Cell type atlas - DHPS - The Human Protein Atlas

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DHPS

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	DHPS
Gene descriptionⁱ Full gene name according to HGNC.	Deoxyhypusine synthase
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	9

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	39 NX
Lung	39 NX

Alveolar cells type 2	21 NX
Lung	21 NX

B-cells	45 NX
Kidney	54 NX
Colon	48 NX
Liver	40 NX

Basal glandular cells	68 NX
Prostate	68 NX

Basal keratinocytes	49 NX
Skin	49 NX

Bipolar cells	78 NX
Eye	78 NX

Cardiomyocytes	8 NX
Heart muscle	8 NX

Cholangiocytes	23 NX
Liver	23 NX

Ciliated cells	35 NX
Lung	35 NX

Club cells	9 NX
Lung	9 NX

Collecting duct cells	31 NX
Kidney	31 NX

Cone photoreceptor cells	43 NX
Eye	43 NX

Cytotrophoblasts	43 NX
Placenta	43 NX

Distal tubular cells	73 NX
Kidney	73 NX

Ductal cells	49 NX
Pancreas	49 NX

Early spermatids	16 NX
Testis	16 NX

Endothelial cells	36 NX
Prostate	46 NX
Skin	43 NX
Eye	41 NX
Testis	40 NX
Placenta	36 NX
Pancreas	22 NX
Liver	22 NX
Lung	15 NX
Heart muscle	8 NX

Enterocytes	36 NX
Small intestine	67 NX
Rectum	37 NX
Colon	19 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	32 NX
Pancreas	32 NX

Extravillous trophoblasts	44 NX
Placenta	44 NX

Fibroblasts	37 NX
Prostate	44 NX
Placenta	38 NX
Skin	36 NX
Lung	34 NX
Heart muscle	17 NX

Glandular cells	53 NX
Prostate	53 NX

Granulocytes	23 NX
Lung	28 NX
Colon	18 NX

Hepatocytes	29 NX
Liver	29 NX

Hofbauer cells	38 NX
Placenta	38 NX

Horizontal cells	40 NX
Eye	40 NX

Intestinal endocrine cells	40 NX
Colon	44 NX
Rectum	35 NX

Ito cells	18 NX
Liver	18 NX

Kupffer cells	36 NX
Liver	36 NX

Late spermatids	22 NX
Testis	22 NX

Leydig cells	42 NX
Testis	42 NX

Macrophages	38 NX
Kidney	56 NX
Pancreas	54 NX
Testis	43 NX
Skin	38 NX
Prostate	33 NX
Lung	24 NX

Melanocytes	47 NX
Skin	47 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	71 NX
Pancreas	71 NX

Mucus-secreting cells	55 NX
Rectum	57 NX
Small intestine	55 NX
Colon	53 NX

Muller glia cells	115 NX
Eye	115 NX

Pancreatic endocrine cells	46 NX
Pancreas	46 NX

Paneth cells	63 NX
Rectum	70 NX
Colon	63 NX
Small intestine	56 NX

Peritubular cells	33 NX
Testis	33 NX

Proximal tubular cells	76 NX
Kidney	76 NX

Rod photoreceptor cells	93 NX
Eye	93 NX

Sertoli cells	45 NX
Testis	45 NX

Smooth muscle cells	56 NX
Pancreas	59 NX
Prostate	56 NX
Skin	55 NX
Heart muscle	8 NX

Spermatocytes	30 NX
Testis	30 NX

Spermatogonia	70 NX
Testis	70 NX

Suprabasal keratinocytes	45 NX
Skin	45 NX

Syncytiotrophoblasts	60 NX
Placenta	60 NX

T-cells	50 NX
Prostate	70 NX
Kidney	68 NX
Liver	51 NX
Colon	50 NX
Skin	45 NX
Lung	35 NX

Undifferentiated cells	52 NX
Small intestine	54 NX
Rectum	52 NX
Colon	45 NX

Urothelial cells	60 NX
Prostate	60 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.