Cell type atlas - ACO2 - The Human Protein Atlas

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ACO2

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ACO2
Gene descriptionⁱ Full gene name according to HGNC.	Aconitase 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Citric acid cycle related proteins Disease related genes Enzymes Plasma proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Proximal tubular cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Proximal tubular cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	24 NX
Lung	24 NX

Alveolar cells type 2	35 NX
Lung	35 NX

B-cells	48 NX
Liver	56 NX
Kidney	54 NX
Colon	43 NX

Basal glandular cells	42 NX
Prostate	42 NX

Basal keratinocytes	17 NX
Skin	17 NX

Bipolar cells	53 NX
Eye	53 NX

Cardiomyocytes	8 NX
Heart muscle	8 NX

Cholangiocytes	54 NX
Liver	54 NX

Ciliated cells	39 NX
Lung	39 NX

Club cells	18 NX
Lung	18 NX

Collecting duct cells	58 NX
Kidney	58 NX

Cone photoreceptor cells	77 NX
Eye	77 NX

Cytotrophoblasts	85 NX
Placenta	85 NX

Distal tubular cells	111 NX
Kidney	111 NX

Ductal cells	47 NX
Pancreas	47 NX

Early spermatids	11 NX
Testis	11 NX

Endothelial cells	21 NX
Pancreas	39 NX
Placenta	39 NX
Eye	36 NX
Lung	29 NX
Testis	23 NX
Prostate	21 NX
Skin	17 NX
Liver	14 NX
Heart muscle	6 NX

Enterocytes	194 NX
Small intestine	319 NX
Rectum	193 NX
Colon	134 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	37 NX
Pancreas	37 NX

Extravillous trophoblasts	50 NX
Placenta	50 NX

Fibroblasts	23 NX
Placenta	35 NX
Lung	25 NX
Prostate	23 NX
Skin	13 NX
Heart muscle	2 NX

Glandular cells	31 NX
Prostate	31 NX

Granulocytes	40 NX
Colon	55 NX
Lung	26 NX

Hepatocytes	50 NX
Liver	50 NX

Hofbauer cells	81 NX
Placenta	81 NX

Horizontal cells	51 NX
Eye	51 NX

Intestinal endocrine cells	51 NX
Colon	58 NX
Rectum	45 NX

Ito cells	17 NX
Liver	17 NX

Kupffer cells	28 NX
Liver	28 NX

Late spermatids	7 NX
Testis	7 NX

Leydig cells	23 NX
Testis	23 NX

Macrophages	36 NX
Pancreas	89 NX
Kidney	49 NX
Prostate	38 NX
Testis	34 NX
Lung	33 NX
Skin	23 NX

Melanocytes	34 NX
Skin	34 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	87 NX
Pancreas	87 NX

Mucus-secreting cells	93 NX
Colon	99 NX
Rectum	89 NX
Small intestine	80 NX

Muller glia cells	56 NX
Eye	56 NX

Pancreatic endocrine cells	40 NX
Pancreas	40 NX

Paneth cells	88 NX
Colon	107 NX
Small intestine	88 NX
Rectum	86 NX

Peritubular cells	26 NX
Testis	26 NX

Proximal tubular cells	245 NX
Kidney	245 NX

Rod photoreceptor cells	62 NX
Eye	62 NX

Sertoli cells	58 NX
Testis	58 NX

Smooth muscle cells	31 NX
Pancreas	50 NX
Prostate	38 NX
Skin	26 NX
Heart muscle	3 NX

Spermatocytes	24 NX
Testis	24 NX

Spermatogonia	36 NX
Testis	36 NX

Suprabasal keratinocytes	14 NX
Skin	14 NX

Syncytiotrophoblasts	162 NX
Placenta	162 NX

T-cells	35 NX
Kidney	50 NX
Colon	45 NX
Lung	35 NX
Prostate	35 NX
Liver	30 NX
Skin	20 NX

Undifferentiated cells	89 NX
Rectum	117 NX
Small intestine	83 NX
Colon	73 NX

Urothelial cells	56 NX
Prostate	56 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.