Cell type atlas - INTS6 - The Human Protein Atlas

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INTS6

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	INTS6
Gene descriptionⁱ Full gene name according to HGNC.	Integrator complex subunit 6
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	10

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	24 NX
Lung	24 NX

Alveolar cells type 2	44 NX
Lung	44 NX

B-cells	51 NX
Colon	100 NX
Liver	51 NX
Kidney	45 NX

Basal glandular cells	45 NX
Prostate	45 NX

Basal keratinocytes	68 NX
Skin	68 NX

Bipolar cells	61 NX
Eye	61 NX

Cardiomyocytes	72 NX
Heart muscle	72 NX

Cholangiocytes	43 NX
Liver	43 NX

Ciliated cells	12 NX
Lung	12 NX

Club cells	21 NX
Lung	21 NX

Collecting duct cells	21 NX
Kidney	21 NX

Cone photoreceptor cells	112 NX
Eye	112 NX

Cytotrophoblasts	61 NX
Placenta	61 NX

Distal tubular cells	13 NX
Kidney	13 NX

Ductal cells	20 NX
Pancreas	20 NX

Early spermatids	64 NX
Testis	64 NX

Endothelial cells	45 NX
Eye	89 NX
Prostate	82 NX
Skin	49 NX
Placenta	45 NX
Liver	43 NX
Heart muscle	40 NX
Testis	31 NX
Lung	9 NX
Pancreas	4 NX

Enterocytes	75 NX
Colon	108 NX
Rectum	70 NX
Small intestine	65 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	23 NX
Pancreas	23 NX

Extravillous trophoblasts	40 NX
Placenta	40 NX

Fibroblasts	44 NX
Prostate	76 NX
Skin	67 NX
Heart muscle	44 NX
Placenta	25 NX
Lung	19 NX

Glandular cells	58 NX
Prostate	57 NX

Granulocytes	48 NX
Colon	74 NX
Lung	23 NX

Hepatocytes	32 NX
Liver	32 NX

Hofbauer cells	31 NX
Placenta	31 NX

Horizontal cells	43 NX
Eye	43 NX

Intestinal endocrine cells	73 NX
Colon	85 NX
Rectum	61 NX

Ito cells	64 NX
Liver	64 NX

Kupffer cells	51 NX
Liver	51 NX

Late spermatids	65 NX
Testis	65 NX

Leydig cells	41 NX
Testis	41 NX

Macrophages	39 NX
Lung	58 NX
Prostate	43 NX
Skin	43 NX
Kidney	35 NX
Testis	31 NX
Pancreas	7 NX

Melanocytes	22 NX
Skin	22 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	23 NX
Pancreas	23 NX

Mucus-secreting cells	75 NX
Colon	109 NX
Small intestine	82 NX
Rectum	74 NX

Muller glia cells	61 NX
Eye	61 NX

Pancreatic endocrine cells	22 NX
Pancreas	22 NX

Paneth cells	52 NX
Colon	63 NX
Rectum	52 NX
Small intestine	46 NX

Peritubular cells	30 NX
Testis	30 NX

Proximal tubular cells	10 NX
Kidney	10 NX

Rod photoreceptor cells	77 NX
Eye	77 NX

Sertoli cells	26 NX
Testis	26 NX

Smooth muscle cells	47 NX
Prostate	79 NX
Skin	51 NX
Heart muscle	29 NX
Pancreas	17 NX

Spermatocytes	98 NX
Testis	98 NX

Spermatogonia	42 NX
Testis	42 NX

Suprabasal keratinocytes	63 NX
Skin	63 NX

Syncytiotrophoblasts	62 NX
Placenta	62 NX

T-cells	61 NX
Prostate	140 NX
Colon	85 NX
Kidney	77 NX
Liver	58 NX
Skin	42 NX
Lung	25 NX

Undifferentiated cells	65 NX
Colon	85 NX
Rectum	65 NX
Small intestine	64 NX

Urothelial cells	60 NX
Prostate	60 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.