Cell type atlas - NANS - The Human Protein Atlas

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NANS

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	NANS
Gene descriptionⁱ Full gene name according to HGNC.	N-acetylneuraminate synthase
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	27 NX
Lung	27 NX

Alveolar cells type 2	52 NX
Lung	52 NX

B-cells	47 NX
Liver	97 NX
Colon	58 NX
Kidney	36 NX

Basal glandular cells	108 NX
Prostate	108 NX

Basal keratinocytes	62 NX
Skin	62 NX

Bipolar cells	8 NX
Eye	8 NX

Cardiomyocytes	22 NX
Heart muscle	22 NX

Cholangiocytes	54 NX
Liver	54 NX

Ciliated cells	151 NX
Lung	151 NX

Club cells	77 NX
Lung	77 NX

Collecting duct cells	21 NX
Kidney	21 NX

Cone photoreceptor cells	18 NX
Eye	18 NX

Cytotrophoblasts	74 NX
Placenta	74 NX

Distal tubular cells	60 NX
Kidney	60 NX

Ductal cells	42 NX
Pancreas	42 NX

Early spermatids	35 NX
Testis	35 NX

Endothelial cells	57 NX
Prostate	171 NX
Skin	81 NX
Placenta	65 NX
Testis	58 NX
Pancreas	57 NX
Lung	41 NX
Eye	38 NX
Liver	27 NX
Heart muscle	25 NX

Enterocytes	177 NX
Colon	265 NX
Rectum	161 NX
Small intestine	56 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	89 NX
Pancreas	89 NX

Extravillous trophoblasts	121 NX
Placenta	121 NX

Fibroblasts	62 NX
Prostate	93 NX
Placenta	66 NX
Skin	62 NX
Lung	43 NX
Heart muscle	24 NX

Glandular cells	167 NX
Prostate	167 NX

Granulocytes	44 NX
Colon	64 NX
Lung	23 NX

Hepatocytes	29 NX
Liver	29 NX

Hofbauer cells	140 NX
Placenta	140 NX

Horizontal cells	10 NX
Eye	10 NX

Intestinal endocrine cells	62 NX
Rectum	77 NX
Colon	48 NX

Ito cells	25 NX
Liver	25 NX

Kupffer cells	53 NX
Liver	53 NX

Late spermatids	54 NX
Testis	54 NX

Leydig cells	30 NX
Testis	30 NX

Macrophages	94 NX
Prostate	175 NX
Pancreas	131 NX
Lung	102 NX
Kidney	90 NX
Skin	88 NX
Testis	74 NX

Melanocytes	123 NX
Skin	123 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	59 NX
Pancreas	59 NX

Mucus-secreting cells	196 NX
Colon	556 NX
Rectum	211 NX
Small intestine	141 NX

Muller glia cells	13 NX
Eye	13 NX

Pancreatic endocrine cells	63 NX
Pancreas	63 NX

Paneth cells	190 NX
Colon	216 NX
Rectum	190 NX
Small intestine	81 NX

Peritubular cells	25 NX
Testis	25 NX

Proximal tubular cells	48 NX
Kidney	48 NX

Rod photoreceptor cells	7 NX
Eye	7 NX

Sertoli cells	13 NX
Testis	13 NX

Smooth muscle cells	96 NX
Pancreas	121 NX
Prostate	104 NX
Skin	67 NX
Heart muscle	17 NX

Spermatocytes	7 NX
Testis	7 NX

Spermatogonia	17 NX
Testis	17 NX

Suprabasal keratinocytes	54 NX
Skin	54 NX

Syncytiotrophoblasts	126 NX
Placenta	126 NX

T-cells	28 NX
Skin	113 NX
Prostate	92 NX
Colon	72 NX
Lung	39 NX
Kidney	26 NX
Liver	20 NX

Undifferentiated cells	245 NX
Colon	336 NX
Rectum	245 NX
Small intestine	107 NX

Urothelial cells	196 NX
Prostate	196 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.