Cell type atlas - ECH1 - The Human Protein Atlas

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ECH1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ECH1
Gene descriptionⁱ Full gene name according to HGNC.	Enoyl-CoA hydratase 1
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	7

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	80 NX
Lung	80 NX

Alveolar cells type 2	82 NX
Lung	82 NX

B-cells	123 NX
Kidney	174 NX
Liver	123 NX
Colon	76 NX

Basal glandular cells	166 NX
Prostate	166 NX

Basal keratinocytes	73 NX
Skin	73 NX

Bipolar cells	19 NX
Eye	19 NX

Cardiomyocytes	281 NX
Heart muscle	281 NX

Cholangiocytes	234 NX
Liver	234 NX

Ciliated cells	98 NX
Lung	98 NX

Club cells	74 NX
Lung	74 NX

Collecting duct cells	138 NX
Kidney	138 NX

Cone photoreceptor cells	16 NX
Eye	16 NX

Cytotrophoblasts	632 NX
Placenta	632 NX

Distal tubular cells	433 NX
Kidney	433 NX

Ductal cells	147 NX
Pancreas	147 NX

Early spermatids	45 NX
Testis	45 NX

Endothelial cells	83 NX
Placenta	146 NX
Testis	116 NX
Heart muscle	104 NX
Pancreas	100 NX
Liver	83 NX
Prostate	68 NX
Skin	67 NX
Lung	53 NX
Eye	50 NX

Enterocytes	265 NX
Small intestine	302 NX
Colon	265 NX
Rectum	186 NX

Erythroid cells	47 NX
Liver	47 NX

Exocrine glandular cells	80 NX
Pancreas	80 NX

Extravillous trophoblasts	307 NX
Placenta	307 NX

Fibroblasts	85 NX
Placenta	186 NX
Heart muscle	119 NX
Skin	80 NX
Prostate	61 NX
Lung	52 NX

Glandular cells	126 NX
Prostate	126 NX

Granulocytes	116 NX
Lung	149 NX
Colon	83 NX

Hepatocytes	461 NX
Liver	461 NX

Hofbauer cells	245 NX
Placenta	245 NX

Horizontal cells	35 NX
Eye	35 NX

Intestinal endocrine cells	182 NX
Colon	197 NX
Rectum	166 NX

Ito cells	93 NX
Liver	93 NX

Kupffer cells	111 NX
Liver	111 NX

Late spermatids	42 NX
Testis	42 NX

Leydig cells	121 NX
Testis	121 NX

Macrophages	102 NX
Kidney	166 NX
Pancreas	157 NX
Prostate	114 NX
Lung	104 NX
Testis	91 NX
Skin	81 NX

Melanocytes	138 NX
Skin	138 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	290 NX
Pancreas	290 NX

Mucus-secreting cells	227 NX
Colon	374 NX
Rectum	238 NX
Small intestine	183 NX

Muller glia cells	55 NX
Eye	55 NX

Pancreatic endocrine cells	110 NX
Pancreas	110 NX

Paneth cells	236 NX
Colon	250 NX
Rectum	236 NX
Small intestine	211 NX

Peritubular cells	134 NX
Testis	134 NX

Proximal tubular cells	660 NX
Kidney	660 NX

Rod photoreceptor cells	18 NX
Eye	18 NX

Sertoli cells	78 NX
Testis	78 NX

Smooth muscle cells	100 NX
Heart muscle	143 NX
Prostate	120 NX
Skin	97 NX
Pancreas	63 NX

Spermatocytes	79 NX
Testis	79 NX

Spermatogonia	48 NX
Testis	48 NX

Suprabasal keratinocytes	79 NX
Skin	79 NX

Syncytiotrophoblasts	486 NX
Placenta	486 NX

T-cells	140 NX
Kidney	201 NX
Liver	157 NX
Prostate	140 NX
Colon	111 NX
Lung	109 NX
Skin	82 NX

Undifferentiated cells	278 NX
Colon	359 NX
Rectum	278 NX
Small intestine	266 NX

Urothelial cells	180 NX
Prostate	180 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.