Cell type atlas - ILVBL - The Human Protein Atlas

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ILVBL

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ILVBL
Gene descriptionⁱ Full gene name according to HGNC.	IlvB acetolactate synthase like
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Syncytiotrophoblasts)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Syncytiotrophoblasts)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	24 NX
Lung	24 NX

Alveolar cells type 2	9 NX
Lung	9 NX

B-cells	11 NX
Kidney	13 NX
Liver	11 NX
Colon	9 NX

Basal glandular cells	19 NX
Prostate	19 NX

Basal keratinocytes	11 NX
Skin	11 NX

Bipolar cells	91 NX
Eye	91 NX

Cardiomyocytes	29 NX
Heart muscle	29 NX

Cholangiocytes	59 NX
Liver	59 NX

Ciliated cells	12 NX
Lung	12 NX

Club cells	9 NX
Lung	9 NX

Collecting duct cells	24 NX
Kidney	24 NX

Cone photoreceptor cells	26 NX
Eye	26 NX

Cytotrophoblasts	78 NX
Placenta	78 NX

Distal tubular cells	17 NX
Kidney	17 NX

Ductal cells	40 NX
Pancreas	40 NX

Early spermatids	4 NX
Testis	4 NX

Endothelial cells	18 NX
Heart muscle	35 NX
Placenta	28 NX
Eye	24 NX
Pancreas	22 NX
Lung	20 NX
Liver	18 NX
Testis	17 NX
Prostate	15 NX
Skin	11 NX

Enterocytes	82 NX
Small intestine	102 NX
Colon	70 NX
Rectum	53 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	44 NX
Pancreas	44 NX

Extravillous trophoblasts	121 NX
Placenta	121 NX

Fibroblasts	16 NX
Placenta	44 NX
Skin	15 NX
Lung	12 NX
Prostate	12 NX
Heart muscle	9 NX

Glandular cells	18 NX
Prostate	18 NX

Granulocytes	11 NX
Lung	21 NX
Colon	0 NX

Hepatocytes	50 NX
Liver	50 NX

Hofbauer cells	39 NX
Placenta	39 NX

Horizontal cells	18 NX
Eye	18 NX

Intestinal endocrine cells	43 NX
Rectum	52 NX
Colon	34 NX

Ito cells	27 NX
Liver	27 NX

Kupffer cells	10 NX
Liver	10 NX

Late spermatids	4 NX
Testis	4 NX

Leydig cells	24 NX
Testis	24 NX

Macrophages	17 NX
Pancreas	37 NX
Prostate	24 NX
Kidney	17 NX
Lung	15 NX
Skin	13 NX
Testis	11 NX

Melanocytes	79 NX
Skin	79 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	4 NX
Pancreas	4 NX

Mucus-secreting cells	49 NX
Small intestine	73 NX
Colon	46 NX
Rectum	45 NX

Muller glia cells	51 NX
Eye	51 NX

Pancreatic endocrine cells	28 NX
Pancreas	28 NX

Paneth cells	53 NX
Small intestine	84 NX
Rectum	53 NX
Colon	49 NX

Peritubular cells	19 NX
Testis	19 NX

Proximal tubular cells	43 NX
Kidney	43 NX

Rod photoreceptor cells	30 NX
Eye	30 NX

Sertoli cells	19 NX
Testis	19 NX

Smooth muscle cells	19 NX
Pancreas	39 NX
Skin	20 NX
Heart muscle	16 NX
Prostate	12 NX

Spermatocytes	16 NX
Testis	16 NX

Spermatogonia	20 NX
Testis	20 NX

Suprabasal keratinocytes	14 NX
Skin	14 NX

Syncytiotrophoblasts	212 NX
Placenta	212 NX

T-cells	12 NX
Prostate	18 NX
Kidney	13 NX
Skin	12 NX
Liver	12 NX
Lung	10 NX
Colon	8 NX

Undifferentiated cells	66 NX
Small intestine	72 NX
Rectum	66 NX
Colon	60 NX

Urothelial cells	20 NX
Prostate	20 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.