Cell type atlas - HM13 - The Human Protein Atlas

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HM13

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	HM13
Gene descriptionⁱ Full gene name according to HGNC.	Histocompatibility minor 13
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Hofbauer cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Hofbauer cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	48 NX
Lung	48 NX

Alveolar cells type 2	56 NX
Lung	56 NX

B-cells	31 NX
Liver	139 NX
Colon	36 NX
Kidney	27 NX

Basal glandular cells	46 NX
Prostate	46 NX

Basal keratinocytes	30 NX
Skin	30 NX

Bipolar cells	39 NX
Eye	39 NX

Cardiomyocytes	12 NX
Heart muscle	12 NX

Cholangiocytes	59 NX
Liver	59 NX

Ciliated cells	39 NX
Lung	39 NX

Club cells	43 NX
Lung	43 NX

Collecting duct cells	51 NX
Kidney	51 NX

Cone photoreceptor cells	116 NX
Eye	116 NX

Cytotrophoblasts	131 NX
Placenta	131 NX

Distal tubular cells	12 NX
Kidney	12 NX

Ductal cells	140 NX
Pancreas	140 NX

Early spermatids	12 NX
Testis	12 NX

Endothelial cells	44 NX
Placenta	103 NX
Pancreas	86 NX
Prostate	67 NX
Liver	49 NX
Eye	44 NX
Lung	44 NX
Skin	38 NX
Testis	32 NX
Heart muscle	17 NX

Enterocytes	63 NX
Colon	110 NX
Rectum	47 NX
Small intestine	46 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	147 NX
Pancreas	147 NX

Extravillous trophoblasts	111 NX
Placenta	111 NX

Fibroblasts	87 NX
Placenta	150 NX
Prostate	104 NX
Lung	76 NX
Skin	61 NX
Heart muscle	12 NX

Glandular cells	75 NX
Prostate	75 NX

Granulocytes	41 NX
Lung	54 NX
Colon	28 NX

Hepatocytes	74 NX
Liver	74 NX

Hofbauer cells	293 NX
Placenta	293 NX

Horizontal cells	41 NX
Eye	41 NX

Intestinal endocrine cells	59 NX
Colon	78 NX
Rectum	40 NX

Ito cells	58 NX
Liver	58 NX

Kupffer cells	73 NX
Liver	73 NX

Late spermatids	11 NX
Testis	11 NX

Leydig cells	56 NX
Testis	56 NX

Macrophages	84 NX
Pancreas	271 NX
Kidney	126 NX
Prostate	93 NX
Lung	80 NX
Skin	74 NX
Testis	71 NX

Melanocytes	62 NX
Skin	62 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	39 NX
Pancreas	39 NX

Mucus-secreting cells	63 NX
Colon	226 NX
Small intestine	66 NX
Rectum	58 NX

Muller glia cells	50 NX
Eye	50 NX

Pancreatic endocrine cells	139 NX
Pancreas	139 NX

Paneth cells	43 NX
Colon	133 NX
Rectum	43 NX
Small intestine	42 NX

Peritubular cells	41 NX
Testis	41 NX

Proximal tubular cells	44 NX
Kidney	44 NX

Rod photoreceptor cells	39 NX
Eye	39 NX

Sertoli cells	32 NX
Testis	32 NX

Smooth muscle cells	39 NX
Pancreas	274 NX
Prostate	58 NX
Skin	35 NX
Heart muscle	21 NX

Spermatocytes	22 NX
Testis	22 NX

Spermatogonia	29 NX
Testis	29 NX

Suprabasal keratinocytes	31 NX
Skin	31 NX

Syncytiotrophoblasts	179 NX
Placenta	179 NX

T-cells	57 NX
Colon	69 NX
Kidney	66 NX
Lung	62 NX
Prostate	57 NX
Skin	49 NX
Liver	37 NX

Undifferentiated cells	52 NX
Colon	109 NX
Small intestine	53 NX
Rectum	46 NX

Urothelial cells	55 NX
Prostate	55 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.