Cell type atlas - C20orf27 - The Human Protein Atlas

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C20orf27

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	C20orf27
Gene descriptionⁱ Full gene name according to HGNC.	Chromosome 20 open reading frame 27
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Hofbauer cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (intermediate monocyte, non-classical monocyte, myeloid DC, classical monocyte)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Hofbauer cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	0 NX
Lung	0 NX

Alveolar cells type 2	4 NX
Lung	4 NX

B-cells	25 NX
Colon	27 NX
Liver	25 NX
Kidney	22 NX

Basal glandular cells	18 NX
Prostate	18 NX

Basal keratinocytes	22 NX
Skin	22 NX

Bipolar cells	9 NX
Eye	9 NX

Cardiomyocytes	3 NX
Heart muscle	3 NX

Cholangiocytes	8 NX
Liver	8 NX

Ciliated cells	1 NX
Lung	1 NX

Club cells	2 NX
Lung	2 NX

Collecting duct cells	10 NX
Kidney	10 NX

Cone photoreceptor cells	2 NX
Eye	2 NX

Cytotrophoblasts	16 NX
Placenta	16 NX

Distal tubular cells	25 NX
Kidney	25 NX

Ductal cells	31 NX
Pancreas	31 NX

Early spermatids	8 NX
Testis	8 NX

Endothelial cells	25 NX
Eye	62 NX
Skin	34 NX
Pancreas	32 NX
Placenta	27 NX
Prostate	25 NX
Testis	17 NX
Liver	7 NX
Heart muscle	3 NX
Lung	0 NX

Enterocytes	11 NX
Small intestine	15 NX
Rectum	4 NX
Colon	3 NX

Erythroid cells	70 NX
Liver	70 NX

Exocrine glandular cells	26 NX
Pancreas	26 NX

Extravillous trophoblasts	39 NX
Placenta	39 NX

Fibroblasts	26 NX
Placenta	41 NX
Skin	24 NX
Prostate	13 NX
Lung	6 NX
Heart muscle	3 NX

Glandular cells	9 NX
Prostate	9 NX

Granulocytes	23 NX
Colon	37 NX
Lung	9 NX

Hepatocytes	15 NX
Liver	15 NX

Hofbauer cells	123 NX
Placenta	123 NX

Horizontal cells	2 NX
Eye	2 NX

Intestinal endocrine cells	15 NX
Rectum	23 NX
Colon	7 NX

Ito cells	14 NX
Liver	14 NX

Kupffer cells	95 NX
Liver	95 NX

Late spermatids	14 NX
Testis	14 NX

Leydig cells	30 NX
Testis	30 NX

Macrophages	60 NX
Prostate	114 NX
Kidney	100 NX
Testis	86 NX
Skin	56 NX
Pancreas	54 NX
Lung	21 NX

Melanocytes	35 NX
Skin	35 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	5 NX
Pancreas	5 NX

Mucus-secreting cells	10 NX
Small intestine	17 NX
Rectum	12 NX
Colon	9 NX

Muller glia cells	20 NX
Eye	20 NX

Pancreatic endocrine cells	29 NX
Pancreas	29 NX

Paneth cells	16 NX
Small intestine	21 NX
Rectum	16 NX
Colon	3 NX

Peritubular cells	23 NX
Testis	23 NX

Proximal tubular cells	27 NX
Kidney	27 NX

Rod photoreceptor cells	13 NX
Eye	13 NX

Sertoli cells	65 NX
Testis	65 NX

Smooth muscle cells	66 NX
Skin	125 NX
Prostate	77 NX
Pancreas	66 NX
Heart muscle	9 NX

Spermatocytes	19 NX
Testis	19 NX

Spermatogonia	30 NX
Testis	30 NX

Suprabasal keratinocytes	29 NX
Skin	29 NX

Syncytiotrophoblasts	6 NX
Placenta	6 NX

T-cells	16 NX
Prostate	31 NX
Colon	26 NX
Kidney	26 NX
Skin	16 NX
Liver	14 NX
Lung	7 NX

Undifferentiated cells	30 NX
Small intestine	49 NX
Rectum	24 NX
Colon	24 NX

Urothelial cells	20 NX
Prostate	20 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.