Cell type atlas - FKBP3 - The Human Protein Atlas

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FKBP3

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	FKBP3
Gene descriptionⁱ Full gene name according to HGNC.	FK506 binding protein 3
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	39 NX
Lung	39 NX

Alveolar cells type 2	37 NX
Lung	37 NX

B-cells	49 NX
Kidney	62 NX
Liver	52 NX
Colon	36 NX

Basal glandular cells	83 NX
Prostate	83 NX

Basal keratinocytes	43 NX
Skin	43 NX

Bipolar cells	69 NX
Eye	69 NX

Cardiomyocytes	178 NX
Heart muscle	178 NX

Cholangiocytes	46 NX
Liver	46 NX

Ciliated cells	78 NX
Lung	78 NX

Club cells	69 NX
Lung	69 NX

Collecting duct cells	89 NX
Kidney	89 NX

Cone photoreceptor cells	10 NX
Eye	10 NX

Cytotrophoblasts	265 NX
Placenta	265 NX

Distal tubular cells	214 NX
Kidney	214 NX

Ductal cells	116 NX
Pancreas	116 NX

Early spermatids	166 NX
Testis	166 NX

Endothelial cells	49 NX
Placenta	132 NX
Lung	79 NX
Pancreas	68 NX
Testis	61 NX
Liver	56 NX
Prostate	44 NX
Skin	42 NX
Eye	39 NX
Heart muscle	38 NX

Enterocytes	61 NX
Small intestine	79 NX
Rectum	48 NX
Colon	42 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	64 NX
Pancreas	64 NX

Extravillous trophoblasts	95 NX
Placenta	95 NX

Fibroblasts	68 NX
Placenta	122 NX
Heart muscle	96 NX
Lung	68 NX
Prostate	43 NX
Skin	42 NX

Glandular cells	75 NX
Prostate	75 NX

Granulocytes	51 NX
Lung	74 NX
Colon	28 NX

Hepatocytes	85 NX
Liver	85 NX

Hofbauer cells	114 NX
Placenta	114 NX

Horizontal cells	38 NX
Eye	38 NX

Intestinal endocrine cells	54 NX
Colon	68 NX
Rectum	40 NX

Ito cells	39 NX
Liver	39 NX

Kupffer cells	37 NX
Liver	37 NX

Late spermatids	298 NX
Testis	298 NX

Leydig cells	75 NX
Testis	75 NX

Macrophages	68 NX
Pancreas	82 NX
Testis	81 NX
Lung	78 NX
Kidney	62 NX
Prostate	52 NX
Skin	45 NX

Melanocytes	66 NX
Skin	66 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	156 NX
Pancreas	156 NX

Mucus-secreting cells	63 NX
Small intestine	72 NX
Colon	66 NX
Rectum	57 NX

Muller glia cells	57 NX
Eye	57 NX

Pancreatic endocrine cells	81 NX
Pancreas	81 NX

Paneth cells	53 NX
Rectum	56 NX
Small intestine	53 NX
Colon	37 NX

Peritubular cells	92 NX
Testis	92 NX

Proximal tubular cells	168 NX
Kidney	168 NX

Rod photoreceptor cells	45 NX
Eye	45 NX

Sertoli cells	104 NX
Testis	104 NX

Smooth muscle cells	53 NX
Pancreas	136 NX
Heart muscle	65 NX
Skin	51 NX
Prostate	48 NX

Spermatocytes	146 NX
Testis	146 NX

Spermatogonia	112 NX
Testis	112 NX

Suprabasal keratinocytes	42 NX
Skin	42 NX

Syncytiotrophoblasts	138 NX
Placenta	138 NX

T-cells	48 NX
Lung	85 NX
Kidney	68 NX
Prostate	48 NX
Liver	42 NX
Colon	32 NX
Skin	32 NX

Undifferentiated cells	83 NX
Small intestine	106 NX
Colon	82 NX
Rectum	75 NX

Urothelial cells	71 NX
Prostate	71 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.