Cell type atlas - TNRC6B - The Human Protein Atlas

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TNRC6B

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TNRC6B
Gene descriptionⁱ Full gene name according to HGNC.	Trinucleotide repeat containing 6B
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Cone photoreceptor cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (neutrophil)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Cone photoreceptor cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	36 NX
Lung	36 NX

Alveolar cells type 2	40 NX
Lung	40 NX

B-cells	164 NX
Colon	176 NX
Kidney	152 NX
Liver	137 NX

Basal glandular cells	57 NX
Prostate	57 NX

Basal keratinocytes	66 NX
Skin	66 NX

Bipolar cells	231 NX
Eye	231 NX

Cardiomyocytes	134 NX
Heart muscle	134 NX

Cholangiocytes	110 NX
Liver	110 NX

Ciliated cells	63 NX
Lung	63 NX

Club cells	43 NX
Lung	43 NX

Collecting duct cells	66 NX
Kidney	66 NX

Cone photoreceptor cells	432 NX
Eye	432 NX

Cytotrophoblasts	31 NX
Placenta	31 NX

Distal tubular cells	60 NX
Kidney	60 NX

Ductal cells	45 NX
Pancreas	45 NX

Early spermatids	61 NX
Testis	61 NX

Endothelial cells	95 NX
Heart muscle	170 NX
Liver	119 NX
Skin	112 NX
Eye	100 NX
Testis	95 NX
Prostate	88 NX
Placenta	55 NX
Lung	53 NX
Pancreas	32 NX

Enterocytes	69 NX
Rectum	92 NX
Small intestine	78 NX
Colon	51 NX

Erythroid cells	140 NX
Liver	140 NX

Exocrine glandular cells	51 NX
Pancreas	51 NX

Extravillous trophoblasts	18 NX
Placenta	18 NX

Fibroblasts	70 NX
Heart muscle	172 NX
Skin	107 NX
Prostate	70 NX
Lung	52 NX
Placenta	40 NX

Glandular cells	67 NX
Prostate	67 NX

Granulocytes	65 NX
Colon	74 NX
Lung	56 NX

Hepatocytes	92 NX
Liver	92 NX

Hofbauer cells	34 NX
Placenta	34 NX

Horizontal cells	323 NX
Eye	323 NX

Intestinal endocrine cells	135 NX
Rectum	145 NX
Colon	126 NX

Ito cells	108 NX
Liver	108 NX

Kupffer cells	95 NX
Liver	95 NX

Late spermatids	61 NX
Testis	61 NX

Leydig cells	104 NX
Testis	104 NX

Macrophages	58 NX
Testis	101 NX
Skin	67 NX
Kidney	66 NX
Lung	44 NX
Prostate	38 NX
Pancreas	21 NX

Melanocytes	62 NX
Skin	62 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	56 NX
Pancreas	56 NX

Mucus-secreting cells	77 NX
Small intestine	81 NX
Rectum	80 NX
Colon	50 NX

Muller glia cells	149 NX
Eye	149 NX

Pancreatic endocrine cells	49 NX
Pancreas	49 NX

Paneth cells	75 NX
Small intestine	88 NX
Rectum	75 NX
Colon	46 NX

Peritubular cells	120 NX
Testis	120 NX

Proximal tubular cells	45 NX
Kidney	45 NX

Rod photoreceptor cells	360 NX
Eye	360 NX

Sertoli cells	52 NX
Testis	52 NX

Smooth muscle cells	78 NX
Heart muscle	152 NX
Skin	83 NX
Prostate	58 NX
Pancreas	25 NX

Spermatocytes	77 NX
Testis	77 NX

Spermatogonia	88 NX
Testis	88 NX

Suprabasal keratinocytes	72 NX
Skin	72 NX

Syncytiotrophoblasts	6 NX
Placenta	6 NX

T-cells	107 NX
Skin	142 NX
Colon	129 NX
Liver	127 NX
Kidney	107 NX
Lung	94 NX
Prostate	52 NX

Undifferentiated cells	76 NX
Rectum	89 NX
Small intestine	78 NX
Colon	46 NX

Urothelial cells	52 NX
Prostate	52 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.