Cell type atlas - HERC1 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

HERC1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	HERC1
Gene descriptionⁱ Full gene name according to HGNC.	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	6 NX
Lung	6 NX

Alveolar cells type 2	36 NX
Lung	36 NX

B-cells	27 NX
Kidney	27 NX
Colon	27 NX
Liver	15 NX

Basal glandular cells	9 NX
Prostate	9 NX

Basal keratinocytes	13 NX
Skin	13 NX

Bipolar cells	57 NX
Eye	57 NX

Cardiomyocytes	57 NX
Heart muscle	57 NX

Cholangiocytes	8 NX
Liver	8 NX

Ciliated cells	19 NX
Lung	19 NX

Club cells	21 NX
Lung	21 NX

Collecting duct cells	21 NX
Kidney	21 NX

Cone photoreceptor cells	63 NX
Eye	63 NX

Cytotrophoblasts	7 NX
Placenta	7 NX

Distal tubular cells	2 NX
Kidney	2 NX

Ductal cells	9 NX
Pancreas	9 NX

Early spermatids	19 NX
Testis	19 NX

Endothelial cells	26 NX
Heart muscle	96 NX
Liver	43 NX
Eye	35 NX
Placenta	26 NX
Lung	26 NX
Testis	26 NX
Pancreas	25 NX
Skin	24 NX
Prostate	21 NX

Enterocytes	12 NX
Colon	12 NX
Small intestine	11 NX
Rectum	10 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	12 NX
Pancreas	12 NX

Extravillous trophoblasts	9 NX
Placenta	9 NX

Fibroblasts	18 NX
Heart muscle	42 NX
Prostate	21 NX
Skin	20 NX
Lung	18 NX
Placenta	9 NX

Glandular cells	13 NX
Prostate	13 NX

Granulocytes	49 NX
Lung	60 NX
Colon	37 NX

Hepatocytes	18 NX
Liver	18 NX

Hofbauer cells	15 NX
Placenta	15 NX

Horizontal cells	81 NX
Eye	81 NX

Intestinal endocrine cells	10 NX
Colon	10 NX
Rectum	9 NX

Ito cells	52 NX
Liver	52 NX

Kupffer cells	39 NX
Liver	39 NX

Late spermatids	13 NX
Testis	13 NX

Leydig cells	26 NX
Testis	26 NX

Macrophages	23 NX
Lung	29 NX
Skin	24 NX
Testis	22 NX
Prostate	21 NX
Kidney	19 NX
Pancreas	12 NX

Melanocytes	19 NX
Skin	19 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	23 NX
Pancreas	23 NX

Mucus-secreting cells	13 NX
Rectum	15 NX
Small intestine	12 NX
Colon	8 NX

Muller glia cells	25 NX
Eye	25 NX

Pancreatic endocrine cells	11 NX
Pancreas	11 NX

Paneth cells	14 NX
Small intestine	21 NX
Rectum	14 NX
Colon	6 NX

Peritubular cells	37 NX
Testis	37 NX

Proximal tubular cells	13 NX
Kidney	13 NX

Rod photoreceptor cells	55 NX
Eye	55 NX

Sertoli cells	7 NX
Testis	7 NX

Smooth muscle cells	18 NX
Heart muscle	47 NX
Skin	22 NX
Prostate	18 NX
Pancreas	11 NX

Spermatocytes	46 NX
Testis	46 NX

Spermatogonia	29 NX
Testis	29 NX

Suprabasal keratinocytes	13 NX
Skin	13 NX

Syncytiotrophoblasts	7 NX
Placenta	7 NX

T-cells	35 NX
Colon	53 NX
Liver	39 NX
Lung	36 NX
Prostate	35 NX
Skin	33 NX
Kidney	21 NX

Undifferentiated cells	12 NX
Rectum	16 NX
Small intestine	12 NX
Colon	11 NX

Urothelial cells	9 NX
Prostate	9 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.