Cell type atlas - BEX4 - The Human Protein Atlas

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BEX4

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	BEX4
Gene descriptionⁱ Full gene name according to HGNC.	Brain expressed X-linked 4
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Syncytiotrophoblasts)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (HEL, HMC-1, K-562)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Syncytiotrophoblasts)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	33 NX
Lung	33 NX

Alveolar cells type 2	30 NX
Lung	30 NX

B-cells	36 NX
Colon	66 NX
Kidney	58 NX
Liver	8 NX

Basal glandular cells	116 NX
Prostate	116 NX

Basal keratinocytes	24 NX
Skin	24 NX

Bipolar cells	177 NX
Eye	177 NX

Cardiomyocytes	68 NX
Heart muscle	68 NX

Cholangiocytes	43 NX
Liver	43 NX

Ciliated cells	36 NX
Lung	36 NX

Club cells	57 NX
Lung	57 NX

Collecting duct cells	94 NX
Kidney	94 NX

Cone photoreceptor cells	24 NX
Eye	24 NX

Cytotrophoblasts	266 NX
Placenta	266 NX

Distal tubular cells	254 NX
Kidney	254 NX

Ductal cells	53 NX
Pancreas	53 NX

Early spermatids	2 NX
Testis	2 NX

Endothelial cells	47 NX
Placenta	128 NX
Eye	83 NX
Prostate	69 NX
Testis	65 NX
Pancreas	47 NX
Liver	45 NX
Skin	34 NX
Lung	32 NX
Heart muscle	24 NX

Enterocytes	6 NX
Rectum	7 NX
Small intestine	6 NX
Colon	3 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	12 NX
Pancreas	12 NX

Extravillous trophoblasts	139 NX
Placenta	139 NX

Fibroblasts	44 NX
Prostate	92 NX
Placenta	52 NX
Heart muscle	44 NX
Skin	38 NX
Lung	36 NX

Glandular cells	99 NX
Prostate	99 NX

Granulocytes	108 NX
Colon	147 NX
Lung	70 NX

Hepatocytes	1 NX
Liver	1 NX

Hofbauer cells	82 NX
Placenta	82 NX

Horizontal cells	210 NX
Eye	210 NX

Intestinal endocrine cells	61 NX
Rectum	70 NX
Colon	51 NX

Ito cells	49 NX
Liver	49 NX

Kupffer cells	48 NX
Liver	48 NX

Late spermatids	7 NX
Testis	7 NX

Leydig cells	59 NX
Testis	59 NX

Macrophages	61 NX
Prostate	132 NX
Testis	79 NX
Pancreas	73 NX
Kidney	59 NX
Skin	55 NX
Lung	39 NX

Melanocytes	110 NX
Skin	110 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	191 NX
Pancreas	191 NX

Mucus-secreting cells	38 NX
Small intestine	48 NX
Rectum	38 NX
Colon	18 NX

Muller glia cells	161 NX
Eye	161 NX

Pancreatic endocrine cells	15 NX
Pancreas	15 NX

Paneth cells	25 NX
Rectum	37 NX
Small intestine	25 NX
Colon	3 NX

Peritubular cells	58 NX
Testis	58 NX

Proximal tubular cells	144 NX
Kidney	144 NX

Rod photoreceptor cells	68 NX
Eye	68 NX

Sertoli cells	52 NX
Testis	52 NX

Smooth muscle cells	45 NX
Prostate	76 NX
Heart muscle	49 NX
Skin	43 NX
Pancreas	33 NX

Spermatocytes	23 NX
Testis	23 NX

Spermatogonia	15 NX
Testis	15 NX

Suprabasal keratinocytes	21 NX
Skin	21 NX

Syncytiotrophoblasts	305 NX
Placenta	305 NX

T-cells	33 NX
Prostate	83 NX
Kidney	50 NX
Colon	33 NX
Liver	30 NX
Skin	28 NX
Lung	22 NX

Undifferentiated cells	28 NX
Small intestine	37 NX
Rectum	28 NX
Colon	11 NX

Urothelial cells	91 NX
Prostate	91 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.