Cell type atlas - FBL - The Human Protein Atlas

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FBL

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	FBL
Gene descriptionⁱ Full gene name according to HGNC.	Fibrillarin
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	8

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Late spermatids)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Late spermatids)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	30 NX
Lung	30 NX

Alveolar cells type 2	47 NX
Lung	47 NX

B-cells	169 NX
Colon	178 NX
Liver	163 NX
Kidney	160 NX

Basal glandular cells	252 NX
Prostate	252 NX

Basal keratinocytes	311 NX
Skin	311 NX

Bipolar cells	18 NX
Eye	18 NX

Cardiomyocytes	34 NX
Heart muscle	34 NX

Cholangiocytes	94 NX
Liver	94 NX

Ciliated cells	48 NX
Lung	48 NX

Club cells	73 NX
Lung	73 NX

Collecting duct cells	38 NX
Kidney	38 NX

Cone photoreceptor cells	24 NX
Eye	24 NX

Cytotrophoblasts	119 NX
Placenta	119 NX

Distal tubular cells	63 NX
Kidney	63 NX

Ductal cells	77 NX
Pancreas	77 NX

Early spermatids	367 NX
Testis	367 NX

Endothelial cells	115 NX
Prostate	197 NX
Skin	172 NX
Testis	142 NX
Liver	137 NX
Pancreas	115 NX
Placenta	102 NX
Lung	32 NX
Eye	31 NX
Heart muscle	28 NX

Enterocytes	42 NX
Small intestine	52 NX
Colon	40 NX
Rectum	33 NX

Erythroid cells	94 NX
Liver	94 NX

Exocrine glandular cells	165 NX
Pancreas	165 NX

Extravillous trophoblasts	258 NX
Placenta	258 NX

Fibroblasts	111 NX
Prostate	129 NX
Skin	114 NX
Lung	79 NX
Placenta	79 NX
Heart muscle	21 NX

Glandular cells	104 NX
Prostate	104 NX

Granulocytes	96 NX
Colon	138 NX
Lung	54 NX

Hepatocytes	47 NX
Liver	47 NX

Hofbauer cells	92 NX
Placenta	92 NX

Horizontal cells	14 NX
Eye	14 NX

Intestinal endocrine cells	89 NX
Colon	92 NX
Rectum	87 NX

Ito cells	84 NX
Liver	84 NX

Kupffer cells	86 NX
Liver	86 NX

Late spermatids	598 NX
Testis	598 NX

Leydig cells	109 NX
Testis	109 NX

Macrophages	93 NX
Skin	127 NX
Prostate	127 NX
Testis	101 NX
Kidney	92 NX
Lung	49 NX
Pancreas	30 NX

Melanocytes	93 NX
Skin	93 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	108 NX
Pancreas	108 NX

Mucus-secreting cells	160 NX
Colon	169 NX
Rectum	151 NX
Small intestine	112 NX

Muller glia cells	19 NX
Eye	19 NX

Pancreatic endocrine cells	98 NX
Pancreas	98 NX

Paneth cells	53 NX
Rectum	170 NX
Small intestine	53 NX
Colon	37 NX

Peritubular cells	74 NX
Testis	74 NX

Proximal tubular cells	60 NX
Kidney	60 NX

Rod photoreceptor cells	20 NX
Eye	20 NX

Sertoli cells	71 NX
Testis	71 NX

Smooth muscle cells	130 NX
Skin	164 NX
Prostate	152 NX
Pancreas	112 NX
Heart muscle	34 NX

Spermatocytes	32 NX
Testis	32 NX

Spermatogonia	76 NX
Testis	76 NX

Suprabasal keratinocytes	289 NX
Skin	289 NX

Syncytiotrophoblasts	102 NX
Placenta	102 NX

T-cells	141 NX
Liver	169 NX
Colon	147 NX
Kidney	141 NX
Skin	120 NX
Prostate	118 NX
Lung	62 NX

Undifferentiated cells	250 NX
Colon	274 NX
Small intestine	250 NX
Rectum	221 NX

Urothelial cells	202 NX
Prostate	202 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.