Cell type atlas - NUCB1 - The Human Protein Atlas

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NUCB1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	NUCB1
Gene descriptionⁱ Full gene name according to HGNC.	Nucleobindin 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Secreted
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Extracellular locationⁱ A possible secretion of the protein was predicted based on N-terminal signal sequence (signal peptide) predictions and transmembrane region predictions, and subsequently annotated for its local or systemic secretion based on literature, function, and protein and RNA expression data. Read more	Protein predicted to be secreted

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	39 NX
Lung	39 NX

Alveolar cells type 2	74 NX
Lung	74 NX

B-cells	44 NX
Liver	75 NX
Colon	46 NX
Kidney	36 NX

Basal glandular cells	51 NX
Prostate	51 NX

Basal keratinocytes	43 NX
Skin	43 NX

Bipolar cells	21 NX
Eye	21 NX

Cardiomyocytes	48 NX
Heart muscle	48 NX

Cholangiocytes	61 NX
Liver	61 NX

Ciliated cells	21 NX
Lung	21 NX

Club cells	35 NX
Lung	35 NX

Collecting duct cells	66 NX
Kidney	66 NX

Cone photoreceptor cells	14 NX
Eye	14 NX

Cytotrophoblasts	89 NX
Placenta	89 NX

Distal tubular cells	35 NX
Kidney	35 NX

Ductal cells	115 NX
Pancreas	115 NX

Early spermatids	6 NX
Testis	6 NX

Endothelial cells	86 NX
Placenta	181 NX
Skin	122 NX
Testis	122 NX
Liver	97 NX
Prostate	86 NX
Eye	83 NX
Pancreas	68 NX
Lung	47 NX
Heart muscle	39 NX

Enterocytes	281 NX
Small intestine	373 NX
Colon	169 NX
Rectum	86 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	104 NX
Pancreas	104 NX

Extravillous trophoblasts	125 NX
Placenta	125 NX

Fibroblasts	121 NX
Placenta	151 NX
Skin	124 NX
Prostate	60 NX
Lung	41 NX
Heart muscle	30 NX

Glandular cells	71 NX
Prostate	71 NX

Granulocytes	95 NX
Colon	129 NX
Lung	60 NX

Hepatocytes	109 NX
Liver	109 NX

Hofbauer cells	191 NX
Placenta	191 NX

Horizontal cells	19 NX
Eye	19 NX

Intestinal endocrine cells	71 NX
Rectum	75 NX
Colon	68 NX

Ito cells	107 NX
Liver	107 NX

Kupffer cells	123 NX
Liver	123 NX

Late spermatids	7 NX
Testis	7 NX

Leydig cells	102 NX
Testis	102 NX

Macrophages	89 NX
Pancreas	143 NX
Kidney	111 NX
Lung	98 NX
Prostate	95 NX
Testis	84 NX
Skin	69 NX

Melanocytes	96 NX
Skin	96 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	151 NX
Pancreas	151 NX

Mucus-secreting cells	84 NX
Colon	125 NX
Small intestine	94 NX
Rectum	82 NX

Muller glia cells	50 NX
Eye	50 NX

Pancreatic endocrine cells	92 NX
Pancreas	92 NX

Paneth cells	154 NX
Colon	164 NX
Small intestine	154 NX
Rectum	86 NX

Peritubular cells	117 NX
Testis	117 NX

Proximal tubular cells	115 NX
Kidney	115 NX

Rod photoreceptor cells	15 NX
Eye	14 NX

Sertoli cells	91 NX
Testis	91 NX

Smooth muscle cells	95 NX
Pancreas	107 NX
Prostate	102 NX
Skin	86 NX
Heart muscle	33 NX

Spermatocytes	11 NX
Testis	11 NX

Spermatogonia	47 NX
Testis	47 NX

Suprabasal keratinocytes	44 NX
Skin	44 NX

Syncytiotrophoblasts	85 NX
Placenta	85 NX

T-cells	89 NX
Kidney	101 NX
Prostate	100 NX
Liver	96 NX
Colon	78 NX
Skin	67 NX
Lung	63 NX

Undifferentiated cells	102 NX
Colon	118 NX
Small intestine	102 NX
Rectum	92 NX

Urothelial cells	56 NX
Prostate	56 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.