Cell type atlas - VTI1B - The Human Protein Atlas

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VTI1B

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	VTI1B
Gene descriptionⁱ Full gene name according to HGNC.	Vesicle transport through interaction with t-SNAREs 1B
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Late spermatids)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Late spermatids)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	24 NX
Lung	24 NX

Alveolar cells type 2	34 NX
Lung	34 NX

B-cells	49 NX
Colon	54 NX
Kidney	45 NX
Liver	39 NX

Basal glandular cells	47 NX
Prostate	47 NX

Basal keratinocytes	38 NX
Skin	38 NX

Bipolar cells	22 NX
Eye	22 NX

Cardiomyocytes	26 NX
Heart muscle	26 NX

Cholangiocytes	54 NX
Liver	54 NX

Ciliated cells	48 NX
Lung	48 NX

Club cells	39 NX
Lung	39 NX

Collecting duct cells	63 NX
Kidney	63 NX

Cone photoreceptor cells	22 NX
Eye	22 NX

Cytotrophoblasts	89 NX
Placenta	89 NX

Distal tubular cells	184 NX
Kidney	184 NX

Ductal cells	93 NX
Pancreas	93 NX

Early spermatids	116 NX
Testis	116 NX

Endothelial cells	47 NX
Liver	119 NX
Placenta	78 NX
Lung	55 NX
Testis	55 NX
Prostate	47 NX
Pancreas	47 NX
Skin	42 NX
Eye	29 NX
Heart muscle	20 NX

Enterocytes	135 NX
Small intestine	143 NX
Rectum	132 NX
Colon	104 NX

Erythroid cells	117 NX
Liver	117 NX

Exocrine glandular cells	115 NX
Pancreas	115 NX

Extravillous trophoblasts	144 NX
Placenta	144 NX

Fibroblasts	54 NX
Placenta	71 NX
Skin	49 NX
Prostate	46 NX
Lung	41 NX
Heart muscle	28 NX

Glandular cells	82 NX
Prostate	82 NX

Granulocytes	62 NX
Colon	64 NX
Lung	60 NX

Hepatocytes	79 NX
Liver	79 NX

Hofbauer cells	117 NX
Placenta	117 NX

Horizontal cells	14 NX
Eye	14 NX

Intestinal endocrine cells	45 NX
Colon	54 NX
Rectum	35 NX

Ito cells	56 NX
Liver	56 NX

Kupffer cells	74 NX
Liver	74 NX

Late spermatids	380 NX
Testis	380 NX

Leydig cells	39 NX
Testis	39 NX

Macrophages	65 NX
Pancreas	129 NX
Kidney	101 NX
Lung	75 NX
Testis	68 NX
Prostate	62 NX
Skin	42 NX

Melanocytes	67 NX
Skin	67 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	137 NX
Pancreas	137 NX

Mucus-secreting cells	84 NX
Small intestine	90 NX
Colon	87 NX
Rectum	82 NX

Muller glia cells	35 NX
Eye	35 NX

Pancreatic endocrine cells	113 NX
Pancreas	113 NX

Paneth cells	109 NX
Colon	115 NX
Small intestine	109 NX
Rectum	100 NX

Peritubular cells	37 NX
Testis	37 NX

Proximal tubular cells	204 NX
Kidney	204 NX

Rod photoreceptor cells	35 NX
Eye	35 NX

Sertoli cells	19 NX
Testis	19 NX

Smooth muscle cells	41 NX
Pancreas	89 NX
Prostate	55 NX
Skin	40 NX
Heart muscle	32 NX

Spermatocytes	101 NX
Testis	101 NX

Spermatogonia	66 NX
Testis	66 NX

Suprabasal keratinocytes	46 NX
Skin	46 NX

Syncytiotrophoblasts	105 NX
Placenta	105 NX

T-cells	34 NX
Colon	68 NX
Kidney	63 NX
Skin	43 NX
Lung	43 NX
Liver	27 NX
Prostate	26 NX

Undifferentiated cells	80 NX
Colon	88 NX
Rectum	80 NX
Small intestine	71 NX

Urothelial cells	77 NX
Prostate	77 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.