Cell type atlas - DNTTIP1 - The Human Protein Atlas

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DNTTIP1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	DNTTIP1
Gene descriptionⁱ Full gene name according to HGNC.	Deoxynucleotidyltransferase terminal interacting protein 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (neutrophil)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (PC-3)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	15 NX
Lung	15 NX

Alveolar cells type 2	19 NX
Lung	19 NX

B-cells	23 NX
Kidney	40 NX
Liver	23 NX
Colon	13 NX

Basal glandular cells	37 NX
Prostate	37 NX

Basal keratinocytes	23 NX
Skin	23 NX

Bipolar cells	19 NX
Eye	19 NX

Cardiomyocytes	18 NX
Heart muscle	18 NX

Cholangiocytes	13 NX
Liver	13 NX

Ciliated cells	24 NX
Lung	24 NX

Club cells	22 NX
Lung	22 NX

Collecting duct cells	24 NX
Kidney	24 NX

Cone photoreceptor cells	4 NX
Eye	4 NX

Cytotrophoblasts	56 NX
Placenta	56 NX

Distal tubular cells	43 NX
Kidney	43 NX

Ductal cells	58 NX
Pancreas	58 NX

Early spermatids	31 NX
Testis	31 NX

Endothelial cells	21 NX
Pancreas	36 NX
Placenta	35 NX
Testis	26 NX
Prostate	23 NX
Liver	22 NX
Skin	21 NX
Eye	20 NX
Lung	9 NX
Heart muscle	6 NX

Enterocytes	33 NX
Colon	42 NX
Small intestine	28 NX
Rectum	28 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	67 NX
Pancreas	67 NX

Extravillous trophoblasts	36 NX
Placenta	36 NX

Fibroblasts	24 NX
Placenta	55 NX
Lung	24 NX
Skin	21 NX
Prostate	20 NX
Heart muscle	7 NX

Glandular cells	32 NX
Prostate	32 NX

Granulocytes	6 NX
Lung	12 NX
Colon	0 NX

Hepatocytes	17 NX
Liver	17 NX

Hofbauer cells	63 NX
Placenta	63 NX

Horizontal cells	19 NX
Eye	19 NX

Intestinal endocrine cells	21 NX
Rectum	26 NX
Colon	17 NX

Ito cells	23 NX
Liver	23 NX

Kupffer cells	27 NX
Liver	27 NX

Late spermatids	11 NX
Testis	11 NX

Leydig cells	26 NX
Testis	26 NX

Macrophages	34 NX
Pancreas	68 NX
Prostate	50 NX
Kidney	43 NX
Skin	34 NX
Testis	30 NX
Lung	16 NX

Melanocytes	15 NX
Skin	15 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	87 NX
Pancreas	87 NX

Mucus-secreting cells	70 NX
Colon	135 NX
Rectum	92 NX
Small intestine	29 NX

Muller glia cells	42 NX
Eye	42 NX

Pancreatic endocrine cells	70 NX
Pancreas	70 NX

Paneth cells	52 NX
Small intestine	53 NX
Colon	52 NX
Rectum	33 NX

Peritubular cells	26 NX
Testis	26 NX

Proximal tubular cells	33 NX
Kidney	33 NX

Rod photoreceptor cells	24 NX
Eye	24 NX

Sertoli cells	0 NX
Testis	0 NX

Smooth muscle cells	25 NX
Pancreas	48 NX
Prostate	28 NX
Skin	23 NX
Heart muscle	10 NX

Spermatocytes	78 NX
Testis	78 NX

Spermatogonia	34 NX
Testis	34 NX

Suprabasal keratinocytes	24 NX
Skin	24 NX

Syncytiotrophoblasts	48 NX
Placenta	48 NX

T-cells	18 NX
Kidney	24 NX
Prostate	22 NX
Skin	21 NX
Liver	17 NX
Colon	16 NX
Lung	4 NX

Undifferentiated cells	32 NX
Colon	43 NX
Rectum	31 NX
Small intestine	31 NX

Urothelial cells	55 NX
Prostate	55 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.