Cell type atlas - DPYSL2 - The Human Protein Atlas

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DPYSL2

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	DPYSL2
Gene descriptionⁱ Full gene name according to HGNC.	Dihydropyrimidinase like 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Ito cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (intermediate monocyte, myeloid DC, classical monocyte, non-classical monocyte, plasmacytoid DC)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (ASC diff, Karpas-707)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Ito cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	122 NX
Lung	122 NX

Alveolar cells type 2	68 NX
Lung	68 NX

B-cells	17 NX
Liver	37 NX
Colon	16 NX
Kidney	0 NX

Basal glandular cells	1 NX
Prostate	1 NX

Basal keratinocytes	36 NX
Skin	36 NX

Bipolar cells	105 NX
Eye	105 NX

Cardiomyocytes	87 NX
Heart muscle	87 NX

Cholangiocytes	104 NX
Liver	104 NX

Ciliated cells	17 NX
Lung	17 NX

Club cells	32 NX
Lung	32 NX

Collecting duct cells	21 NX
Kidney	21 NX

Cone photoreceptor cells	30 NX
Eye	30 NX

Cytotrophoblasts	13 NX
Placenta	13 NX

Distal tubular cells	3 NX
Kidney	3 NX

Ductal cells	17 NX
Pancreas	17 NX

Early spermatids	3 NX
Testis	3 NX

Endothelial cells	135 NX
Liver	313 NX
Heart muscle	225 NX
Skin	141 NX
Eye	140 NX
Testis	135 NX
Lung	88 NX
Placenta	72 NX
Pancreas	61 NX
Prostate	56 NX

Enterocytes	3 NX
Small intestine	4 NX
Rectum	4 NX
Colon	1 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	2 NX
Pancreas	2 NX

Extravillous trophoblasts	9 NX
Placenta	9 NX

Fibroblasts	60 NX
Heart muscle	316 NX
Skin	190 NX
Lung	60 NX
Placenta	38 NX
Prostate	29 NX

Glandular cells	1 NX
Prostate	1 NX

Granulocytes	20 NX
Lung	30 NX
Colon	9 NX

Hepatocytes	13 NX
Liver	13 NX

Hofbauer cells	46 NX
Placenta	46 NX

Horizontal cells	134 NX
Eye	134 NX

Intestinal endocrine cells	58 NX
Rectum	73 NX
Colon	44 NX

Ito cells	240 NX
Liver	240 NX

Kupffer cells	207 NX
Liver	207 NX

Late spermatids	6 NX
Testis	6 NX

Leydig cells	101 NX
Testis	101 NX

Macrophages	92 NX
Skin	161 NX
Testis	139 NX
Kidney	97 NX
Lung	79 NX
Prostate	46 NX
Pancreas	26 NX

Melanocytes	115 NX
Skin	115 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	102 NX
Pancreas	102 NX

Mucus-secreting cells	74 NX
Small intestine	138 NX
Rectum	66 NX
Colon	47 NX

Muller glia cells	141 NX
Eye	141 NX

Pancreatic endocrine cells	10 NX
Pancreas	10 NX

Paneth cells	4 NX
Small intestine	11 NX
Rectum	4 NX
Colon	3 NX

Peritubular cells	84 NX
Testis	84 NX

Proximal tubular cells	17 NX
Kidney	17 NX

Rod photoreceptor cells	37 NX
Eye	37 NX

Sertoli cells	136 NX
Testis	136 NX

Smooth muscle cells	61 NX
Heart muscle	174 NX
Skin	109 NX
Prostate	40 NX
Pancreas	22 NX

Spermatocytes	3 NX
Testis	3 NX

Spermatogonia	9 NX
Testis	9 NX

Suprabasal keratinocytes	30 NX
Skin	30 NX

Syncytiotrophoblasts	4 NX
Placenta	4 NX

T-cells	9 NX
Skin	27 NX
Lung	26 NX
Liver	11 NX
Colon	9 NX
Kidney	8 NX
Prostate	0 NX

Undifferentiated cells	7 NX
Small intestine	24 NX
Colon	7 NX
Rectum	2 NX

Urothelial cells	1 NX
Prostate	1 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.