Cell type atlas - CSNK2A1 - The Human Protein Atlas

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CSNK2A1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CSNK2A1
Gene descriptionⁱ Full gene name according to HGNC.	Casein kinase 2 alpha 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	30

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	60 NX
Lung	60 NX

Alveolar cells type 2	73 NX
Lung	73 NX

B-cells	45 NX
Kidney	49 NX
Liver	45 NX
Colon	25 NX

Basal glandular cells	31 NX
Prostate	31 NX

Basal keratinocytes	37 NX
Skin	37 NX

Bipolar cells	46 NX
Eye	46 NX

Cardiomyocytes	54 NX
Heart muscle	54 NX

Cholangiocytes	33 NX
Liver	33 NX

Ciliated cells	80 NX
Lung	80 NX

Club cells	85 NX
Lung	85 NX

Collecting duct cells	42 NX
Kidney	42 NX

Cone photoreceptor cells	30 NX
Eye	30 NX

Cytotrophoblasts	35 NX
Placenta	35 NX

Distal tubular cells	35 NX
Kidney	35 NX

Ductal cells	61 NX
Pancreas	61 NX

Early spermatids	104 NX
Testis	104 NX

Endothelial cells	35 NX
Pancreas	61 NX
Eye	46 NX
Testis	44 NX
Prostate	43 NX
Lung	35 NX
Heart muscle	32 NX
Placenta	31 NX
Liver	27 NX
Skin	26 NX

Enterocytes	34 NX
Rectum	48 NX
Small intestine	35 NX
Colon	25 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	44 NX
Pancreas	44 NX

Extravillous trophoblasts	47 NX
Placenta	47 NX

Fibroblasts	35 NX
Lung	70 NX
Prostate	40 NX
Heart muscle	40 NX
Placenta	36 NX
Skin	21 NX

Glandular cells	37 NX
Prostate	37 NX

Granulocytes	60 NX
Lung	93 NX
Colon	28 NX

Hepatocytes	26 NX
Liver	26 NX

Hofbauer cells	29 NX
Placenta	29 NX

Horizontal cells	57 NX
Eye	57 NX

Intestinal endocrine cells	34 NX
Colon	44 NX
Rectum	23 NX

Ito cells	22 NX
Liver	22 NX

Kupffer cells	30 NX
Liver	30 NX

Late spermatids	105 NX
Testis	105 NX

Leydig cells	38 NX
Testis	38 NX

Macrophages	35 NX
Lung	96 NX
Kidney	51 NX
Prostate	38 NX
Pancreas	33 NX
Testis	31 NX
Skin	27 NX

Melanocytes	14 NX
Skin	14 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	68 NX
Pancreas	68 NX

Mucus-secreting cells	41 NX
Rectum	46 NX
Small intestine	37 NX
Colon	28 NX

Muller glia cells	34 NX
Eye	34 NX

Pancreatic endocrine cells	54 NX
Pancreas	54 NX

Paneth cells	25 NX
Rectum	49 NX
Small intestine	25 NX
Colon	20 NX

Peritubular cells	35 NX
Testis	35 NX

Proximal tubular cells	56 NX
Kidney	56 NX

Rod photoreceptor cells	27 NX
Eye	27 NX

Sertoli cells	52 NX
Testis	52 NX

Smooth muscle cells	33 NX
Pancreas	54 NX
Heart muscle	40 NX
Skin	32 NX
Prostate	31 NX

Spermatocytes	61 NX
Testis	61 NX

Spermatogonia	54 NX
Testis	54 NX

Suprabasal keratinocytes	44 NX
Skin	44 NX

Syncytiotrophoblasts	51 NX
Placenta	51 NX

T-cells	32 NX
Lung	58 NX
Kidney	40 NX
Liver	34 NX
Colon	28 NX
Skin	22 NX
Prostate	13 NX

Undifferentiated cells	39 NX
Small intestine	40 NX
Rectum	39 NX
Colon	32 NX

Urothelial cells	45 NX
Prostate	45 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.