Cell type atlas - RBL2 - The Human Protein Atlas

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RBL2

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	RBL2
Gene descriptionⁱ Full gene name according to HGNC.	RB transcriptional corepressor like 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Early spermatids)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Early spermatids)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	39 NX
Lung	39 NX

Alveolar cells type 2	83 NX
Lung	83 NX

B-cells	24 NX
Colon	33 NX
Liver	24 NX
Kidney	18 NX

Basal glandular cells	27 NX
Prostate	27 NX

Basal keratinocytes	21 NX
Skin	21 NX

Bipolar cells	27 NX
Eye	27 NX

Cardiomyocytes	10 NX
Heart muscle	10 NX

Cholangiocytes	41 NX
Liver	41 NX

Ciliated cells	43 NX
Lung	43 NX

Club cells	43 NX
Lung	43 NX

Collecting duct cells	26 NX
Kidney	26 NX

Cone photoreceptor cells	20 NX
Eye	20 NX

Cytotrophoblasts	5 NX
Placenta	5 NX

Distal tubular cells	15 NX
Kidney	15 NX

Ductal cells	11 NX
Pancreas	11 NX

Early spermatids	411 NX
Testis	410 NX

Endothelial cells	24 NX
Lung	53 NX
Testis	39 NX
Liver	34 NX
Eye	27 NX
Skin	25 NX
Prostate	21 NX
Heart muscle	17 NX
Placenta	16 NX
Pancreas	11 NX

Enterocytes	19 NX
Rectum	37 NX
Small intestine	25 NX
Colon	7 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	9 NX
Pancreas	9 NX

Extravillous trophoblasts	12 NX
Placenta	12 NX

Fibroblasts	23 NX
Lung	34 NX
Skin	25 NX
Heart muscle	25 NX
Placenta	18 NX
Prostate	17 NX

Glandular cells	38 NX
Prostate	38 NX

Granulocytes	53 NX
Lung	60 NX
Colon	46 NX

Hepatocytes	41 NX
Liver	41 NX

Hofbauer cells	10 NX
Placenta	10 NX

Horizontal cells	33 NX
Eye	33 NX

Intestinal endocrine cells	19 NX
Rectum	21 NX
Colon	17 NX

Ito cells	33 NX
Liver	33 NX

Kupffer cells	46 NX
Liver	46 NX

Late spermatids	129 NX
Testis	129 NX

Leydig cells	39 NX
Testis	39 NX

Macrophages	26 NX
Testis	41 NX
Lung	37 NX
Skin	25 NX
Prostate	23 NX
Kidney	22 NX
Pancreas	7 NX

Melanocytes	10 NX
Skin	10 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	23 NX
Pancreas	23 NX

Mucus-secreting cells	32 NX
Small intestine	42 NX
Rectum	35 NX
Colon	9 NX

Muller glia cells	37 NX
Eye	37 NX

Pancreatic endocrine cells	10 NX
Pancreas	10 NX

Paneth cells	11 NX
Rectum	33 NX
Small intestine	11 NX
Colon	9 NX

Peritubular cells	40 NX
Testis	40 NX

Proximal tubular cells	21 NX
Kidney	21 NX

Rod photoreceptor cells	23 NX
Eye	23 NX

Sertoli cells	39 NX
Testis	39 NX

Smooth muscle cells	25 NX
Prostate	31 NX
Skin	27 NX
Heart muscle	25 NX
Pancreas	8 NX

Spermatocytes	118 NX
Testis	118 NX

Spermatogonia	42 NX
Testis	42 NX

Suprabasal keratinocytes	24 NX
Skin	24 NX

Syncytiotrophoblasts	3 NX
Placenta	3 NX

T-cells	79 NX
Lung	101 NX
Liver	97 NX
Kidney	92 NX
Colon	79 NX
Skin	49 NX
Prostate	22 NX

Undifferentiated cells	24 NX
Rectum	28 NX
Small intestine	19 NX
Colon	6 NX

Urothelial cells	31 NX
Prostate	31 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.