Cell type atlas - MAPK3 - The Human Protein Atlas

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MAPK3

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MAPK3
Gene descriptionⁱ Full gene name according to HGNC.	Mitogen-activated protein kinase 3
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Enzymes FDA approved drug targets RAS pathway related proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	8

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Enterocytes, Early spermatids)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (eosinophil, neutrophil)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Enterocytes, Early spermatids)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	21 NX
Lung	21 NX

Alveolar cells type 2	20 NX
Lung	20 NX

B-cells	9 NX
Kidney	9 NX
Colon	9 NX
Liver	6 NX

Basal glandular cells	19 NX
Prostate	19 NX

Basal keratinocytes	9 NX
Skin	9 NX

Bipolar cells	28 NX
Eye	28 NX

Cardiomyocytes	13 NX
Heart muscle	13 NX

Cholangiocytes	15 NX
Liver	15 NX

Ciliated cells	20 NX
Lung	20 NX

Club cells	8 NX
Lung	8 NX

Collecting duct cells	9 NX
Kidney	9 NX

Cone photoreceptor cells	22 NX
Eye	22 NX

Cytotrophoblasts	67 NX
Placenta	67 NX

Distal tubular cells	20 NX
Kidney	20 NX

Ductal cells	31 NX
Pancreas	31 NX

Early spermatids	255 NX
Testis	255 NX

Endothelial cells	50 NX
Placenta	81 NX
Testis	81 NX
Pancreas	79 NX
Liver	76 NX
Eye	55 NX
Prostate	50 NX
Skin	46 NX
Heart muscle	37 NX
Lung	18 NX

Enterocytes	275 NX
Colon	318 NX
Rectum	247 NX
Small intestine	184 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	55 NX
Pancreas	55 NX

Extravillous trophoblasts	107 NX
Placenta	107 NX

Fibroblasts	26 NX
Placenta	31 NX
Skin	23 NX
Prostate	23 NX
Heart muscle	19 NX
Lung	16 NX

Glandular cells	12 NX
Prostate	12 NX

Granulocytes	2 NX
Lung	5 NX
Colon	0 NX

Hepatocytes	6 NX
Liver	6 NX

Hofbauer cells	39 NX
Placenta	38 NX

Horizontal cells	8 NX
Eye	8 NX

Intestinal endocrine cells	53 NX
Rectum	68 NX
Colon	37 NX

Ito cells	53 NX
Liver	53 NX

Kupffer cells	25 NX
Liver	25 NX

Late spermatids	107 NX
Testis	107 NX

Leydig cells	30 NX
Testis	30 NX

Macrophages	19 NX
Testis	30 NX
Pancreas	28 NX
Kidney	24 NX
Prostate	20 NX
Skin	14 NX
Lung	12 NX

Melanocytes	22 NX
Skin	22 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	28 NX
Pancreas	28 NX

Mucus-secreting cells	136 NX
Colon	163 NX
Small intestine	159 NX
Rectum	104 NX

Muller glia cells	38 NX
Eye	38 NX

Pancreatic endocrine cells	77 NX
Pancreas	77 NX

Paneth cells	98 NX
Colon	265 NX
Rectum	98 NX
Small intestine	84 NX

Peritubular cells	26 NX
Testis	26 NX

Proximal tubular cells	18 NX
Kidney	18 NX

Rod photoreceptor cells	33 NX
Eye	33 NX

Sertoli cells	19 NX
Testis	19 NX

Smooth muscle cells	19 NX
Pancreas	47 NX
Prostate	22 NX
Skin	17 NX
Heart muscle	7 NX

Spermatocytes	11 NX
Testis	11 NX

Spermatogonia	18 NX
Testis	18 NX

Suprabasal keratinocytes	12 NX
Skin	12 NX

Syncytiotrophoblasts	28 NX
Placenta	28 NX

T-cells	13 NX
Kidney	21 NX
Skin	14 NX
Liver	13 NX
Colon	13 NX
Prostate	9 NX
Lung	7 NX

Undifferentiated cells	64 NX
Colon	108 NX
Rectum	64 NX
Small intestine	60 NX

Urothelial cells	18 NX
Prostate	18 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.