Cell type atlas - MAGED2 - The Human Protein Atlas

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MAGED2

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MAGED2
Gene descriptionⁱ Full gene name according to HGNC.	MAGE family member D2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Disease related genes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	8

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Peritubular cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Peritubular cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	42 NX
Lung	42 NX

Alveolar cells type 2	34 NX
Lung	34 NX

B-cells	30 NX
Kidney	36 NX
Colon	24 NX
Liver	20 NX

Basal glandular cells	80 NX
Prostate	80 NX

Basal keratinocytes	38 NX
Skin	38 NX

Bipolar cells	72 NX
Eye	72 NX

Cardiomyocytes	52 NX
Heart muscle	52 NX

Cholangiocytes	54 NX
Liver	54 NX

Ciliated cells	67 NX
Lung	67 NX

Club cells	31 NX
Lung	31 NX

Collecting duct cells	73 NX
Kidney	73 NX

Cone photoreceptor cells	28 NX
Eye	28 NX

Cytotrophoblasts	185 NX
Placenta	185 NX

Distal tubular cells	209 NX
Kidney	209 NX

Ductal cells	88 NX
Pancreas	88 NX

Early spermatids	2 NX
Testis	2 NX

Endothelial cells	77 NX
Placenta	302 NX
Eye	134 NX
Pancreas	129 NX
Testis	110 NX
Heart muscle	83 NX
Liver	61 NX
Skin	54 NX
Lung	53 NX
Prostate	47 NX

Enterocytes	15 NX
Small intestine	21 NX
Rectum	12 NX
Colon	10 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	48 NX
Pancreas	48 NX

Extravillous trophoblasts	117 NX
Placenta	117 NX

Fibroblasts	94 NX
Placenta	407 NX
Heart muscle	94 NX
Skin	83 NX
Prostate	71 NX
Lung	55 NX

Glandular cells	95 NX
Prostate	95 NX

Granulocytes	100 NX
Colon	119 NX
Lung	81 NX

Hepatocytes	13 NX
Liver	13 NX

Hofbauer cells	61 NX
Placenta	61 NX

Horizontal cells	130 NX
Eye	130 NX

Intestinal endocrine cells	56 NX
Rectum	68 NX
Colon	44 NX

Ito cells	67 NX
Liver	67 NX

Kupffer cells	13 NX
Liver	13 NX

Late spermatids	9 NX
Testis	9 NX

Leydig cells	216 NX
Testis	216 NX

Macrophages	36 NX
Skin	49 NX
Prostate	48 NX
Pancreas	47 NX
Testis	32 NX
Kidney	21 NX
Lung	16 NX

Melanocytes	150 NX
Skin	150 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	65 NX
Pancreas	65 NX

Mucus-secreting cells	43 NX
Small intestine	47 NX
Colon	45 NX
Rectum	40 NX

Muller glia cells	179 NX
Eye	179 NX

Pancreatic endocrine cells	49 NX
Pancreas	49 NX

Paneth cells	32 NX
Small intestine	46 NX
Rectum	32 NX
Colon	14 NX

Peritubular cells	301 NX
Testis	301 NX

Proximal tubular cells	112 NX
Kidney	112 NX

Rod photoreceptor cells	50 NX
Eye	50 NX

Sertoli cells	155 NX
Testis	155 NX

Smooth muscle cells	151 NX
Pancreas	255 NX
Heart muscle	165 NX
Skin	127 NX
Prostate	99 NX

Spermatocytes	14 NX
Testis	14 NX

Spermatogonia	12 NX
Testis	12 NX

Suprabasal keratinocytes	31 NX
Skin	31 NX

Syncytiotrophoblasts	142 NX
Placenta	142 NX

T-cells	45 NX
Kidney	72 NX
Prostate	70 NX
Skin	67 NX
Lung	46 NX
Colon	45 NX
Liver	31 NX

Undifferentiated cells	25 NX
Small intestine	26 NX
Rectum	25 NX
Colon	18 NX

Urothelial cells	56 NX
Prostate	56 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.