Cell type atlas - CNIH1 - The Human Protein Atlas

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CNIH1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CNIH1
Gene descriptionⁱ Full gene name according to HGNC.	Cornichon family AMPA receptor auxiliary protein 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	33 NX
Lung	33 NX

Alveolar cells type 2	56 NX
Lung	56 NX

B-cells	74 NX
Colon	97 NX
Liver	74 NX
Kidney	45 NX

Basal glandular cells	73 NX
Prostate	73 NX

Basal keratinocytes	94 NX
Skin	94 NX

Bipolar cells	42 NX
Eye	42 NX

Cardiomyocytes	74 NX
Heart muscle	74 NX

Cholangiocytes	43 NX
Liver	43 NX

Ciliated cells	66 NX
Lung	66 NX

Club cells	43 NX
Lung	43 NX

Collecting duct cells	44 NX
Kidney	44 NX

Cone photoreceptor cells	20 NX
Eye	20 NX

Cytotrophoblasts	81 NX
Placenta	81 NX

Distal tubular cells	76 NX
Kidney	76 NX

Ductal cells	84 NX
Pancreas	84 NX

Early spermatids	21 NX
Testis	21 NX

Endothelial cells	62 NX
Prostate	111 NX
Pancreas	107 NX
Skin	89 NX
Placenta	71 NX
Testis	62 NX
Lung	47 NX
Liver	47 NX
Heart muscle	34 NX
Eye	34 NX

Enterocytes	86 NX
Small intestine	115 NX
Rectum	87 NX
Colon	70 NX

Erythroid cells	47 NX
Liver	47 NX

Exocrine glandular cells	54 NX
Pancreas	54 NX

Extravillous trophoblasts	107 NX
Placenta	107 NX

Fibroblasts	92 NX
Placenta	110 NX
Prostate	106 NX
Skin	90 NX
Heart muscle	72 NX
Lung	57 NX

Glandular cells	77 NX
Prostate	77 NX

Granulocytes	195 NX
Colon	248 NX
Lung	142 NX

Hepatocytes	126 NX
Liver	126 NX

Hofbauer cells	106 NX
Placenta	106 NX

Horizontal cells	64 NX
Eye	64 NX

Intestinal endocrine cells	100 NX
Rectum	105 NX
Colon	95 NX

Ito cells	65 NX
Liver	65 NX

Kupffer cells	101 NX
Liver	101 NX

Late spermatids	14 NX
Testis	14 NX

Leydig cells	56 NX
Testis	56 NX

Macrophages	73 NX
Kidney	118 NX
Prostate	102 NX
Skin	73 NX
Testis	64 NX
Lung	63 NX
Pancreas	49 NX

Melanocytes	79 NX
Skin	79 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	78 NX
Pancreas	78 NX

Mucus-secreting cells	76 NX
Small intestine	91 NX
Rectum	78 NX
Colon	73 NX

Muller glia cells	42 NX
Eye	42 NX

Pancreatic endocrine cells	63 NX
Pancreas	63 NX

Paneth cells	89 NX
Small intestine	102 NX
Rectum	89 NX
Colon	72 NX

Peritubular cells	62 NX
Testis	62 NX

Proximal tubular cells	125 NX
Kidney	125 NX

Rod photoreceptor cells	36 NX
Eye	36 NX

Sertoli cells	45 NX
Testis	45 NX

Smooth muscle cells	68 NX
Pancreas	147 NX
Prostate	103 NX
Skin	65 NX
Heart muscle	59 NX

Spermatocytes	49 NX
Testis	49 NX

Spermatogonia	78 NX
Testis	78 NX

Suprabasal keratinocytes	96 NX
Skin	96 NX

Syncytiotrophoblasts	59 NX
Placenta	59 NX

T-cells	60 NX
Prostate	148 NX
Skin	112 NX
Kidney	73 NX
Colon	70 NX
Lung	42 NX
Liver	40 NX

Undifferentiated cells	96 NX
Small intestine	139 NX
Colon	120 NX
Rectum	87 NX

Urothelial cells	72 NX
Prostate	72 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.