Cell type atlas - SRPK1 - The Human Protein Atlas

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SRPK1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SRPK1
Gene descriptionⁱ Full gene name according to HGNC.	SRSF protein kinase 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Late spermatids, Early spermatids)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Late spermatids, Early spermatids)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	9 NX
Lung	9 NX

Alveolar cells type 2	26 NX
Lung	26 NX

B-cells	24 NX
Liver	49 NX
Colon	21 NX
Kidney	18 NX

Basal glandular cells	65 NX
Prostate	65 NX

Basal keratinocytes	38 NX
Skin	38 NX

Bipolar cells	34 NX
Eye	34 NX

Cardiomyocytes	22 NX
Heart muscle	22 NX

Cholangiocytes	13 NX
Liver	13 NX

Ciliated cells	32 NX
Lung	32 NX

Club cells	39 NX
Lung	39 NX

Collecting duct cells	21 NX
Kidney	21 NX

Cone photoreceptor cells	35 NX
Eye	35 NX

Cytotrophoblasts	43 NX
Placenta	43 NX

Distal tubular cells	25 NX
Kidney	25 NX

Ductal cells	51 NX
Pancreas	51 NX

Early spermatids	312 NX
Testis	312 NX

Endothelial cells	24 NX
Prostate	62 NX
Skin	32 NX
Testis	28 NX
Eye	24 NX
Placenta	21 NX
Liver	20 NX
Lung	20 NX
Heart muscle	18 NX
Pancreas	18 NX

Enterocytes	39 NX
Small intestine	41 NX
Colon	37 NX
Rectum	37 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	59 NX
Pancreas	59 NX

Extravillous trophoblasts	43 NX
Placenta	43 NX

Fibroblasts	21 NX
Prostate	55 NX
Placenta	26 NX
Lung	26 NX
Skin	16 NX
Heart muscle	14 NX

Glandular cells	69 NX
Prostate	69 NX

Granulocytes	7 NX
Lung	14 NX
Colon	0 NX

Hepatocytes	40 NX
Liver	40 NX

Hofbauer cells	19 NX
Placenta	19 NX

Horizontal cells	10 NX
Eye	10 NX

Intestinal endocrine cells	44 NX
Rectum	52 NX
Colon	37 NX

Ito cells	11 NX
Liver	11 NX

Kupffer cells	17 NX
Liver	17 NX

Late spermatids	402 NX
Testis	402 NX

Leydig cells	20 NX
Testis	20 NX

Macrophages	17 NX
Kidney	22 NX
Pancreas	21 NX
Testis	17 NX
Prostate	17 NX
Lung	16 NX
Skin	15 NX

Melanocytes	15 NX
Skin	15 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	36 NX
Pancreas	36 NX

Mucus-secreting cells	45 NX
Colon	49 NX
Rectum	45 NX
Small intestine	37 NX

Muller glia cells	13 NX
Eye	13 NX

Pancreatic endocrine cells	79 NX
Pancreas	79 NX

Paneth cells	42 NX
Rectum	63 NX
Small intestine	42 NX
Colon	26 NX

Peritubular cells	23 NX
Testis	23 NX

Proximal tubular cells	44 NX
Kidney	44 NX

Rod photoreceptor cells	84 NX
Eye	84 NX

Sertoli cells	7 NX
Testis	7 NX

Smooth muscle cells	23 NX
Pancreas	37 NX
Prostate	31 NX
Skin	20 NX
Heart muscle	18 NX

Spermatocytes	155 NX
Testis	155 NX

Spermatogonia	91 NX
Testis	91 NX

Suprabasal keratinocytes	37 NX
Skin	37 NX

Syncytiotrophoblasts	33 NX
Placenta	33 NX

T-cells	35 NX
Colon	45 NX
Skin	40 NX
Lung	37 NX
Prostate	35 NX
Kidney	33 NX
Liver	25 NX

Undifferentiated cells	87 NX
Small intestine	90 NX
Colon	87 NX
Rectum	68 NX

Urothelial cells	133 NX
Prostate	133 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.