Cell type atlas - PSMC6 - The Human Protein Atlas

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PSMC6

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PSMC6
Gene descriptionⁱ Full gene name according to HGNC.	Proteasome 26S subunit, ATPase 6
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	66 NX
Lung	66 NX

Alveolar cells type 2	57 NX
Lung	57 NX

B-cells	70 NX
Kidney	80 NX
Colon	64 NX
Liver	52 NX

Basal glandular cells	127 NX
Prostate	127 NX

Basal keratinocytes	77 NX
Skin	77 NX

Bipolar cells	60 NX
Eye	60 NX

Cardiomyocytes	71 NX
Heart muscle	71 NX

Cholangiocytes	59 NX
Liver	59 NX

Ciliated cells	98 NX
Lung	98 NX

Club cells	96 NX
Lung	96 NX

Collecting duct cells	54 NX
Kidney	54 NX

Cone photoreceptor cells	65 NX
Eye	65 NX

Cytotrophoblasts	139 NX
Placenta	139 NX

Distal tubular cells	114 NX
Kidney	114 NX

Ductal cells	112 NX
Pancreas	112 NX

Early spermatids	20 NX
Testis	20 NX

Endothelial cells	70 NX
Pancreas	147 NX
Prostate	116 NX
Eye	80 NX
Placenta	72 NX
Lung	70 NX
Skin	62 NX
Testis	57 NX
Heart muscle	44 NX
Liver	34 NX

Enterocytes	63 NX
Rectum	63 NX
Small intestine	62 NX
Colon	60 NX

Erythroid cells	47 NX
Liver	47 NX

Exocrine glandular cells	93 NX
Pancreas	93 NX

Extravillous trophoblasts	115 NX
Placenta	115 NX

Fibroblasts	84 NX
Prostate	96 NX
Placenta	90 NX
Lung	86 NX
Skin	55 NX
Heart muscle	38 NX

Glandular cells	71 NX
Prostate	71 NX

Granulocytes	65 NX
Lung	84 NX
Colon	46 NX

Hepatocytes	74 NX
Liver	74 NX

Hofbauer cells	83 NX
Placenta	83 NX

Horizontal cells	59 NX
Eye	59 NX

Intestinal endocrine cells	68 NX
Colon	95 NX
Rectum	40 NX

Ito cells	44 NX
Liver	44 NX

Kupffer cells	78 NX
Liver	78 NX

Late spermatids	18 NX
Testis	18 NX

Leydig cells	62 NX
Testis	62 NX

Macrophages	72 NX
Pancreas	103 NX
Prostate	76 NX
Lung	74 NX
Skin	72 NX
Kidney	66 NX
Testis	52 NX

Melanocytes	76 NX
Skin	76 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	72 NX
Pancreas	72 NX

Mucus-secreting cells	51 NX
Colon	60 NX
Rectum	50 NX
Small intestine	46 NX

Muller glia cells	63 NX
Eye	63 NX

Pancreatic endocrine cells	97 NX
Pancreas	97 NX

Paneth cells	46 NX
Rectum	52 NX
Small intestine	46 NX
Colon	29 NX

Peritubular cells	62 NX
Testis	62 NX

Proximal tubular cells	109 NX
Kidney	109 NX

Rod photoreceptor cells	98 NX
Eye	98 NX

Sertoli cells	71 NX
Testis	71 NX

Smooth muscle cells	100 NX
Prostate	118 NX
Pancreas	109 NX
Skin	97 NX
Heart muscle	42 NX

Spermatocytes	40 NX
Testis	40 NX

Spermatogonia	74 NX
Testis	74 NX

Suprabasal keratinocytes	63 NX
Skin	63 NX

Syncytiotrophoblasts	199 NX
Placenta	199 NX

T-cells	70 NX
Prostate	83 NX
Kidney	77 NX
Lung	76 NX
Colon	70 NX
Skin	56 NX
Liver	49 NX

Undifferentiated cells	60 NX
Colon	85 NX
Small intestine	68 NX
Rectum	49 NX

Urothelial cells	108 NX
Prostate	108 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.