Cell type atlas - ACOT7 - The Human Protein Atlas

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ACOT7

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ACOT7
Gene descriptionⁱ Full gene name according to HGNC.	Acyl-CoA thioesterase 7
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	7

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Proximal tubular cells, granulocytes, Late spermatids)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (NK-cell, plasmacytoid DC)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Proximal tubular cells, granulocytes, Late spermatids)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	6 NX
Lung	6 NX

Alveolar cells type 2	26 NX
Lung	26 NX

B-cells	14 NX
Liver	17 NX
Kidney	13 NX
Colon	3 NX

Basal glandular cells	13 NX
Prostate	13 NX

Basal keratinocytes	28 NX
Skin	28 NX

Bipolar cells	34 NX
Eye	34 NX

Cardiomyocytes	8 NX
Heart muscle	8 NX

Cholangiocytes	13 NX
Liver	13 NX

Ciliated cells	1 NX
Lung	1 NX

Club cells	8 NX
Lung	8 NX

Collecting duct cells	9 NX
Kidney	9 NX

Cone photoreceptor cells	10 NX
Eye	10 NX

Cytotrophoblasts	15 NX
Placenta	15 NX

Distal tubular cells	13 NX
Kidney	13 NX

Ductal cells	19 NX
Pancreas	19 NX

Early spermatids	74 NX
Testis	74 NX

Endothelial cells	16 NX
Placenta	45 NX
Pancreas	39 NX
Liver	20 NX
Lung	20 NX
Skin	16 NX
Prostate	16 NX
Eye	10 NX
Heart muscle	9 NX
Testis	6 NX

Enterocytes	71 NX
Small intestine	142 NX
Colon	50 NX
Rectum	27 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	6 NX
Pancreas	6 NX

Extravillous trophoblasts	23 NX
Placenta	23 NX

Fibroblasts	14 NX
Placenta	21 NX
Skin	16 NX
Lung	7 NX
Prostate	5 NX
Heart muscle	3 NX

Glandular cells	7 NX
Prostate	7 NX

Granulocytes	137 NX
Colon	202 NX
Lung	72 NX

Hepatocytes	13 NX
Liver	13 NX

Hofbauer cells	27 NX
Placenta	27 NX

Horizontal cells	45 NX
Eye	45 NX

Intestinal endocrine cells	5 NX
Colon	7 NX
Rectum	2 NX

Ito cells	6 NX
Liver	6 NX

Kupffer cells	4 NX
Liver	4 NX

Late spermatids	119 NX
Testis	118 NX

Leydig cells	3 NX
Testis	3 NX

Macrophages	17 NX
Skin	59 NX
Lung	57 NX
Kidney	19 NX
Pancreas	12 NX
Prostate	8 NX
Testis	4 NX

Melanocytes	37 NX
Skin	37 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	25 NX
Pancreas	25 NX

Mucus-secreting cells	89 NX
Small intestine	150 NX
Colon	112 NX
Rectum	49 NX

Muller glia cells	11 NX
Eye	11 NX

Pancreatic endocrine cells	17 NX
Pancreas	17 NX

Paneth cells	29 NX
Small intestine	60 NX
Rectum	29 NX
Colon	26 NX

Peritubular cells	7 NX
Testis	7 NX

Proximal tubular cells	214 NX
Kidney	214 NX

Rod photoreceptor cells	16 NX
Eye	16 NX

Sertoli cells	0 NX
Testis	0 NX

Smooth muscle cells	6 NX
Pancreas	67 NX
Skin	9 NX
Prostate	6 NX
Heart muscle	5 NX

Spermatocytes	38 NX
Testis	38 NX

Spermatogonia	27 NX
Testis	27 NX

Suprabasal keratinocytes	26 NX
Skin	26 NX

Syncytiotrophoblasts	14 NX
Placenta	14 NX

T-cells	21 NX
Prostate	57 NX
Skin	45 NX
Kidney	36 NX
Colon	21 NX
Lung	19 NX
Liver	18 NX

Undifferentiated cells	49 NX
Small intestine	56 NX
Colon	54 NX
Rectum	22 NX

Urothelial cells	20 NX
Prostate	20 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.