Cell type atlas - HSP90AB1 - The Human Protein Atlas

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HSP90AB1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	HSP90AB1
Gene descriptionⁱ Full gene name according to HGNC.	Heat shock protein 90 alpha family class B member 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Basal glandular cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Basal glandular cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	834 NX
Lung	834 NX

Alveolar cells type 2	606 NX
Lung	606 NX

B-cells	539 NX
Colon	548 NX
Kidney	530 NX
Liver	508 NX

Basal glandular cells	3438 NX
Prostate	3438 NX

Basal keratinocytes	941 NX
Skin	941 NX

Bipolar cells	289 NX
Eye	289 NX

Cardiomyocytes	1218 NX
Heart muscle	1218 NX

Cholangiocytes	456 NX
Liver	456 NX

Ciliated cells	1494 NX
Lung	1494 NX

Club cells	1075 NX
Lung	1075 NX

Collecting duct cells	347 NX
Kidney	347 NX

Cone photoreceptor cells	214 NX
Eye	214 NX

Cytotrophoblasts	960 NX
Placenta	960 NX

Distal tubular cells	618 NX
Kidney	618 NX

Ductal cells	836 NX
Pancreas	836 NX

Early spermatids	146 NX
Testis	146 NX

Endothelial cells	761 NX
Prostate	2798 NX
Skin	938 NX
Pancreas	885 NX
Lung	761 NX
Placenta	717 NX
Heart muscle	709 NX
Eye	675 NX
Testis	597 NX
Liver	510 NX

Enterocytes	375 NX
Colon	759 NX
Small intestine	296 NX
Rectum	179 NX

Erythroid cells	164 NX
Liver	164 NX

Exocrine glandular cells	597 NX
Pancreas	597 NX

Extravillous trophoblasts	897 NX
Placenta	897 NX

Fibroblasts	931 NX
Prostate	3523 NX
Lung	1756 NX
Skin	965 NX
Heart muscle	939 NX
Placenta	624 NX

Glandular cells	1320 NX
Prostate	1320 NX

Granulocytes	968 NX
Lung	1118 NX
Colon	817 NX

Hepatocytes	308 NX
Liver	308 NX

Hofbauer cells	712 NX
Placenta	712 NX

Horizontal cells	321 NX
Eye	321 NX

Intestinal endocrine cells	544 NX
Colon	744 NX
Rectum	344 NX

Ito cells	276 NX
Liver	276 NX

Kupffer cells	257 NX
Liver	257 NX

Late spermatids	157 NX
Testis	157 NX

Leydig cells	635 NX
Testis	635 NX

Macrophages	728 NX
Prostate	2780 NX
Skin	987 NX
Lung	728 NX
Testis	663 NX
Pancreas	435 NX
Kidney	401 NX

Melanocytes	699 NX
Skin	699 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	739 NX
Pancreas	739 NX

Mucus-secreting cells	375 NX
Colon	866 NX
Rectum	354 NX
Small intestine	292 NX

Muller glia cells	297 NX
Eye	297 NX

Pancreatic endocrine cells	721 NX
Pancreas	721 NX

Paneth cells	313 NX
Colon	818 NX
Rectum	313 NX
Small intestine	218 NX

Peritubular cells	575 NX
Testis	575 NX

Proximal tubular cells	561 NX
Kidney	561 NX

Rod photoreceptor cells	224 NX
Eye	224 NX

Sertoli cells	343 NX
Testis	343 NX

Smooth muscle cells	894 NX
Prostate	2868 NX
Skin	1018 NX
Heart muscle	894 NX
Pancreas	772 NX

Spermatocytes	198 NX
Testis	198 NX

Spermatogonia	741 NX
Testis	741 NX

Suprabasal keratinocytes	807 NX
Skin	807 NX

Syncytiotrophoblasts	939 NX
Placenta	939 NX

T-cells	460 NX
Prostate	7383 NX
Skin	888 NX
Lung	604 NX
Colon	601 NX
Kidney	460 NX
Liver	171 NX

Undifferentiated cells	568 NX
Colon	791 NX
Small intestine	568 NX
Rectum	410 NX

Urothelial cells	2341 NX
Prostate	2341 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.