Cell type atlas - NRP1 - The Human Protein Atlas

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NRP1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	NRP1
Gene descriptionⁱ Full gene name according to HGNC.	Neuropilin 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes CD markers Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane,Secreted
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	14

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Sertoli cells, Ito cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enriched (plasmacytoid DC)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in some
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (fHDF/TERT166, hTERT-RPE1, TIME, U-87 MG)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Extracellular locationⁱ A possible secretion of the protein was predicted based on N-terminal signal sequence (signal peptide) predictions and transmembrane region predictions, and subsequently annotated for its local or systemic secretion based on literature, function, and protein and RNA expression data. Read more	Protein predicted to be secreted

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Sertoli cells, Ito cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	0 NX
Lung	0 NX

Alveolar cells type 2	23 NX
Lung	23 NX

B-cells	8 NX
Kidney	27 NX
Colon	11 NX
Liver	3 NX

Basal glandular cells	10 NX
Prostate	10 NX

Basal keratinocytes	14 NX
Skin	14 NX

Bipolar cells	9 NX
Eye	9 NX

Cardiomyocytes	57 NX
Heart muscle	57 NX

Cholangiocytes	36 NX
Liver	36 NX

Ciliated cells	8 NX
Lung	8 NX

Club cells	14 NX
Lung	14 NX

Collecting duct cells	17 NX
Kidney	17 NX

Cone photoreceptor cells	4 NX
Eye	4 NX

Cytotrophoblasts	49 NX
Placenta	48 NX

Distal tubular cells	2 NX
Kidney	2 NX

Ductal cells	46 NX
Pancreas	46 NX

Early spermatids	1 NX
Testis	1 NX

Endothelial cells	84 NX
Heart muscle	397 NX
Placenta	137 NX
Pancreas	111 NX
Testis	84 NX
Prostate	79 NX
Skin	68 NX
Lung	55 NX
Eye	51 NX
Liver	38 NX

Enterocytes	1 NX
Small intestine	2 NX
Colon	1 NX
Rectum	0 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	17 NX
Pancreas	17 NX

Extravillous trophoblasts	11 NX
Placenta	11 NX

Fibroblasts	39 NX
Skin	69 NX
Heart muscle	57 NX
Lung	43 NX
Placenta	35 NX
Prostate	25 NX

Glandular cells	4 NX
Prostate	4 NX

Granulocytes	7 NX
Lung	14 NX
Colon	0 NX

Hepatocytes	11 NX
Liver	11 NX

Hofbauer cells	109 NX
Placenta	109 NX

Horizontal cells	0 NX
Eye	0 NX

Intestinal endocrine cells	4 NX
Rectum	5 NX
Colon	3 NX

Ito cells	239 NX
Liver	239 NX

Kupffer cells	53 NX
Liver	53 NX

Late spermatids	3 NX
Testis	3 NX

Leydig cells	39 NX
Testis	39 NX

Macrophages	27 NX
Pancreas	119 NX
Lung	43 NX
Skin	40 NX
Kidney	27 NX
Testis	26 NX
Prostate	22 NX

Melanocytes	12 NX
Skin	12 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	9 NX
Pancreas	9 NX

Mucus-secreting cells	0 NX
Small intestine	5 NX
Colon	1 NX
Rectum	0 NX

Muller glia cells	4 NX
Eye	4 NX

Pancreatic endocrine cells	11 NX
Pancreas	11 NX

Paneth cells	0 NX
Small intestine	0 NX
Rectum	0 NX
Colon	0 NX

Peritubular cells	20 NX
Testis	20 NX

Proximal tubular cells	29 NX
Kidney	29 NX

Rod photoreceptor cells	1 NX
Eye	1 NX

Sertoli cells	278 NX
Testis	278 NX

Smooth muscle cells	65 NX
Heart muscle	361 NX
Pancreas	65 NX
Skin	62 NX
Prostate	44 NX

Spermatocytes	0 NX
Testis	0 NX

Spermatogonia	1 NX
Testis	1 NX

Suprabasal keratinocytes	9 NX
Skin	9 NX

Syncytiotrophoblasts	56 NX
Placenta	56 NX

T-cells	3 NX
Kidney	15 NX
Skin	13 NX
Lung	9 NX
Liver	1 NX
Prostate	0 NX
Colon	0 NX

Undifferentiated cells	0 NX
Small intestine	3 NX
Colon	1 NX
Rectum	0 NX

Urothelial cells	3 NX
Prostate	3 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.