Cell type atlas - SQLE - The Human Protein Atlas

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SQLE

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SQLE
Gene descriptionⁱ Full gene name according to HGNC.	Squalene epoxidase
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes FDA approved drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	57 NX
Lung	57 NX

Alveolar cells type 2	84 NX
Lung	84 NX

B-cells	39 NX
Colon	46 NX
Liver	37 NX
Kidney	31 NX

Basal glandular cells	41 NX
Prostate	41 NX

Basal keratinocytes	20 NX
Skin	20 NX

Bipolar cells	26 NX
Eye	26 NX

Cardiomyocytes	6 NX
Heart muscle	6 NX

Cholangiocytes	28 NX
Liver	28 NX

Ciliated cells	108 NX
Lung	108 NX

Club cells	52 NX
Lung	52 NX

Collecting duct cells	51 NX
Kidney	51 NX

Cone photoreceptor cells	47 NX
Eye	47 NX

Cytotrophoblasts	82 NX
Placenta	82 NX

Distal tubular cells	7 NX
Kidney	7 NX

Ductal cells	51 NX
Pancreas	51 NX

Early spermatids	19 NX
Testis	19 NX

Endothelial cells	11 NX
Placenta	169 NX
Prostate	75 NX
Pancreas	43 NX
Heart muscle	15 NX
Testis	11 NX
Skin	11 NX
Eye	11 NX
Lung	9 NX
Liver	2 NX

Enterocytes	45 NX
Colon	114 NX
Rectum	32 NX
Small intestine	19 NX

Erythroid cells	47 NX
Liver	47 NX

Exocrine glandular cells	73 NX
Pancreas	73 NX

Extravillous trophoblasts	112 NX
Placenta	112 NX

Fibroblasts	55 NX
Placenta	104 NX
Prostate	60 NX
Lung	55 NX
Skin	16 NX
Heart muscle	10 NX

Glandular cells	80 NX
Prostate	80 NX

Granulocytes	41 NX
Colon	64 NX
Lung	19 NX

Hepatocytes	16 NX
Liver	16 NX

Hofbauer cells	49 NX
Placenta	49 NX

Horizontal cells	140 NX
Eye	140 NX

Intestinal endocrine cells	30 NX
Colon	37 NX
Rectum	23 NX

Ito cells	12 NX
Liver	12 NX

Kupffer cells	13 NX
Liver	13 NX

Late spermatids	10 NX
Testis	10 NX

Leydig cells	22 NX
Testis	22 NX

Macrophages	16 NX
Pancreas	30 NX
Prostate	26 NX
Skin	21 NX
Lung	16 NX
Kidney	15 NX
Testis	12 NX

Melanocytes	20 NX
Skin	20 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	154 NX
Pancreas	154 NX

Mucus-secreting cells	29 NX
Colon	103 NX
Rectum	37 NX
Small intestine	15 NX

Muller glia cells	24 NX
Eye	24 NX

Pancreatic endocrine cells	65 NX
Pancreas	65 NX

Paneth cells	21 NX
Colon	72 NX
Small intestine	21 NX
Rectum	9 NX

Peritubular cells	10 NX
Testis	10 NX

Proximal tubular cells	3 NX
Kidney	3 NX

Rod photoreceptor cells	48 NX
Eye	48 NX

Sertoli cells	26 NX
Testis	26 NX

Smooth muscle cells	29 NX
Pancreas	67 NX
Prostate	29 NX
Heart muscle	29 NX
Skin	14 NX

Spermatocytes	132 NX
Testis	132 NX

Spermatogonia	152 NX
Testis	152 NX

Suprabasal keratinocytes	78 NX
Skin	78 NX

Syncytiotrophoblasts	182 NX
Placenta	182 NX

T-cells	18 NX
Lung	33 NX
Colon	29 NX
Skin	28 NX
Kidney	19 NX
Prostate	18 NX
Liver	1 NX

Undifferentiated cells	20 NX
Colon	58 NX
Rectum	18 NX
Small intestine	12 NX

Urothelial cells	100 NX
Prostate	100 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.