Cell type atlas - DCTN6 - The Human Protein Atlas

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DCTN6

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	DCTN6
Gene descriptionⁱ Full gene name according to HGNC.	Dynactin subunit 6
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	24 NX
Lung	24 NX

Alveolar cells type 2	31 NX
Lung	31 NX

B-cells	37 NX
Kidney	54 NX
Colon	40 NX
Liver	17 NX

Basal glandular cells	81 NX
Prostate	81 NX

Basal keratinocytes	51 NX
Skin	51 NX

Bipolar cells	34 NX
Eye	34 NX

Cardiomyocytes	73 NX
Heart muscle	73 NX

Cholangiocytes	46 NX
Liver	46 NX

Ciliated cells	58 NX
Lung	58 NX

Club cells	38 NX
Lung	38 NX

Collecting duct cells	42 NX
Kidney	42 NX

Cone photoreceptor cells	14 NX
Eye	14 NX

Cytotrophoblasts	76 NX
Placenta	76 NX

Distal tubular cells	105 NX
Kidney	105 NX

Ductal cells	78 NX
Pancreas	78 NX

Early spermatids	12 NX
Testis	12 NX

Endothelial cells	53 NX
Pancreas	86 NX
Placenta	84 NX
Prostate	63 NX
Skin	57 NX
Heart muscle	52 NX
Testis	51 NX
Eye	51 NX
Lung	50 NX
Liver	49 NX

Enterocytes	26 NX
Small intestine	30 NX
Colon	26 NX
Rectum	24 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	74 NX
Pancreas	74 NX

Extravillous trophoblasts	71 NX
Placenta	71 NX

Fibroblasts	56 NX
Placenta	89 NX
Skin	56 NX
Prostate	55 NX
Lung	42 NX
Heart muscle	37 NX

Glandular cells	41 NX
Prostate	41 NX

Granulocytes	46 NX
Colon	55 NX
Lung	37 NX

Hepatocytes	42 NX
Liver	42 NX

Hofbauer cells	62 NX
Placenta	62 NX

Horizontal cells	25 NX
Eye	25 NX

Intestinal endocrine cells	39 NX
Rectum	45 NX
Colon	34 NX

Ito cells	44 NX
Liver	44 NX

Kupffer cells	46 NX
Liver	46 NX

Late spermatids	7 NX
Testis	7 NX

Leydig cells	75 NX
Testis	75 NX

Macrophages	52 NX
Pancreas	61 NX
Skin	57 NX
Kidney	56 NX
Lung	46 NX
Testis	44 NX
Prostate	44 NX

Melanocytes	66 NX
Skin	66 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	66 NX
Pancreas	66 NX

Mucus-secreting cells	27 NX
Small intestine	35 NX
Rectum	26 NX
Colon	25 NX

Muller glia cells	43 NX
Eye	43 NX

Pancreatic endocrine cells	77 NX
Pancreas	77 NX

Paneth cells	39 NX
Colon	49 NX
Small intestine	39 NX
Rectum	29 NX

Peritubular cells	71 NX
Testis	71 NX

Proximal tubular cells	115 NX
Kidney	115 NX

Rod photoreceptor cells	36 NX
Eye	36 NX

Sertoli cells	52 NX
Testis	52 NX

Smooth muscle cells	70 NX
Heart muscle	88 NX
Pancreas	73 NX
Skin	67 NX
Prostate	62 NX

Spermatocytes	43 NX
Testis	43 NX

Spermatogonia	48 NX
Testis	48 NX

Suprabasal keratinocytes	56 NX
Skin	56 NX

Syncytiotrophoblasts	170 NX
Placenta	170 NX

T-cells	41 NX
Colon	108 NX
Skin	100 NX
Prostate	52 NX
Kidney	47 NX
Liver	34 NX
Lung	32 NX

Undifferentiated cells	29 NX
Colon	38 NX
Small intestine	29 NX
Rectum	25 NX

Urothelial cells	81 NX
Prostate	81 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.