Cell type atlas - COMT - The Human Protein Atlas

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COMT

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	COMT
Gene descriptionⁱ Full gene name according to HGNC.	Catechol-O-methyltransferase
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes FDA approved drug targets Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	8

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Cytotrophoblasts, Syncytiotrophoblasts)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (MCF7)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Cytotrophoblasts, Syncytiotrophoblasts)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	116 NX
Lung	116 NX

Alveolar cells type 2	65 NX
Lung	65 NX

B-cells	46 NX
Kidney	49 NX
Liver	48 NX
Colon	34 NX

Basal glandular cells	190 NX
Prostate	190 NX

Basal keratinocytes	91 NX
Skin	91 NX

Bipolar cells	68 NX
Eye	68 NX

Cardiomyocytes	30 NX
Heart muscle	30 NX

Cholangiocytes	110 NX
Liver	110 NX

Ciliated cells	88 NX
Lung	88 NX

Club cells	85 NX
Lung	85 NX

Collecting duct cells	145 NX
Kidney	145 NX

Cone photoreceptor cells	10 NX
Eye	10 NX

Cytotrophoblasts	780 NX
Placenta	780 NX

Distal tubular cells	272 NX
Kidney	272 NX

Ductal cells	173 NX
Pancreas	173 NX

Early spermatids	4 NX
Testis	4 NX

Endothelial cells	69 NX
Placenta	161 NX
Testis	93 NX
Eye	86 NX
Skin	84 NX
Pancreas	82 NX
Prostate	61 NX
Liver	49 NX
Lung	44 NX
Heart muscle	32 NX

Enterocytes	99 NX
Small intestine	139 NX
Colon	59 NX
Rectum	29 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	167 NX
Pancreas	167 NX

Extravillous trophoblasts	75 NX
Placenta	75 NX

Fibroblasts	99 NX
Placenta	194 NX
Skin	97 NX
Prostate	84 NX
Heart muscle	56 NX
Lung	29 NX

Glandular cells	123 NX
Prostate	123 NX

Granulocytes	70 NX
Colon	83 NX
Lung	58 NX

Hepatocytes	232 NX
Liver	232 NX

Hofbauer cells	281 NX
Placenta	281 NX

Horizontal cells	24 NX
Eye	24 NX

Intestinal endocrine cells	81 NX
Colon	85 NX
Rectum	77 NX

Ito cells	75 NX
Liver	75 NX

Kupffer cells	149 NX
Liver	149 NX

Late spermatids	7 NX
Testis	7 NX

Leydig cells	124 NX
Testis	124 NX

Macrophages	142 NX
Pancreas	262 NX
Testis	166 NX
Kidney	142 NX
Lung	127 NX
Prostate	119 NX
Skin	117 NX

Melanocytes	228 NX
Skin	228 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	154 NX
Pancreas	154 NX

Mucus-secreting cells	89 NX
Small intestine	102 NX
Colon	84 NX
Rectum	78 NX

Muller glia cells	152 NX
Eye	152 NX

Pancreatic endocrine cells	163 NX
Pancreas	163 NX

Paneth cells	110 NX
Small intestine	130 NX
Rectum	110 NX
Colon	58 NX

Peritubular cells	169 NX
Testis	169 NX

Proximal tubular cells	61 NX
Kidney	61 NX

Rod photoreceptor cells	35 NX
Eye	34 NX

Sertoli cells	136 NX
Testis	136 NX

Smooth muscle cells	92 NX
Pancreas	212 NX
Prostate	92 NX
Skin	86 NX
Heart muscle	58 NX

Spermatocytes	4 NX
Testis	4 NX

Spermatogonia	5 NX
Testis	5 NX

Suprabasal keratinocytes	108 NX
Skin	108 NX

Syncytiotrophoblasts	542 NX
Placenta	542 NX

T-cells	37 NX
Liver	57 NX
Kidney	47 NX
Skin	37 NX
Lung	35 NX
Prostate	31 NX
Colon	28 NX

Undifferentiated cells	110 NX
Small intestine	135 NX
Colon	108 NX
Rectum	101 NX

Urothelial cells	181 NX
Prostate	181 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.