Cell type atlas - PSMB5 - The Human Protein Atlas

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PSMB5

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PSMB5
Gene descriptionⁱ Full gene name according to HGNC.	Proteasome subunit beta 5
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes FDA approved drug targets Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	72 NX
Lung	72 NX

Alveolar cells type 2	51 NX
Lung	51 NX

B-cells	58 NX
Kidney	80 NX
Liver	62 NX
Colon	36 NX

Basal glandular cells	135 NX
Prostate	135 NX

Basal keratinocytes	125 NX
Skin	125 NX

Bipolar cells	57 NX
Eye	57 NX

Cardiomyocytes	135 NX
Heart muscle	135 NX

Cholangiocytes	130 NX
Liver	130 NX

Ciliated cells	150 NX
Lung	150 NX

Club cells	81 NX
Lung	81 NX

Collecting duct cells	91 NX
Kidney	91 NX

Cone photoreceptor cells	28 NX
Eye	28 NX

Cytotrophoblasts	351 NX
Placenta	351 NX

Distal tubular cells	234 NX
Kidney	234 NX

Ductal cells	262 NX
Pancreas	262 NX

Early spermatids	57 NX
Testis	57 NX

Endothelial cells	107 NX
Pancreas	265 NX
Placenta	254 NX
Prostate	215 NX
Testis	201 NX
Skin	109 NX
Liver	97 NX
Eye	93 NX
Heart muscle	67 NX
Lung	64 NX

Enterocytes	63 NX
Small intestine	72 NX
Rectum	66 NX
Colon	46 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	201 NX
Pancreas	201 NX

Extravillous trophoblasts	384 NX
Placenta	384 NX

Fibroblasts	136 NX
Placenta	250 NX
Prostate	172 NX
Skin	119 NX
Lung	108 NX
Heart muscle	86 NX

Glandular cells	131 NX
Prostate	131 NX

Granulocytes	30 NX
Lung	33 NX
Colon	28 NX

Hepatocytes	134 NX
Liver	134 NX

Hofbauer cells	191 NX
Placenta	191 NX

Horizontal cells	67 NX
Eye	67 NX

Intestinal endocrine cells	149 NX
Colon	150 NX
Rectum	147 NX

Ito cells	91 NX
Liver	91 NX

Kupffer cells	55 NX
Liver	55 NX

Late spermatids	77 NX
Testis	77 NX

Leydig cells	110 NX
Testis	110 NX

Macrophages	71 NX
Pancreas	155 NX
Kidney	113 NX
Prostate	68 NX
Skin	68 NX
Testis	63 NX
Lung	62 NX

Melanocytes	110 NX
Skin	110 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	199 NX
Pancreas	199 NX

Mucus-secreting cells	94 NX
Colon	120 NX
Rectum	103 NX
Small intestine	70 NX

Muller glia cells	137 NX
Eye	137 NX

Pancreatic endocrine cells	244 NX
Pancreas	244 NX

Paneth cells	81 NX
Rectum	104 NX
Small intestine	81 NX
Colon	55 NX

Peritubular cells	115 NX
Testis	115 NX

Proximal tubular cells	332 NX
Kidney	332 NX

Rod photoreceptor cells	54 NX
Eye	54 NX

Sertoli cells	97 NX
Testis	97 NX

Smooth muscle cells	134 NX
Pancreas	417 NX
Prostate	166 NX
Skin	121 NX
Heart muscle	109 NX

Spermatocytes	207 NX
Testis	207 NX

Spermatogonia	77 NX
Testis	77 NX

Suprabasal keratinocytes	137 NX
Skin	137 NX

Syncytiotrophoblasts	360 NX
Placenta	360 NX

T-cells	50 NX
Skin	69 NX
Kidney	63 NX
Prostate	61 NX
Lung	49 NX
Colon	46 NX
Liver	45 NX

Undifferentiated cells	123 NX
Colon	158 NX
Small intestine	124 NX
Rectum	121 NX

Urothelial cells	163 NX
Prostate	163 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.