX
Testis	135 NX

Proximal tubular cells	30 NX
Kidney	30 NX

Rod photoreceptor cells	39 NX
Eye	39 NX

Sertoli cells	19 NX
Testis	19 NX

Smooth muscle cells	53 NX
Pancreas	101 NX
Skin	53 NX
Prostate	53 NX
Heart muscle	13 NX

Spermatocytes	14 NX
Testis	14 NX

Spermatogonia	58 NX
Testis	58 NX

Suprabasal keratinocytes	29 NX
Skin	29 NX

Syncytiotrophoblasts	164 NX
Placenta	164 NX

T-cells	35 NX
Prostate	44 NX
Liver	43 NX
Skin	35 NX
Colon	28 NX
Kidney	27 NX
Lung	23 NX

Undifferentiated cells	35 NX
Rectum	47 NX
Colon	33 NX
Small intestine	31 NX

Urothelial cells	52 NX
Prostate	52 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.