Cell type atlas - MKNK2 - The Human Protein Atlas

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MKNK2

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MKNK2
Gene descriptionⁱ Full gene name according to HGNC.	MAP kinase interacting serine/threonine kinase 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	8

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (HHSteC)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	36 NX
Lung	36 NX

Alveolar cells type 2	53 NX
Lung	53 NX

B-cells	43 NX
Colon	96 NX
Liver	43 NX
Kidney	27 NX

Basal glandular cells	92 NX
Prostate	92 NX

Basal keratinocytes	73 NX
Skin	73 NX

Bipolar cells	46 NX
Eye	46 NX

Cardiomyocytes	46 NX
Heart muscle	46 NX

Cholangiocytes	31 NX
Liver	31 NX

Ciliated cells	16 NX
Lung	16 NX

Club cells	11 NX
Lung	11 NX

Collecting duct cells	35 NX
Kidney	35 NX

Cone photoreceptor cells	24 NX
Eye	24 NX

Cytotrophoblasts	21 NX
Placenta	21 NX

Distal tubular cells	8 NX
Kidney	8 NX

Ductal cells	25 NX
Pancreas	25 NX

Early spermatids	6 NX
Testis	6 NX

Endothelial cells	35 NX
Liver	92 NX
Skin	71 NX
Prostate	57 NX
Heart muscle	42 NX
Lung	35 NX
Placenta	35 NX
Testis	35 NX
Eye	35 NX
Pancreas	4 NX

Enterocytes	94 NX
Rectum	170 NX
Colon	100 NX
Small intestine	83 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	48 NX
Pancreas	48 NX

Extravillous trophoblasts	31 NX
Placenta	31 NX

Fibroblasts	32 NX
Prostate	55 NX
Skin	46 NX
Heart muscle	43 NX
Placenta	22 NX
Lung	19 NX

Glandular cells	121 NX
Prostate	121 NX

Granulocytes	29 NX
Colon	37 NX
Lung	21 NX

Hepatocytes	50 NX
Liver	50 NX

Hofbauer cells	31 NX
Placenta	31 NX

Horizontal cells	40 NX
Eye	40 NX

Intestinal endocrine cells	144 NX
Colon	160 NX
Rectum	129 NX

Ito cells	58 NX
Liver	58 NX

Kupffer cells	35 NX
Liver	35 NX

Late spermatids	10 NX
Testis	10 NX

Leydig cells	19 NX
Testis	19 NX

Macrophages	27 NX
Prostate	116 NX
Skin	81 NX
Testis	25 NX
Lung	23 NX
Kidney	22 NX
Pancreas	21 NX

Melanocytes	54 NX
Skin	54 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	20 NX
Pancreas	20 NX

Mucus-secreting cells	92 NX
Colon	112 NX
Rectum	93 NX
Small intestine	69 NX

Muller glia cells	39 NX
Eye	39 NX

Pancreatic endocrine cells	47 NX
Pancreas	47 NX

Paneth cells	69 NX
Rectum	109 NX
Colon	69 NX
Small intestine	56 NX

Peritubular cells	19 NX
Testis	19 NX

Proximal tubular cells	18 NX
Kidney	18 NX

Rod photoreceptor cells	43 NX
Eye	43 NX

Sertoli cells	19 NX
Testis	19 NX

Smooth muscle cells	34 NX
Prostate	122 NX
Skin	45 NX
Heart muscle	26 NX
Pancreas	12 NX

Spermatocytes	16 NX
Testis	16 NX

Spermatogonia	22 NX
Testis	22 NX

Suprabasal keratinocytes	102 NX
Skin	102 NX

Syncytiotrophoblasts	47 NX
Placenta	47 NX

T-cells	40 NX
Prostate	70 NX
Colon	60 NX
Skin	43 NX
Liver	34 NX
Lung	26 NX
Kidney	20 NX

Undifferentiated cells	64 NX
Rectum	76 NX
Colon	70 NX
Small intestine	48 NX

Urothelial cells	111 NX
Prostate	111 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.