Cell type atlas - UBE2I - The Human Protein Atlas

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UBE2I

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	UBE2I
Gene descriptionⁱ Full gene name according to HGNC.	Ubiquitin conjugating enzyme E2 I
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Plasma proteins Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	11

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	48 NX
Lung	48 NX

Alveolar cells type 2	65 NX
Lung	65 NX

B-cells	162 NX
Colon	209 NX
Liver	159 NX
Kidney	156 NX

Basal glandular cells	150 NX
Prostate	150 NX

Basal keratinocytes	159 NX
Skin	159 NX

Bipolar cells	58 NX
Eye	58 NX

Cardiomyocytes	79 NX
Heart muscle	79 NX

Cholangiocytes	79 NX
Liver	79 NX

Ciliated cells	47 NX
Lung	47 NX

Club cells	86 NX
Lung	86 NX

Collecting duct cells	59 NX
Kidney	59 NX

Cone photoreceptor cells	47 NX
Eye	47 NX

Cytotrophoblasts	272 NX
Placenta	272 NX

Distal tubular cells	90 NX
Kidney	90 NX

Ductal cells	195 NX
Pancreas	195 NX

Early spermatids	44 NX
Testis	44 NX

Endothelial cells	107 NX
Pancreas	172 NX
Prostate	146 NX
Placenta	141 NX
Testis	114 NX
Skin	113 NX
Liver	106 NX
Eye	88 NX
Heart muscle	86 NX
Lung	61 NX

Enterocytes	70 NX
Small intestine	76 NX
Rectum	69 NX
Colon	62 NX

Erythroid cells	47 NX
Liver	47 NX

Exocrine glandular cells	129 NX
Pancreas	129 NX

Extravillous trophoblasts	244 NX
Placenta	244 NX

Fibroblasts	135 NX
Placenta	169 NX
Prostate	166 NX
Skin	133 NX
Heart muscle	83 NX
Lung	77 NX

Glandular cells	170 NX
Prostate	170 NX

Granulocytes	105 NX
Lung	128 NX
Colon	83 NX

Hepatocytes	34 NX
Liver	34 NX

Hofbauer cells	188 NX
Placenta	188 NX

Horizontal cells	45 NX
Eye	45 NX

Intestinal endocrine cells	98 NX
Colon	112 NX
Rectum	84 NX

Ito cells	79 NX
Liver	79 NX

Kupffer cells	89 NX
Liver	89 NX

Late spermatids	25 NX
Testis	25 NX

Leydig cells	120 NX
Testis	120 NX

Macrophages	129 NX
Pancreas	197 NX
Kidney	155 NX
Skin	149 NX
Testis	128 NX
Prostate	108 NX
Lung	100 NX

Melanocytes	121 NX
Skin	121 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	251 NX
Pancreas	251 NX

Mucus-secreting cells	90 NX
Rectum	93 NX
Colon	87 NX
Small intestine	76 NX

Muller glia cells	79 NX
Eye	79 NX

Pancreatic endocrine cells	176 NX
Pancreas	176 NX

Paneth cells	98 NX
Colon	104 NX
Rectum	98 NX
Small intestine	46 NX

Peritubular cells	101 NX
Testis	101 NX

Proximal tubular cells	90 NX
Kidney	90 NX

Rod photoreceptor cells	59 NX
Eye	59 NX

Sertoli cells	78 NX
Testis	78 NX

Smooth muscle cells	105 NX
Pancreas	202 NX
Prostate	105 NX
Skin	100 NX
Heart muscle	72 NX

Spermatocytes	123 NX
Testis	123 NX

Spermatogonia	163 NX
Testis	163 NX

Suprabasal keratinocytes	181 NX
Skin	181 NX

Syncytiotrophoblasts	350 NX
Placenta	350 NX

T-cells	135 NX
Skin	195 NX
Colon	163 NX
Kidney	161 NX
Liver	133 NX
Lung	115 NX
Prostate	113 NX

Undifferentiated cells	123 NX
Small intestine	143 NX
Colon	132 NX
Rectum	110 NX

Urothelial cells	223 NX
Prostate	223 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.