Cell type atlas - YY1 - The Human Protein Atlas

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YY1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	YY1
Gene descriptionⁱ Full gene name according to HGNC.	YY1 transcription factor
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Plasma proteins Transcription factors
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	51 NX
Lung	51 NX

Alveolar cells type 2	54 NX
Lung	54 NX

B-cells	77 NX
Colon	94 NX
Liver	77 NX
Kidney	40 NX

Basal glandular cells	90 NX
Prostate	90 NX

Basal keratinocytes	211 NX
Skin	211 NX

Bipolar cells	79 NX
Eye	79 NX

Cardiomyocytes	73 NX
Heart muscle	73 NX

Cholangiocytes	61 NX
Liver	61 NX

Ciliated cells	36 NX
Lung	36 NX

Club cells	39 NX
Lung	39 NX

Collecting duct cells	65 NX
Kidney	65 NX

Cone photoreceptor cells	77 NX
Eye	77 NX

Cytotrophoblasts	101 NX
Placenta	101 NX

Distal tubular cells	61 NX
Kidney	61 NX

Ductal cells	59 NX
Pancreas	59 NX

Early spermatids	8 NX
Testis	8 NX

Endothelial cells	94 NX
Prostate	180 NX
Skin	145 NX
Eye	121 NX
Liver	110 NX
Testis	94 NX
Placenta	86 NX
Heart muscle	71 NX
Pancreas	36 NX
Lung	35 NX

Enterocytes	86 NX
Rectum	105 NX
Colon	89 NX
Small intestine	72 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	71 NX
Pancreas	71 NX

Extravillous trophoblasts	104 NX
Placenta	104 NX

Fibroblasts	90 NX
Prostate	181 NX
Skin	144 NX
Placenta	76 NX
Heart muscle	73 NX
Lung	61 NX

Glandular cells	135 NX
Prostate	135 NX

Granulocytes	70 NX
Colon	83 NX
Lung	58 NX

Hepatocytes	101 NX
Liver	101 NX

Hofbauer cells	71 NX
Placenta	71 NX

Horizontal cells	121 NX
Eye	121 NX

Intestinal endocrine cells	106 NX
Colon	122 NX
Rectum	89 NX

Ito cells	87 NX
Liver	87 NX

Kupffer cells	95 NX
Liver	95 NX

Late spermatids	11 NX
Testis	11 NX

Leydig cells	88 NX
Testis	88 NX

Macrophages	94 NX
Skin	155 NX
Prostate	152 NX
Testis	106 NX
Kidney	96 NX
Lung	62 NX
Pancreas	54 NX

Melanocytes	73 NX
Skin	73 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	45 NX
Pancreas	45 NX

Mucus-secreting cells	80 NX
Colon	139 NX
Rectum	76 NX
Small intestine	62 NX

Muller glia cells	81 NX
Eye	81 NX

Pancreatic endocrine cells	70 NX
Pancreas	70 NX

Paneth cells	89 NX
Colon	89 NX
Rectum	89 NX
Small intestine	81 NX

Peritubular cells	95 NX
Testis	95 NX

Proximal tubular cells	72 NX
Kidney	72 NX

Rod photoreceptor cells	75 NX
Eye	75 NX

Sertoli cells	91 NX
Testis	91 NX

Smooth muscle cells	110 NX
Prostate	143 NX
Skin	131 NX
Heart muscle	97 NX
Pancreas	69 NX

Spermatocytes	79 NX
Testis	79 NX

Spermatogonia	67 NX
Testis	67 NX

Suprabasal keratinocytes	212 NX
Skin	212 NX

Syncytiotrophoblasts	147 NX
Placenta	147 NX

T-cells	82 NX
Skin	141 NX
Colon	120 NX
Prostate	96 NX
Kidney	82 NX
Liver	74 NX
Lung	46 NX

Undifferentiated cells	102 NX
Colon	129 NX
Rectum	102 NX
Small intestine	92 NX

Urothelial cells	132 NX
Prostate	132 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.