Cell type atlas - WFDC2 - The Human Protein Atlas

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WFDC2

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	WFDC2
Gene descriptionⁱ Full gene name according to HGNC.	WAP four-disulfide core domain 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Secreted
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Urothelial cells, Collecting duct cells, Basal glandular cells, Mucus-secreting cells, Club cells, Ciliated cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enriched (plasmacytoid DC)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in single
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Group enriched (A-431, CAPAN-2, EFO-21, HaCaT, RPTEC TERT1)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in some
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Extracellular locationⁱ A possible secretion of the protein was predicted based on N-terminal signal sequence (signal peptide) predictions and transmembrane region predictions, and subsequently annotated for its local or systemic secretion based on literature, function, and protein and RNA expression data. Read more	Protein predicted to be secreted

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Urothelial cells, Collecting duct cells, Basal glandular cells, Mucus-secreting cells, Club cells, Ciliated cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	158 NX
Lung	158 NX

Alveolar cells type 2	202 NX
Lung	202 NX

B-cells	3 NX
Colon	18 NX
Kidney	5 NX
Liver	1 NX

Basal glandular cells	1207 NX
Prostate	1207 NX

Basal keratinocytes	8 NX
Skin	8 NX

Bipolar cells	24 NX
Eye	24 NX

Cardiomyocytes	1 NX
Heart muscle	1 NX

Cholangiocytes	107 NX
Liver	107 NX

Ciliated cells	1080 NX
Lung	1080 NX

Club cells	1101 NX
Lung	1101 NX

Collecting duct cells	1886 NX
Kidney	1886 NX

Cone photoreceptor cells	22 NX
Eye	22 NX

Cytotrophoblasts	1 NX
Placenta	1 NX

Distal tubular cells	187 NX
Kidney	187 NX

Ductal cells	214 NX
Pancreas	214 NX

Early spermatids	1 NX
Testis	1 NX

Endothelial cells	1 NX
Prostate	86 NX
Lung	20 NX
Eye	2 NX
Testis	1 NX
Placenta	1 NX
Skin	1 NX
Heart muscle	1 NX
Pancreas	0 NX
Liver	0 NX

Enterocytes	88 NX
Rectum	228 NX
Colon	132 NX
Small intestine	2 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	118 NX
Pancreas	118 NX

Extravillous trophoblasts	1 NX
Placenta	1 NX

Fibroblasts	4 NX
Prostate	61 NX
Lung	60 NX
Placenta	13 NX
Heart muscle	5 NX
Skin	2 NX

Glandular cells	848 NX
Prostate	848 NX

Granulocytes	9 NX
Lung	19 NX
Colon	0 NX

Hepatocytes	1 NX
Liver	1 NX

Hofbauer cells	2 NX
Placenta	2 NX

Horizontal cells	0 NX
Eye	0 NX

Intestinal endocrine cells	406 NX
Rectum	517 NX
Colon	296 NX

Ito cells	3 NX
Liver	3 NX

Kupffer cells	1 NX
Liver	1 NX

Late spermatids	3 NX
Testis	3 NX

Leydig cells	33 NX
Testis	33 NX

Macrophages	6 NX
Prostate	73 NX
Lung	23 NX
Kidney	10 NX
Skin	1 NX
Pancreas	0 NX
Testis	0 NX

Melanocytes	10 NX
Skin	10 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	10 NX
Pancreas	10 NX

Mucus-secreting cells	1147 NX
Colon	1667 NX
Rectum	1286 NX
Small intestine	20 NX

Muller glia cells	15 NX
Eye	15 NX

Pancreatic endocrine cells	130 NX
Pancreas	130 NX

Paneth cells	455 NX
Rectum	584 NX
Colon	455 NX
Small intestine	102 NX

Peritubular cells	0 NX
Testis	0 NX

Proximal tubular cells	78 NX
Kidney	78 NX

Rod photoreceptor cells	4 NX
Eye	4 NX

Sertoli cells	7 NX
Testis	7 NX

Smooth muscle cells	12 NX
Prostate	140 NX
Skin	14 NX
Pancreas	12 NX
Heart muscle	1 NX

Spermatocytes	12 NX
Testis	12 NX

Spermatogonia	11 NX
Testis	11 NX

Suprabasal keratinocytes	12 NX
Skin	12 NX

Syncytiotrophoblasts	1 NX
Placenta	1 NX

T-cells	1 NX
Prostate	52 NX
Kidney	40 NX
Lung	17 NX
Colon	14 NX
Skin	1 NX
Liver	0 NX

Undifferentiated cells	278 NX
Rectum	425 NX
Colon	278 NX
Small intestine	12 NX

Urothelial cells	3036 NX
Prostate	3036 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.