Cell type atlas - HNRNPL - The Human Protein Atlas

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HNRNPL

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	HNRNPL
Gene descriptionⁱ Full gene name according to HGNC.	Heterogeneous nuclear ribonucleoprotein L
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	21 NX
Lung	21 NX

Alveolar cells type 2	58 NX
Lung	58 NX

B-cells	59 NX
Liver	75 NX
Kidney	67 NX
Colon	39 NX

Basal glandular cells	53 NX
Prostate	53 NX

Basal keratinocytes	32 NX
Skin	32 NX

Bipolar cells	76 NX
Eye	76 NX

Cardiomyocytes	16 NX
Heart muscle	16 NX

Cholangiocytes	20 NX
Liver	20 NX

Ciliated cells	25 NX
Lung	25 NX

Club cells	36 NX
Lung	36 NX

Collecting duct cells	21 NX
Kidney	21 NX

Cone photoreceptor cells	61 NX
Eye	61 NX

Cytotrophoblasts	36 NX
Placenta	36 NX

Distal tubular cells	7 NX
Kidney	7 NX

Ductal cells	30 NX
Pancreas	30 NX

Early spermatids	12 NX
Testis	12 NX

Endothelial cells	37 NX
Prostate	56 NX
Eye	53 NX
Lung	41 NX
Skin	40 NX
Liver	38 NX
Pancreas	32 NX
Placenta	23 NX
Heart muscle	22 NX
Testis	21 NX

Enterocytes	51 NX
Rectum	57 NX
Small intestine	49 NX
Colon	39 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	38 NX
Pancreas	38 NX

Extravillous trophoblasts	30 NX
Placenta	30 NX

Fibroblasts	33 NX
Prostate	44 NX
Heart muscle	37 NX
Lung	36 NX
Skin	35 NX
Placenta	27 NX

Glandular cells	50 NX
Prostate	50 NX

Granulocytes	38 NX
Lung	40 NX
Colon	37 NX

Hepatocytes	62 NX
Liver	62 NX

Hofbauer cells	24 NX
Placenta	24 NX

Horizontal cells	32 NX
Eye	32 NX

Intestinal endocrine cells	60 NX
Colon	65 NX
Rectum	56 NX

Ito cells	42 NX
Liver	42 NX

Kupffer cells	61 NX
Liver	61 NX

Late spermatids	9 NX
Testis	9 NX

Leydig cells	26 NX
Testis	26 NX

Macrophages	38 NX
Lung	54 NX
Pancreas	40 NX
Kidney	35 NX
Skin	35 NX
Prostate	29 NX
Testis	23 NX

Melanocytes	25 NX
Skin	25 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	32 NX
Pancreas	32 NX

Mucus-secreting cells	62 NX
Rectum	72 NX
Small intestine	62 NX
Colon	52 NX

Muller glia cells	42 NX
Eye	42 NX

Pancreatic endocrine cells	35 NX
Pancreas	35 NX

Paneth cells	35 NX
Rectum	57 NX
Small intestine	35 NX
Colon	32 NX

Peritubular cells	21 NX
Testis	21 NX

Proximal tubular cells	18 NX
Kidney	18 NX

Rod photoreceptor cells	69 NX
Eye	69 NX

Sertoli cells	19 NX
Testis	19 NX

Smooth muscle cells	36 NX
Prostate	49 NX
Skin	42 NX
Heart muscle	28 NX
Pancreas	26 NX

Spermatocytes	19 NX
Testis	19 NX

Spermatogonia	20 NX
Testis	20 NX

Suprabasal keratinocytes	42 NX
Skin	42 NX

Syncytiotrophoblasts	44 NX
Placenta	44 NX

T-cells	50 NX
Kidney	55 NX
Liver	55 NX
Colon	50 NX
Skin	42 NX
Lung	36 NX
Prostate	26 NX

Undifferentiated cells	63 NX
Rectum	73 NX
Small intestine	69 NX
Colon	46 NX

Urothelial cells	37 NX
Prostate	37 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.