Cell type atlas - STX4 - The Human Protein Atlas

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STX4

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	STX4
Gene descriptionⁱ Full gene name according to HGNC.	Syntaxin 4
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	42 NX
Lung	42 NX

Alveolar cells type 2	21 NX
Lung	21 NX

B-cells	22 NX
Colon	52 NX
Kidney	27 NX
Liver	15 NX

Basal glandular cells	31 NX
Prostate	31 NX

Basal keratinocytes	58 NX
Skin	58 NX

Bipolar cells	7 NX
Eye	7 NX

Cardiomyocytes	21 NX
Heart muscle	21 NX

Cholangiocytes	46 NX
Liver	46 NX

Ciliated cells	35 NX
Lung	35 NX

Club cells	24 NX
Lung	24 NX

Collecting duct cells	21 NX
Kidney	21 NX

Cone photoreceptor cells	12 NX
Eye	12 NX

Cytotrophoblasts	27 NX
Placenta	27 NX

Distal tubular cells	25 NX
Kidney	25 NX

Ductal cells	50 NX
Pancreas	50 NX

Early spermatids	6 NX
Testis	6 NX

Endothelial cells	41 NX
Prostate	82 NX
Skin	62 NX
Pancreas	54 NX
Lung	44 NX
Eye	41 NX
Placenta	37 NX
Liver	32 NX
Testis	30 NX
Heart muscle	28 NX

Enterocytes	70 NX
Colon	71 NX
Small intestine	68 NX
Rectum	49 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	59 NX
Pancreas	59 NX

Extravillous trophoblasts	32 NX
Placenta	32 NX

Fibroblasts	50 NX
Lung	108 NX
Prostate	84 NX
Skin	65 NX
Placenta	30 NX
Heart muscle	20 NX

Glandular cells	41 NX
Prostate	41 NX

Granulocytes	60 NX
Colon	83 NX
Lung	37 NX

Hepatocytes	17 NX
Liver	17 NX

Hofbauer cells	84 NX
Placenta	84 NX

Horizontal cells	5 NX
Eye	5 NX

Intestinal endocrine cells	25 NX
Colon	31 NX
Rectum	19 NX

Ito cells	29 NX
Liver	29 NX

Kupffer cells	48 NX
Liver	48 NX

Late spermatids	11 NX
Testis	11 NX

Leydig cells	36 NX
Testis	36 NX

Macrophages	89 NX
Skin	107 NX
Prostate	100 NX
Pancreas	98 NX
Lung	97 NX
Kidney	63 NX
Testis	47 NX

Melanocytes	29 NX
Skin	29 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	62 NX
Pancreas	62 NX

Mucus-secreting cells	35 NX
Small intestine	46 NX
Rectum	36 NX
Colon	33 NX

Muller glia cells	21 NX
Eye	21 NX

Pancreatic endocrine cells	58 NX
Pancreas	58 NX

Paneth cells	47 NX
Colon	75 NX
Rectum	47 NX
Small intestine	35 NX

Peritubular cells	33 NX
Testis	33 NX

Proximal tubular cells	46 NX
Kidney	46 NX

Rod photoreceptor cells	6 NX
Eye	6 NX

Sertoli cells	39 NX
Testis	39 NX

Smooth muscle cells	44 NX
Skin	56 NX
Prostate	45 NX
Pancreas	40 NX
Heart muscle	18 NX

Spermatocytes	7 NX
Testis	7 NX

Spermatogonia	8 NX
Testis	8 NX

Suprabasal keratinocytes	57 NX
Skin	57 NX

Syncytiotrophoblasts	28 NX
Placenta	28 NX

T-cells	41 NX
Skin	59 NX
Colon	44 NX
Liver	41 NX
Kidney	39 NX
Lung	37 NX
Prostate	18 NX

Undifferentiated cells	41 NX
Colon	42 NX
Rectum	41 NX
Small intestine	38 NX

Urothelial cells	30 NX
Prostate	30 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.