Cell type atlas - HIF1A - The Human Protein Atlas

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HIF1A

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	HIF1A
Gene descriptionⁱ Full gene name according to HGNC.	Hypoxia inducible factor 1 alpha subunit
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Plasma proteins Transcription factors
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (eosinophil)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (LHCN-M2)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	66 NX
Lung	66 NX

Alveolar cells type 2	115 NX
Lung	115 NX

B-cells	55 NX
Colon	108 NX
Kidney	67 NX
Liver	42 NX

Basal glandular cells	72 NX
Prostate	72 NX

Basal keratinocytes	94 NX
Skin	94 NX

Bipolar cells	49 NX
Eye	49 NX

Cardiomyocytes	37 NX
Heart muscle	37 NX

Cholangiocytes	87 NX
Liver	87 NX

Ciliated cells	34 NX
Lung	34 NX

Club cells	69 NX
Lung	69 NX

Collecting duct cells	248 NX
Kidney	248 NX

Cone photoreceptor cells	47 NX
Eye	47 NX

Cytotrophoblasts	23 NX
Placenta	23 NX

Distal tubular cells	88 NX
Kidney	88 NX

Ductal cells	227 NX
Pancreas	227 NX

Early spermatids	3 NX
Testis	3 NX

Endothelial cells	114 NX
Prostate	226 NX
Lung	222 NX
Skin	175 NX
Liver	160 NX
Placenta	150 NX
Eye	82 NX
Pancreas	82 NX
Testis	51 NX
Heart muscle	38 NX

Enterocytes	31 NX
Rectum	35 NX
Colon	35 NX
Small intestine	21 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	216 NX
Pancreas	216 NX

Extravillous trophoblasts	58 NX
Placenta	58 NX

Fibroblasts	83 NX
Lung	145 NX
Prostate	127 NX
Skin	100 NX
Placenta	64 NX
Heart muscle	33 NX

Glandular cells	55 NX
Prostate	55 NX

Granulocytes	217 NX
Lung	223 NX
Colon	211 NX

Hepatocytes	24 NX
Liver	24 NX

Hofbauer cells	123 NX
Placenta	123 NX

Horizontal cells	148 NX
Eye	148 NX

Intestinal endocrine cells	64 NX
Colon	71 NX
Rectum	56 NX

Ito cells	177 NX
Liver	177 NX

Kupffer cells	144 NX
Liver	144 NX

Late spermatids	4 NX
Testis	4 NX

Leydig cells	23 NX
Testis	23 NX

Macrophages	157 NX
Prostate	471 NX
Lung	235 NX
Pancreas	211 NX
Kidney	199 NX
Testis	115 NX
Skin	80 NX

Melanocytes	98 NX
Skin	98 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	77 NX
Pancreas	77 NX

Mucus-secreting cells	37 NX
Rectum	39 NX
Colon	36 NX
Small intestine	29 NX

Muller glia cells	141 NX
Eye	141 NX

Pancreatic endocrine cells	214 NX
Pancreas	214 NX

Paneth cells	23 NX
Rectum	29 NX
Colon	23 NX
Small intestine	7 NX

Peritubular cells	46 NX
Testis	46 NX

Proximal tubular cells	116 NX
Kidney	116 NX

Rod photoreceptor cells	52 NX
Eye	52 NX

Sertoli cells	52 NX
Testis	52 NX

Smooth muscle cells	130 NX
Pancreas	174 NX
Prostate	136 NX
Skin	107 NX
Heart muscle	81 NX

Spermatocytes	27 NX
Testis	27 NX

Spermatogonia	25 NX
Testis	25 NX

Suprabasal keratinocytes	77 NX
Skin	77 NX

Syncytiotrophoblasts	21 NX
Placenta	21 NX

T-cells	61 NX
Prostate	109 NX
Lung	92 NX
Colon	70 NX
Kidney	61 NX
Skin	61 NX
Liver	30 NX

Undifferentiated cells	35 NX
Colon	51 NX
Rectum	35 NX
Small intestine	33 NX

Urothelial cells	76 NX
Prostate	76 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.