Cell type atlas - GGA2 - The Human Protein Atlas

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GGA2

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	GGA2
Gene descriptionⁱ Full gene name according to HGNC.	Golgi associated, gamma adaptin ear containing, ARF binding protein 2
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Rod photoreceptor cells, monocytes)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (Daudi, U-698)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Rod photoreceptor cells, monocytes)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	45 NX
Lung	45 NX

Alveolar cells type 2	34 NX
Lung	34 NX

B-cells	59 NX
Colon	106 NX
Kidney	76 NX
Liver	37 NX

Basal glandular cells	31 NX
Prostate	31 NX

Basal keratinocytes	30 NX
Skin	30 NX

Bipolar cells	64 NX
Eye	64 NX

Cardiomyocytes	24 NX
Heart muscle	24 NX

Cholangiocytes	18 NX
Liver	18 NX

Ciliated cells	15 NX
Lung	15 NX

Club cells	21 NX
Lung	21 NX

Collecting duct cells	21 NX
Kidney	21 NX

Cone photoreceptor cells	108 NX
Eye	108 NX

Cytotrophoblasts	19 NX
Placenta	19 NX

Distal tubular cells	22 NX
Kidney	22 NX

Ductal cells	15 NX
Pancreas	15 NX

Early spermatids	20 NX
Testis	20 NX

Endothelial cells	18 NX
Heart muscle	34 NX
Lung	26 NX
Eye	25 NX
Testis	23 NX
Liver	22 NX
Placenta	16 NX
Prostate	14 NX
Skin	14 NX
Pancreas	14 NX

Enterocytes	7 NX
Small intestine	8 NX
Rectum	7 NX
Colon	4 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	16 NX
Pancreas	16 NX

Extravillous trophoblasts	32 NX
Placenta	32 NX

Fibroblasts	17 NX
Placenta	20 NX
Skin	18 NX
Heart muscle	16 NX
Prostate	14 NX
Lung	10 NX

Glandular cells	18 NX
Prostate	18 NX

Granulocytes	9 NX
Colon	9 NX
Lung	9 NX

Hepatocytes	14 NX
Liver	14 NX

Hofbauer cells	60 NX
Placenta	60 NX

Horizontal cells	6 NX
Eye	6 NX

Intestinal endocrine cells	17 NX
Rectum	31 NX
Colon	3 NX

Ito cells	14 NX
Liver	14 NX

Kupffer cells	22 NX
Liver	22 NX

Late spermatids	25 NX
Testis	25 NX

Leydig cells	23 NX
Testis	23 NX

Macrophages	24 NX
Lung	55 NX
Prostate	40 NX
Testis	25 NX
Pancreas	23 NX
Skin	20 NX
Kidney	15 NX

Melanocytes	25 NX
Skin	25 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	118 NX
Pancreas	118 NX

Mucus-secreting cells	12 NX
Small intestine	12 NX
Rectum	12 NX
Colon	9 NX

Muller glia cells	21 NX
Eye	21 NX

Pancreatic endocrine cells	16 NX
Pancreas	16 NX

Paneth cells	7 NX
Rectum	10 NX
Small intestine	7 NX
Colon	0 NX

Peritubular cells	25 NX
Testis	25 NX

Proximal tubular cells	16 NX
Kidney	16 NX

Rod photoreceptor cells	163 NX
Eye	163 NX

Sertoli cells	19 NX
Testis	19 NX

Smooth muscle cells	14 NX
Heart muscle	23 NX
Skin	18 NX
Prostate	14 NX
Pancreas	13 NX

Spermatocytes	28 NX
Testis	28 NX

Spermatogonia	66 NX
Testis	66 NX

Suprabasal keratinocytes	13 NX
Skin	13 NX

Syncytiotrophoblasts	19 NX
Placenta	19 NX

T-cells	25 NX
Colon	39 NX
Skin	33 NX
Prostate	26 NX
Kidney	25 NX
Lung	22 NX
Liver	19 NX

Undifferentiated cells	11 NX
Rectum	13 NX
Small intestine	10 NX
Colon	10 NX

Urothelial cells	16 NX
Prostate	16 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.